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List of works by Claudio Isella

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits

scientific article published on 04 October 2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

scientific article published on 3 October 2017

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis.

scientific article published on 2 April 2009

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

scientific article

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

scientific article published on 21 March 2022

A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

scientific article published on 24 January 2020

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Corrigendum: Stromal contribution to the colorectal cancer transcriptome.

scientific article published in September 2016

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

scientific article

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

scientific article

FOXA1 and AR in invasive breast cancer: new findings on their co-expression and impact on prognosis in ER-positive patients.

scientific article published on 3 July 2018

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

article

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis

scientific article published on 24 April 2018

High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer.

scientific article

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

scientific article published on January 2015

Improved Outcome Prediction for Appendiceal Pseudomyxoma Peritonei by Integration of Cancer Cell and Stromal Transcriptional Profiles

scientific article published on 08 June 2020

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

scientific article published on 30 August 2018

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power

scientific article published on 20 September 2018

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers

scientific article

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

scientific article published in June 2013

MaREA: Metabolic feature extraction, enrichment and visualization of RNAseq data

scholarly article published 16 January 2018

Machine learning for RNA sequencing-based intrinsic subtyping of breast cancer

scientific article published on 21 August 2020

MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer.

scientific article published on 16 December 2011

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

scientific article

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor

scientific article

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

scientific article published on 13 August 2018

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

scientific article published on 02 August 2019

Patient-derived xenografts (PDXs) as model systems for human cancer

scientific article published on 18 February 2020

Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights

scientific article published on 10 June 2020

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.

scientific article published on June 2013

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

scientific article published on 7 February 2018

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells

scientific article published on 20 August 2019

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

scientific article published on 22 March 2018

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

scientific article published on 31 May 2017

Stromal contribution to the colorectal cancer transcriptome.

scientific article

TNF-α promotes invasive growth through the MET signaling pathway.

scientific article published on 26 September 2014

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

scientific article published on 22 February 2022

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

scientific article

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

scientific article

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

scientific article published on 30 April 2015

The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells

scientific article

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

scientific article published on 26 February 2018

Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

scientific article published on 14 February 2012

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

scientific article

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