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List of works by Bruno Cassinat

A new variant t(6;15;17)(q25;q22;q21) in acute promyelocytic leukemia: fluorescence in situ hybridization confirmation.

scientific article published on May 2005

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

scientific article published on 12 February 2019

Arsenic trioxide-based therapy of relapsed acute promyelocytic leukemia: registry results from the European LeukemiaNet

scientific article published on 28 January 2015

Assessing Bone Marrow Activity in Patients with Myelofibrosis: Results of a Pilot Study of 18F-FLT PET.

scientific article published on 30 March 2017

Association of a single-nucleotide polymorphism in the SH2B3 gene with JAK2V617F-positive myeloproliferative neoplasms

scientific article published on 01 January 2014

Auer rods and differentiation in acute promyelocytic leukemia

Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer

scientific article

Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management ⬇️

scientific article published on October 29, 2001

Chemotherapy for post-myelofibrosis acute myeloid leukemia: eradication of the leukemic clone but not the MPN clone

scientific article published on 11 August 2016

Classification of myeloproliferative disorders in the JAK2 era: is there a role for red cell mass?

scientific article published on 23 August 2007

Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations.

scientific article

Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma

scientific article published on 05 February 2007

Clonal Hematopoiesis and Atherosclerosis

scientific article published on 5 October 2017

Clonal evolution in UKE-1 cell line leading to an increase in JAK2 copy number.

scientific article

Co-expression and secretion of C3, the third component of complement and a C3-cleaving cysteine proteinase in a highly metastatic human melanoma cell line ⬇️

scientific article published on July 1, 1997

Coexistence of a myeloproliferative disorder and secondary polycythemia in the same patient

scientific article published on 31 March 2012

Combined treatment with arsenic trioxide and all-trans-retinoic acid in patients with relapsed acute promyelocytic leukemia

scientific article published in June 2003

Comprehensive clinical-molecular transplant scoring system for myelofibrosis undergoing stem cell transplantation

scientific article published on 13 February 2019

Constitutive elevation of serum alpha-fetoprotein in Fanconi anemia

scientific article published on 01 August 2000

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

scientific article published in April 2005

Development of a real-time PCR assay for quantitative detection of Encephalitozoon intestinalis DNA

scientific article

Diagnosis of Fanconi anemia in patients with bone marrow failure

scientific article published on 10 March 2009

Does increasing the JAK2V617F assay sensitivity allow to identify more patients with MPN?

scientific article published on 4 May 2012

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.

scientific article

Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features

scientific article published on 13 August 2018

Enhanced calreticulin expression in red cells of polycythemia vera patients harboring the JAK2V617F mutation.

scientific article published on 6 April 2017

Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways.

scientific article

Essential thrombocythemias without V617F JAK2 mutation are clonal hematopoietic stem cell disorders

scientific article published on 01 June 2006

Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM090

scientific article published on 17 July 2013

Evaluation of total PSA assay on vitros ECi and correlation with Kryptor-PSA assay

scientific article published on 01 January 2001

Exome analysis of treatment-related AML after APL suggests secondary evolution

scientific article published on 22 November 2018

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.

scientific article

Farnesyltransferase inhibitor tipifarnib (R115777) preferentially inhibits in vitro autonomous erythropoiesis of polycythemia vera patient cells.

scientific article published on 4 January 2005

Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response.

scientific article

From Noonan syndrome to juvenile myelomonocytic leukemia

scientific article published in June 2008

From guidelines to hospital practice: reducing inappropriate ordering of thyroid hormone and antibody tests

scientific article published on 01 June 2000

Genetic analysis of therapy-related myeloid neoplasms occurring after intensive treatment for acute promyelocytic leukemia

scientific article published on 18 April 2018

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia

scientific article published on 19 October 2010

Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia.

scientific article published on 12 June 2010

HLA-G turns off erythropoietin receptor signaling through JAK2 and JAK2 V617F dephosphorylation: clinical relevance in polycythemia vera.

scientific article published on 6 December 2007

High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a

scientific article

Identification of JAK2 mutations in canine primary polycythemia.

scientific article

Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

scientific article published in October 2003

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera.

scientific article published on 29 March 2018

In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia.

scientific article published on 4 July 2013

Inhibitory activity of human immunodeficiency virus aspartyl protease inhibitors against Encephalitozoon intestinalis evaluated by cell culture-quantitative PCR assay

scientific article

Interferon alfa therapy in CALR-mutated essential thrombocythemia.

scientific article

Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone

scientific article

Interlaboratory development and validation of a HRM method applied to the detection of JAK2 exon 12 mutations in polycythemia vera patients

scientific article

Intermethod discordance for alpha-fetoprotein measurements in Fanconi anemia

scientific article published on 01 August 2001

International external quality assurance of JAK2 V617F quantification

scientific article published on 08 December 2018

Is the thrombopoietin assay useful for differential diagnosis of thrombocytopenia? Analysis of a cohort of 160 patients with thrombocytopenia and defined platelet life span.

