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List of works by Guido Iaccarino

"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors

scientific article

A Novel Small Peptide Inhibitor of NFB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer

scientific article published on 04 November 2018

A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients

scientific article published on 18 January 2012

A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity.

scientific article

A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells

scientific article

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

scientific article

Active and Healthy Ageing and Independent Living 2016.

scientific article published on 12 October 2016

Active and Healthy Ageing and Independent Living.

scientific article

Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling.

scientific article

Adenoviral-mediated inhibition of G beta gamma signaling limits the hyperplastic response in experimental vein grafts

scientific article published on 01 August 1998

Adrenergic mechanism in the control of endothelial function

scientific article published on September 2011

Adrenergic receptors and metabolism: role in development of cardiovascular disease

scientific article published on 03 October 2013

Adrenergic signaling in heart failure and cardiovascular aging

scientific article published on 26 March 2016

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor

scientific article

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

scientific article

Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice ⬇️

scientific article published on 25 March 2019

Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes

scientific article

Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.

scientific article published on 21 June 2017

Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.

scientific article published on July 1996

Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.

scientific article published on 25 May 2011

Atrial fibrillation and microRNAs

scientific article published on 24 January 2014

Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension

scientific article

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

scientific article published on January 2017

CaMK4 Gene Deletion Induces Hypertension

scientific article

CaMKII protects MKP-1 from proteasome degradation in endothelial cells

scientific article published on 05 July 2014

Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs

scientific article published on 22 October 2017

Cardiac eccentric remodeling in patients with rheumatoid arthritis.

scientific article

Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment.

scientific article

Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.

scientific article published on 5 November 2016

Characterization of a selective CaMKII peptide inhibitor

scientific article published on 22 January 2013

Correction of erythrocyte shape abnormalities in familial hypercholesterolemia after LDL-apheresis: Does it influence cerebral hemodynamics?

scientific article published on 01 January 1997

Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

scientific article published on 26 October 2020

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors

scientific article

Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity.

scientific article published on 7 March 2018

Difficult-to-control hypertension: identification of clinical predictors and use of ICT-based integrated care to facilitate blood pressure control

scientific article published on 01 May 2018

Digitally Enabled Health Service for the Integrated Management of Hypertension: A Participatory User-Centred Design Process

scientific article published on 29 November 2021

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

scientific article published on 23 February 2014

Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.

scientific article published in October 2008

Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion

scientific article published on 01 January 1996

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

scientific article published on 29 July 2005

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species

scientific article published on 15 August 2013

Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.

scientific article

Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients

scientific article published on December 2008

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase

scientific article

Erratum to: Association Study between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population

scientific article published on 01 December 2017

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

scientific article (publication date: 2011)

Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.

scientific article

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation

scientific article published on 08 June 2007

Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis

scientific article published on 26 November 2020

Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice ⬇️

scientific article published on June 9, 1998

External support modulates G protein expression and receptor coupling in experimental vein grafts

scientific article published on 01 August 1999

Functional Role of Mitochondria in Arrhythmogenesis.

scientific article

G Protein-Coupled Receptor Kinase 2 in Patients With Acute Myocardial Infarction

scientific article published on 04 February 2011

G beta gamma-mediated signaling: new therapeutic target for proliferative vascular disease.

scientific article

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

scientific article

G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms

scientific article published on 27 March 2013

G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine

scientific article published on 01 October 2009

GRK2 Levels in Umbilical Arteries of Pregnancies Complicated by Gestational Hypertension and Preeclampsia

scientific article published on 01 March 2012

GRK2 at the control shaft of cellular metabolism.

scientific article

GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion

scientific article published on 14 February 2018

Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

scientific article published on 06 October 2020

Gene-environment interactions and vitamin D effects on cardiovascular risk

scientific article published on 30 August 2019

Good at Heart: Preserving Cardiac Metabolism during aging.

scientific article published on 22 July 2015

Growth hormone prolongs survival in experimental postinfarction heart failure

scientific article published on 01 June 2003

Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor

scientific article

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

scientific article published on 13 November 2017

Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factors

scientific article published on February 2011

In Vivo Adenoviral-Mediated Gene Transfer of the βARKct to Study the Role of Gβγ in Arterial Restenosis

scientific article published on January 1, 2004

In vivo properties of the proangiogenic peptide QK

scientific article published on 08 June 2009

Inflammation and Cardiovascular Diseases: The Most Recent Findings

scientific article published on 09 August 2019

Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.

