List of works by Alfredo Martínez

A new family of angiogenic factors.

scientific article

A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability

scientific article published on June 2004

Adenosine A1 receptor: A neuroprotective target in light induced retinal degeneration.

scientific article published on 18 June 2018

Adrenomedullin (AM) and adrenomedullin binding protein (AM-BP) in the bovine mammary gland and milk: Effects of stage of lactation and experimental intramammary E. coli infection.

scientific article

Adrenomedullin Contributes to Age-Related Memory Loss in Mice and Is Elevated in Aging Human Brains.

scientific article published on 15 November 2017

Adrenomedullin and tumour microenvironment.

scientific article

Adrenomedullin as a growth and cell fate regulatory factor for adult neural stem cells.

scientific article published on 24 September 2012

Adrenomedullin binding protein in the plasma of multiple species: characterization by radioligand blotting

scientific article published in October 1999

Adrenomedullin binds with high affinity, elevates cyclic AMP, and stimulates c-fos mRNA in C6 glioma cells.

scientific article published in January 1997

Adrenomedullin expression and function in the rat carotid body.

scientific article published on January 2003

Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk.

scientific article published in December 1997

Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat.

scientific article published on 26 March 2008

Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat.

scientific article

Adrenomedullin in Nonmammalian Vertebrate Pancreas: An Immunocytochemical Study

scientific article published in September 1999

Adrenomedullin in mammalian and human skin glands including the mammary gland.

scientific article

Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis

scientific article

Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz).

scientific article published on 4 November 2007

Adrenomedullin regulates club cell recovery following lung epithelial injury.

scientific article published on 14 December 2015

Adrenomedullin regulates intestinal physiology and pathophysiology.

scientific article published on July 2016

Adrenomedullin, a Novel Target for Neurodegenerative Diseases

scientific article published on 29 March 2018

Adrenomedullin-like immunoreactivity in the nervous system of the starfish Marthasterias glacialis

scientific article published on 16 January 1996

Adrenomedullin: a new and promising target for drug discovery

scientific article published in April 2006

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

scientific article

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

scientific article published on 25 January 2011

Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

scientific article published in August 2001

An Immunocytochemical Study of the Respiratory System of Podarcis hispanica (Reptilia)

scientific article published in December 1994

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

scientific article

Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors

scientific article published on March 1999

Bioactive bilayered dressing for compromised epidermal tissue regeneration with sequential activity of complementary agents.

scientific article

Biology of adrenomedullin

scientific article published on 15 March 2002

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

scientific article published in 2021

CCL5 Levels Predict Stroke Volume Growth in Acute Ischemic Stroke and Significantly Diminish in Hemorrhagic Stroke Patients

scientific article published in 2022

Cancer and diabetes: two pathological conditions in which adrenomedullin may be involved.

scientific article

Cancer protection elicited by a single nucleotide polymorphism close to the adrenomedullin gene

scientific article published on 28 February 2013

Characterization of adrenomedullin in birds.

scientific article published on 29 March 2005

Characterization of adrenomedullin in non-human primates

scientific article

Choanocyte-like cells in the digestive system of the starfishMarthasterias glacialis (Echinodermata)

scientific article published in May 1991

Cold Shock Proteins Are Expressed in the Retina Following Exposure to Low Temperatures.

scientific article

Colocalization of immunoreactivities to serotonin, calcitonin and CGRP in endocrine pulmonary cells of the iberian lizard Podarcis hispanica (Reptilia).

scientific article

Colocalization of numerous immunoreactivities in endocrine cells of the chicken proventriculus at hatching

scientific article published in 2000

Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners

scientific article

Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.

scientific article published in February 2004

Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene.

scientific article

Detection of adrenomedullin, a hypotensive peptide, in amniotic fluid and fetal membranes

scientific article published in October 1996

Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells

scientific article published on 11 March 2004

Development of the diffuse endocrine system in the chicken proventriculus

scientific article published in January 1993

Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer.