scientific article

JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway

scientific article

Juvenile myelomonocytic leukaemia and Noonan syndrome.

scientific article published on 5 August 2014

Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.

scientific article published on 12 October 2015

Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent.

scientific article published on 25 June 2015

Live and let (MPN cells) die! ⬇️

scientific article published on October 11, 2012

Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes

scientific article published on 12 November 2012

Long-term follow-up of European APL 2000 trial, evaluating the role of cytarabine combined with ATRA and Daunorubicin in the treatment of nonelderly APL patients

scientific article

Low incidence of CALR gene mutations in patients with cerebral venous thrombosis without overt chronic myeloproliferative neoplasm

scientific article published on 29 July 2015

Lu/BCAM-mediated cell adhesion as biological marker of JAK2V617F activity in erythrocytes of polycythemia vera patients.

scientific article

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

scientific article published on 01 March 2020

Management and treatment results in patients with acute promyelocytic leukaemia (APL) not enrolled in clinical trials

scientific article

Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients.

scientific article published on 22 May 2008

Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register.

scientific article published on 12 February 2004

Neurological disorders in essential thrombocythemia ⬇️

scientific article published on September 20, 2011

New chimeric RNAs in acute myeloid leukemia

scientific article published on 2 August 2017

New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation.

scientific article

Next-generation sequencing for JAK2 mutation testing: advantages and pitfalls

scientific article published on 26 September 2018

Outcome of acute promyelocytic leukemia (APL) in children and adolescents: an analysis in two consecutive trials of the European APL Group.

scientific article published on 2 April 2012

PML-RARalpha ligand-binding domain deletion mutations associated with reduced disease control and outcome after first relapse of APL

scientific article published on 29 October 2009

Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera

article

Pep34, a synthetic peptide whose sequence corresponds to the intracytoplasmic domain of the Epstein-Barr virus receptor (CR2, CD21), regulates human B lymphocyte proliferation triggered through CR2.

scientific article published in November 1995

Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation

scientific article published in November 2003

Pitfalls in CALR exon 9 mutation detection: A single-center experience in 571 positive patients

scientific article published on 02 July 2020

Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group

article

Quantification of JAK2V617F mutation by next-generation sequencing technology.

scientific article published on 13 May 2013

Quantification of the Mutant CALR Allelic Burden by Digital PCR: Application to Minimal Residual Disease Evaluation after Bone Marrow Transplantation.

scientific article published on 18 November 2015

Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR

scientific article published on 01 February 2000

Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations

scientific article published on 01 March 2020

Regulation of the transcriptional activity of nuclear receptors by the MEK/ERK1/2 pathway

scientific article published on 18 August 2012

Relevance of serum biomarkers associated with melanoma during follow-up of anti-CTLA-4 immunotherapy.

scientific article published on 8 October 2016

Retrospective study of allogeneic haematopoietic stem-cell transplantation for myelofibrosis.

scientific article published in November 2010

Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction

scientific article published on 12 July 2006

Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo

scientific article published on 04 October 2018

Screening for G-CSF receptor mutations in patients with secondary myeloid or lymphoid transformation of severe congenital neutropenia. A report from the French neutropenia register

scientific article published on 01 September 2004

Selective testing for calreticulin gene mutations in patients with splanchnic vein thrombosis: A prospective cohort study

scientific article published on 5 May 2017

Serum carcinoembryonic antigen, cancer antigen 125, cancer antigen 15-3, squamous cell carcinoma, and tumor-associated trypsin inhibitor concentrations during healthy pregnancy

scientific article published on 01 September 1998

Single-cell analysis reveals selection of TP53-mutated clones after MDM2 inhibition

scientific article published on 01 May 2022

Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ−/− mice

scientific article published on 13 June 2012

TET2 gene sequencing may be helpful for myeloproliferative neoplasm diagnosis

scientific article published on 16 January 2014

The JAK2 46/1 haplotype in splanchnic vein thrombosis.

scientific article

The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow

scientific article published on 13 April 2006

The V617F JAK 2 mutation is not a frequent event in patients with cerebral venous thrombosis without overt chronic myeloproliferative disorder

scientific article published on 01 June 2008

The V617F JAK2 mutation and the increase in platelet CD36 in essential thrombocythemia are unrelated events

scientific article published on 15 June 2007

The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases

scientific article published on 04 February 2008

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders

scientific article published on 9 May 2017

Tracking the extramedullary PML-RARα-positive cell reservoirs in a preclinical model: Biomarker of long-term drug efficacy ⬇️

scientific article published on August 11, 2012

Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia

scientific article published on 21 October 2008

Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia.

scientific article published in April 2002

Unexplained thrombocytosis: association of Baltimore polymorphism with germline MPL nonsense mutation.

scientific article

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

scientific article

When can real-time quantitative RT-PCR effectively define molecular relapse in acute promyelocytic leukemia patients? (Results of the French Belgian Swiss APL Group).

scientific article

Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins

scientific article published on 8 June 2015

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