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List of works by William Ka-Kei Wu

A Bayesian method for synthesizing multiple diagnostic outcomes of COVID-19 tests

scientific article published on 15 September 2021

A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain

scientific article published on 28 February 2019

A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C.

scientific article published on 3 August 2017

A Zoom-Focus algorithm (ZFA) to locate the optimal testing region for rare variant association tests.

scientific article published on 11 March 2017

A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension.

scientific article published in December 2017

A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy.

scientific article published on 11 July 2013

A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study

scientific article published on 07 September 2020

Animal models of gastrointestinal inflammation and cancer

scientific article published on 11 May 2014

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in clinical practice.

scientific article

Association between daily life experience and psychological well-being in people living with nonpsychotic mental disorders: Protocol for a systematic review and meta-analysis.

scientific article published in January 2018

Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

scientific article published on 14 April 2019

Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery

scientific article published on 01 May 2019

Autophagy in intracellular bacterial infection

scientific article published on 10 September 2019

Autophagy in sepsis: Degradation into exhaustion?

scientific article published on 12 May 2016

Autophagy inhibition enhances PD-L1 expression in gastric cancer

scientific article published on 29 March 2019

Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer

scientific article published on 20 August 2019

CCAT1: a pivotal oncogenic long non-coding RNA in human cancers

scientific article published on May 2016

Cancer antigen-125 and outcomes in acute heart failure: a systematic review and meta-analysis

scientific article published on 26 October 2018

Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis

scientific article published on 7 January 2018

Cancer genomics: From benchtop to bedside

scientific article published on 06 March 2019

Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer.

scientific article published on May 2013

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis

scientific article published on 10 February 2020

Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice.

scientific article

Cathelicidin stimulates colonic mucus synthesis by up-regulating MUC1 and MUC2 expression through a mitogen-activated protein kinase pathway.

scientific article published on May 2008

Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis

scientific article published on 28 July 2016

Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders

scientific article published on 02 August 2010

Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial.

scientific article

Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).

scientific article published on 22 May 2014

Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head.

scientific article published on 4 December 2017

Clostridium difficile toxin B induces autophagic cell death in colonocytes.

scientific article published on 31 January 2018

Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells ⬇️

scientific article published on July 3, 2012

Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumourigenesis.

scientific article published on 22 April 2016

Common Deregulation of Seven Biological Processes by MicroRNAs in Gastrointestinal Cancers

scientific article published on 19 February 2018

Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma

scientific article published on 18 June 2008

Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking.

scientific article published in October 2004

Correction: A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C.

scientific article published on 2 March 2018

Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

scientific article published on 25 June 2015

Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms.

scientific article published on 08 April 2010

Deep anesthesia: too much of a good thing?

scientific article published on 31 March 2017

Derepression of c-Fos caused by microRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma.

scientific article

Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong

scientific article published on 08 April 2021

Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish

article

Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs

scientific article published on 01 February 2004

Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells.

scientific article published on 24 December 2010

Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer.

scientific article published on 31 August 2015

Dihydrotanshinone induces p53-independent but ROS-dependent apoptosis in colon cancer cells.

scientific article

Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient: A Case Report

scientific article

Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer.

scientific article published on 31 July 2017

Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.

scientific article published on 6 January 2005

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

scientific article published on 29 July 2019

Editorial: current advances in peptides for cancer diagnosis and therapy

scientific article published on 01 January 2014

Effects of Cigarette Smoke and its Active Components on Ulcer Formation and Healing in the Gastrointestinal Mucosa ⬇️

scientific article published on January 1, 2012

Effects of adrenaline in human colon adenocarcinoma HT-29 cells

scientific article published on 30 April 2011

Effects of cigarette smoking and restraint stress on human colon tumor growth in mice.

scientific article published on 17 September 2009

Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

scientific article published on 28 July 2017

Emerging roles of MicroRNAs in osteonecrosis of the femoral head.

scientific article published on 12 November 2017

Emerging roles of long non-coding RNAs in neuropathic pain

scientific article published on 25 October 2018

Emerging roles of non-coding RNAs in scoliosis

scientific article published on 12 December 2019

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

scientific article published on 24 November 2018

Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

scientific article published on 18 October 2017

Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.

scientific article

Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer

scientific article published on 02 July 2019

FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

scientific article published on 15 September 2020

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells.

scientific article

Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

scientific article published in February 2018

Focus on gastrointestinal and liver cancers

scientific article published on 03 October 2013

Frailty and Clinical Outcomes in Advanced Heart Failure Patients Undergoing Left Ventricular Assist Device Implantation: A Systematic Review and Meta-analysis.

scientific article published on 9 November 2017

Frailty and Mortality Outcomes After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

scientific article published on 24 October 2017

Functional evaluation and cancer risk assessment of BRCA2 unclassified variants

article by William Ka-Kei Wu et al published 1 January 2005 in Cancer Research

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

scientific article

Gene-methylation epistatic analyses via the W-test identifies enriched signals of neuronal genes in patients undergoing lipid-control treatment

article

Genome-wide association and sequencing studies on colorectal cancer.

scientific article published on 02 October 2013

Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features

scientific article published on 12 February 2018

Genomics and metagenomics of colorectal cancer

scientific article published on 01 December 2019

Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning

scientific article published on 04 May 2021

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HULC: an oncogenic long non-coding RNA in human cancer

scientific article

Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development

scientific article published on 31 January 2017

Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells

scientific article published on 13 August 2020

Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer.