scientific article

Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development

scientific article published on March 2003

Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates

scientific article

Distribution and expression pattern of the nitrergic system in the cerebellum of the sheep

scientific article

Distribution of adrenomedullin-like immunoreactivity in the central nervous system of the frog

scientific article published in March 2001

Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy.

scientific article

Distribution of immunoreactivity for the adrenomedullin binding protein, complement factor H, in the rat brain

scientific journal article

Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxia.

scientific article published in January 2003

Doxycycline's effect on ocular angiogenesis: an in vivo analysis.

scientific article

Effect of adrenomedullin and proadrenomedullin N-terminal 20 peptide on sugar transport in the rat intestine

scientific article published in July 2005

Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: Protective role of nitric oxide inhibitors

scientific article published on 6 September 2006

Endocrine cells and nerves in the pyloric ceca and the intestine of Oncorhynchus mykiss (Teleostei): An immunocytochemical study

scientific article published in June 1992

Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action.

scientific article published in January 1997

Expression of adrenomedullin in normal human lung and in pulmonary tumors

scientific article published on 01 September 1995

Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.

scientific article published on September 2004

Expression of differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) in adult mouse tissues

scientific article published on June 2002

Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma

scientific article published on 17 April 2013

Expression pattern for adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types

scientific article published in July 1998

Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo

scientific article published on 7 March 2005

Glu-tubulin is a marker for Schwann cells and can distinguish between schwannomas and neurofibromas.

scientific article

High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease

scientific article published on 25 January 2010

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

scientific article

Hypothermia Prevents Gliosis and Angiogenesis Development in an Experimental Model of Ischemic Proliferative Retinopathy

scientific article published on 23 April 2013

Hypothermia Prevents Retinal Damage Generated by Optic Nerve Trauma in the Rat.

scientific article published on 31 July 2017

Hypothermia prevents nitric oxide system changes in retina induced by severe perinatal asphyxia

scientific article published on 17 February 2011

Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

scientific article

Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.

scientific article

Identification of Adrenomedullin in Avian Type II Pneumocytes: Increased Expression after Exposure to Air Pollutants

scientific article published in June 2005

Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily.

scientific article

Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments

scientific article

Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma

scientific article (publication date: April 2002)

Immunocytochemical and ultrastructural characterization of endocrine cells in chicken proventriculus

scientific article published in 1991

In silico identification and in vivo characterization of small molecule therapeutic hypothermia mimetics.

scientific article published on 31 October 2017

In situ detection of unexpected patterns of mutant p53 gene expression in non-small cell lung cancers

scientific article published in May 2001

Increased Levels of Brain Adrenomedullin in the Neuropathology of Alzheimer's Disease

scientific article published on 2 September 2017

Inhibition of vasopressin V1b receptor translation by upstream open reading frames in the 5'-untranslated region

scientific article published on April 2007

Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition

scientific article

Interleukin-1beta and tumor necrosis factor-alpha mediation of endotoxin action on growth hormone.

scientific article

Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.

scientific article

Involvement of astrocytes in transmissible spongiform encephalopathies: a confocal microscopy study

scientific article published on 22 July 2012

Is adrenomedullin a causal agent in some cases of type 2 diabetes?

scientific article published in December 1999

Lack of Adrenomedullin Aggravates Acute TNBS-Induced Colitis Symptoms in Mice, Especially in Females

scientific article published on 19 December 2017

Lack of Adrenomedullin Results in Microbiota Changes and Aggravates Azoxymethane and Dextran Sulfate Sodium-Induced Colitis in Mice.

scientific article

Lack of adrenomedullin affects growth and differentiation of adult neural stem/progenitor cells

scientific article published on 25 February 2010

Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage.

scientific article published on 19 September 2016

Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity.

scientific article published in October 2010

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

scholarly article

Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model.

scientific article

Local production and action of adrenomedullin in the rat adrenal zona glomerulosa

scientific article published in March 1998

Localization of adrenomedullin-like immunoreactivity in the hypothalamo-hypophysial system of amphibians

scientific article published in February 1998

Macrocybin, a Natural Mushroom Triglyceride, Reduces Tumor Growth In Vitro and In Vivo through Caveolin-Mediated Interference with the Actin Cytoskeleton

scientific article published on 18 December 2020

Mapping of the adrenomedullin-binding domains in human complement factor H.