scientific article published on 9 January 2016

Influence of digitalis on left ventricular functional response to exercise in congestive heart failure.

scientific article published in March 1996

Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease

scientific article published in May 2012

Insufficient control of blood pressure and incident diabetes

scientific article published on 17 February 2009

Insulin Modulation of Vascular Reactivity Is Already Impaired in Prehypertensive Spontaneously Hypertensive Rats ⬇️

scientific article published on August 1, 1995

Insulin Modulation of β-Adrenergic Vasodilator Pathway in Human Forearm

scientific article published on 01 April 1996

Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury.

scientific article published on 9 September 2009

Integrated care pathways for airway diseases (AIRWAYS-ICPs).

scientific article published on 12 June 2014

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy

scientific article published on 30 July 2015

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

scientific article published on April 2011

Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression.

scientific article published on 26 July 2010

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

scientific article published on 01 January 2010

Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients

scientific article published on January 2017

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease.

scientific article published on 19 January 2007

Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness.

scientific article published in January 2017

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages

scientific article published on 10 September 2013

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

scientific article published on October 2011

Models for preclinical studies in aging-related disorders: One is not for all.

scientific article published on December 2015

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases ⬇️

scientific article published on 30 March 2019

New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

scientific article published on 28 September 2017

Novel therapeutic targets in metabolic disorders: from the bench to the bedside.

scientific article published on 13 May 2014

Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling

scientific article published on 01 February 1999

Opposite effects of β2-adrenoceptor gene deletion on insulin signaling in liver and skeletal muscle

scientific article published on 15 June 2017

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.

scientific article published on 30 September 2009

Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells

scientific article

Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications

scientific article published on 19 December 2018

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

scientific article published on 30 April 2020

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system.

scientific article published on 12 August 2013

Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes

scientific article published on 15 March 2013

Prescription Patterns of Antidiabetic Treatment in the Elderly. Results from Southern Italy

scientific article published on July 2015

Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats

scientific article published on 01 May 2007

Proceedings of the EIP on AHA: A3 Action Group on Frailty

scientific article published on December 2015

Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade ⬇️

scientific article published on October 27, 1998

Redesigning service delivery for hypertensive patients: a methodological guideline to improve the management of chronic diseases

scientific article

Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension

scientific article published on 07 April 2020

Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries

scientific article published on 10 January 2005

SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors

scientific article published in January 2014

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

scientific article published on 08 August 2012

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.

scientific article

Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing

article

Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide

scientific article

Targeting mitochondria as therapeutic strategy for metabolic disorders.

scientific article published on 13 March 2014

Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

scientific article

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy

scientific article published on 25 June 2015

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

scientific article

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors.

scientific article

The Antioxidant Therapy: New Insights in the Treatment of Hypertension.

scientific article published on 21 March 2018

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

scientific article

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha

scholarly article

The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events

scientific article

The Glu27 allele of the ??2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension

scientific article published on 01 November 2004

The Italian reference sites of the European innovation partnership on active and healthy ageing: Progetto Mattone Internazionale as an enabling factor.

scientific article published in January 2017

The Italian version of the quick mild cognitive impairment (Qmci-I) screen: normative study on 307 healthy subjects

article

The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients.

scientific article published in March 2007

The mechanisms of air pollution and particulate matter in cardiovascular diseases.

scientific article published on 16 March 2017

The possible role of chromosome X variability in hypertensive familiarity

scientific article published on 25 February 2016

The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis.

scientific article published on July 2005

Thyroid function predicts increased cardiovascular risk.

scientific article

To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator

scientific article

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.

scientific article published on 27 June 2011

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization

scientific article

Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets

scientific article published on April 2003

Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly

scientific article

Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence

scientific article

We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome

scientific article published on 23 November 2019

beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene.

scientific article published in January 2005

β2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension

scientific article published on 01 December 2006

β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis.

scientific article published on 15 February 2013

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