scientific article published on 24 October 2012

Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

scientific article published on 6 May 2015

Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study

scientific article published on 22 November 2013

Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression.

scientific article published on 4 March 2011

Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice.

scientific article published in December 2007

Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts

scientific article published in October 2016

Lentiviral expression of anti-microRNAs targeting miR-27a inhibits proliferation and invasiveness of U87 glioma cells ⬇️

scientific article published on May 15, 2012

Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells.

scientific article published on 16 January 2014

Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells

scientific article

Local infiltration with cocktail analgesics during 2 level lumbar spinal fusion surgery: Study protocol of a randomized controlled trial

scientific article published on 01 May 2019

Long non-coding RNAs in melanoma

scientific article published on 26 March 2018

Long non-coding RNAs in rheumatoid arthritis

scientific article published on 7 November 2017

Long non-coding RNAs in the spinal cord injury: Novel spotlight

scientific article published on 29 May 2019

Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation

scientific article published on 21 April 2017

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway

scientific article published on 18 July 2017

Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling

scientific article published on 14 February 2019

Meta-analysis of T-wave indices for risk stratification in myocardial infarction.

scientific article

MicroRNA dysregulation in rhabdomyosarcoma: a new player enters the game.

scientific article published on 23 July 2015

MicroRNA expression and its clinical implications in Ewing's sarcoma

scientific article published on 22 December 2014

MicroRNA in intervertebral disc degeneration.

scientific article

MicroRNA-10b Induces Vascular Muscle Cell Proliferation Through Akt Pathway by Targeting TIP30.

scientific article

MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervertebral disc degeneration

scientific article

MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1.

scientific article published on 25 October 2016

MicroRNAs predict and modulate responses to chemotherapy in colorectal cancer.

scientific article published on 22 July 2015

Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells

scientific article

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

scientific article published on 11 April 2018

NOVA1 acts as an oncogene in melanoma via regulating FOXO3a expression.

scientific article published on 2 March 2018

Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers

scientific article published on 10 April 2017

Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway ⬇️

scientific article published on October 20, 2003

Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2.

scientific article

Oncogenes expand during evolution to withstand somatic amplification

scientific article published on 01 November 2018

Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification

scientific article published on 12 January 2017

Optimizing depth of sedation for colonoscopy

scientific article

PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy.

scientific article

Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review

scientific article published on 09 December 2016

Potential and use of bacterial small RNAs to combat drug resistance: a systematic review.

scientific article published on 15 December 2017

Predictive Value of T - T Indices for Adverse Outcomes in Acquired QT Prolongation: A Meta-Analysis

scientific article published on 03 September 2018

Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery

scientific article published on 01 January 2020

Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats

scientific article published on 07 March 2007

Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats.

scientific article

Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling.

scientific article

Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis

scientific article published on 01 July 2012

RNA interference targeting raptor inhibits proliferation of gastric cancer cells.

scientific article published on 21 March 2011

Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of toxins

scientific article published on 11 January 2019

Reply

Role of microRNAs in primary central nervous system lymphomas

scientific article published on 16 March 2016

Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity

scientific article published on 27 March 2015

Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer

scientific article published on 16 July 2019

Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells.

scientific article published on 14 December 2010

Spinal microglia-neuron interactions in chronic pain

scientific article published on 23 June 2020

Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis.

scientific article

Stratified polygenic risk prediction model with application to CAGI bipolar disorder sequencing data.

scientific article

T-Wave Indices and Atherosclerosis

scientific article published on 17 September 2018

TIP30: A Novel Tumor-Suppressor Gene

scientific article

TUG1: a pivotal oncogenic long non-coding RNA of human cancers

scientific article published on 23 June 2016

Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain.

scientific article published on 9 November 2017

Targeting Proteasomal Protein Degradation in Cancer–Letter ⬇️

scientific article published on January 13, 2012

The Intersection between Oral Microbiota, Host Gene Methylation and Patient Outcomes in Head and Neck Squamous Cell Carcinoma

scientific article published on 18 November 2020

The Janus face of cathelicidin in tumorigenesis.

scientific article published on January 2014

The Role of Connexins in Gastrointestinal Diseases

scientific article published on 11 January 2019

The Tpeak - Tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: A systematic review and meta-analysis.

scientific article

The autophagic paradox in cancer therapy ⬇️

scientific article published on July 18, 2011

The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells.

scientific article

The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

scientific article published on 25 May 2004

The pharmacological actions of nicotine on the gastrointestinal tract.

scientific article

The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux.

scientific article

The role of microRNAs in intrahepatic cholangiocarcinoma

scientific article

The roles of microRNAs in Wilms' tumors

scientific article

Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: A systematic review and meta-analysis.

scientific article published on 12 September 2017

Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14‐3‐3 epsilon ⬇️

scientific article published on February 7, 2012

Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

scientific article published on 24 June 2016

Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer.

scientific article published on 21 May 2015

Warning criteria for intraoperative neurophysiologic monitoring

scientific article published on 15 July 2017

Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer

scientific article published on June 2014

microRNA deregulation in keloids: an opportunity for clinical intervention?

scientific article

wtest: an integrated R package for genetic epistasis testing

scientific article published on 24 December 2019

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