scientific article published in February 2003

Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model

scientific article

Methylene blue prevents retinal damage in an experimental model of ischemic proliferative retinopathy

scientific article published on 16 March 2016

Microscopic study of the pyloric caeca of the starfishMarthasterias glacialis (Echinodermata): Finding of endocrine cells

scientific article published in November 1989

Modulation of endometrial steroid receptors and growth regulatory genes by tamoxifen

scientific article published in May 2000

Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing.

scientific article

Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases

scientific article published on 02 January 2021

Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice

scientific article published in January 2004

Nitric oxide synthase in invertebrates

scientific article published on October 1995

Nitric oxide synthase-immunoreactive neurons in human and porcine respiratory tract

scientific article published in November 1993

Non-peptide small molecule regulators of lymphangiogenesis

scientific article

Oral doxycycline reduces pterygium lesions; results from a double blind, randomized, placebo controlled clinical trial

scientific article

Peptidylglycine alpha-amidating monooxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours

scientific article

Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia

scientific article

Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery.

scientific article published in May 2003

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

scientific article published on 06 May 2011

Presence of immunoreactive adrenomedullin in human and bovine milk

scientific article

Prevention of Bone Loss in a Model of Postmenopausal Osteoporosis through Adrenomedullin Inhibition

scientific article published on 30 June 2016

Proadrenomedullin N-terminal 20 peptide (PAMP) immunoreactivity in vertebrate juxtaglomerular granular cells identified by both light and electron microscopy.

scientific article published in November 1999

Proadrenomedullin N-terminal 20 peptide increases kinesin's velocity both in vitro and in vivo

scientific article published on 14 February 2012

Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth

scientific article published on September 2004

Reduced Adrenomedullin Parallels Microtubule Dismantlement in Frontotemporal Lobar Degeneration.

scientific article published on 18 April 2018

Regulation of insulin secretion and blood glucose metabolism by adrenomedullin

scientific article published on June 1996

Regulation of pancreatic physiology by adrenomedullin and its binding protein.

scientific article

Regulatory peptides in gastric endocrine cells of the rainbow trout Oncorhynchus mykiss: General distribution and colocalizations

scientific article published in June 1994

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

scientific article published on 17 June 2019

Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer.

scientific article published on 13 December 2017

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

scientific article

Some peptide-like colocalizations in endocrine cells of the pyloric caeca and the intestine of Oncorhynchus mykiss (Teleostei)

scientific article published in August 1992

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

scientific article

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

scientific article

Temporal Pattern Changes in Duodenal Protein Tyrosine Nitration Events in Response to Eimeria Acervulina Infection in Chickens.

scientific article

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients

scientific article published on 18 March 2016

The Mammalian Peptide Adrenomedullin Acts as a Growth Factor in Tobacco Plants

scientific article published on 12 April 2017

The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

scientific article

The contributions of Santiago Ramón y Cajal to cancer research - 100 years on.

scientific article published in November 2005

The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems

scientific article published in February 2007

The nervous system of the chicken proventriculus: an immunocytochemical and ultrastructural study

scientific article published in 2000

The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model

scientific article

The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung

scientific article (publication date: 13 June 2003)

Transcriptomic profiling explains racial disparities in pterygium patients treated with doxycycline.

scientific article

Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway

scientific article

Underlying disease stress augments plasma and tissue adrenomedullin (AM) responses to endotoxin: colocalized increases in AM and inducible nitric oxide synthase within pancreatic islets

scientific article published on 01 November 1999

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis

scientific article published on 25 January 2013

Where does amidation take place?

scientific article published on October 1996

Whole-body periodic acceleration reduces brain damage in a focal ischemia model.

scientific article published on 14 December 2008

bFGF interaction and in vivo angiogenesis inhibition by self-assembling sulfonic acid-based copolymers

scientific article published on 25 November 2011

β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.

scientific article

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