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List of works by Paul Wan Sia Heng

A Study of Moisture Sorption and Dielectric Processes of Starch and Sodium Starch Glycolate : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

scientific article published on 5 September 2017

A comparative study between conventional pan coater and quasi-continuous small batch coater on the stability of tablets containing acetylsalicylic acid.

scientific article

A mechanistic investigation on the utilization of lactose as a protective agent for multi-unit pellet systems

scientific article published on 18 December 2014

A novel preformulation tool to group microcrystalline celluloses using artificial neural network and data clustering.

scientific article

A novel time-controlled release system based on drug-resin complexes and elementary osmotic pump.

scientific article published in April 2008

A probe test method for determination of molten binder tack.

scientific article published in August 1999

A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronization

scientific article published on 01 April 2001

A study on in-line tablet coating--the influence of compaction and coating on tablet dimensional changes.

scientific article

A study on microwave-induced melt granulation in a single pot high shear processor

scientific article published on 01 January 2008

A study on the impact of hydroxypropyl methylcellulose on the viscosity of PEG melt suspensions using surface plots and principal component analysis.

scientific article

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen.

scientific article published on 16 June 2015

Aging and microwave effects on alginate/chitosan matrices.

scientific article published on 25 April 2005

Air-dictated bottom spray process: impact of fluid dynamics on granule growth and morphology

scientific article published on 01 July 2009

Alginate/starch composites as wall material to achieve microencapsulation with high oil loading.

scientific article published on 20 October 2008

An improved method for the measurement of colour uniformity in pellet coating.

scientific article published in February 2001

An investigation of the chick chorioallantoic membrane as an alternative model to various biological tissues for permeation studies

scientific article published on 16 August 2011

An investigation on the influence of a vinyl pyrrolidone/vinyl acetate copolymer on the moisture permeation, mechanical and adhesive properties of aqueous-based hydroxypropyl methylcellulose film coatings.

scientific article published in July 2004

Anti-tack action of polyvinylpyrrolidone on hydroxypropylmethylcellulose solution.

scientific article

Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia ⬇️

scientific article

Application of multidimensional scaling to preformulation sciences: a discriminatory tool to group microcrystalline celluloses.

scientific article published in October 2005

Application of near-infrared spectroscopy in real-time monitoring of product attributes of ribbed roller compacted flakes.

scientific article

Assessment of disintegration of rapidly disintegrating tablets by a visiometric liquid jet-mediated disintegration apparatus.

scientific article published on 7 September 2012

Buccal Delivery Systems ⬇️

scientific article published on September 1, 2003

Bulk Freeze-Drying Milling: a Versatile Method of Developing Highly Porous Cushioning Excipients for Compacted Multiple-Unit Pellet Systems (MUPS).

scientific article published on 10 October 2017

Calibration sampling paradox in near infrared spectroscopy: a case study of multi-component powder blend.

scientific article published on 22 May 2010

Characterization of spreadability of nonaqueous ethylcellulose gel matrices using dynamic contact angle.

scientific article

Characterizing the Surface Roughness Length Scales of Lactose Carrier Particles in Dry Powder Inhalers

scientific article published on 06 March 2018

Chick chorioallantoic membrane as an in situ biological membrane for pharmaceutical formulation development: a review

scientific article published in November 2008

Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts.

scientific article

Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model

scientific article published on 3 March 2006

Citric acid as a plasticizer for spray-dried microcapsules

scientific article published on 01 January 1993

Classification of annular bed flow patterns and investigation on their influence on the bottom spray fluid bed coating process.

scientific article published on 5 March 2010

Cluster formation and drag reduction-proposed mechanism of particle recirculation within the partition column of the bottom spray fluid-bed coater

scientific article published on 30 December 2014

Comparative evaluation of powder flow parameters with reference to particle size and shape

scientific article published on 24 May 2018

Comparative study of non-destructive methods to quantify thickness of tablet coatings

scientific article published on 22 July 2010

Comparative study of the fluid dynamics of bottom spray fluid bed coaters

scientific article published on 14 April 2006

Cone milling of compacted flakes: process parameter selection by adopting the minimal fines approach

scientific article published on 06 October 2011

Continuous processing and the applications of online tools in pharmaceutical product manufacture: developments and examples.

scientific article published on April 2013

Cross-linking mechanisms of calcium and zinc in production of alginate microspheres

scientific article published on 01 August 2002

Delivery of hypericin for photodynamic applications

scientific article

Design of a device for simultaneous particle size and electrostatic charge measurement of inhalation drugs.

scientific article published in July 2008

Design of controlled-release solid dosage forms of alginate and chitosan using microwave

scientific article published in December 2002

Determination of solid state characteristics of spray-congealed Ibuprofen solid lipid microparticles and their impact on sustaining drug release

scientific article published on 15 April 2015

Determination of the Nip Angle in Roller Compactors With Serrated Rolls

scientific article published in June 2016

Development and evaluation of optimized sucrose ester stabilized oleanolic acid nanosuspensions prepared by wet ball milling with design of experiments.

scientific article

Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization

scientific article published on 27 December 2006

Development of novel nonaqueous ethylcellulose gel matrices: rheological and mechanical characterization.

scientific article published on 7 April 2005

Development of potential novel cushioning agents for the compaction of coated multi-particulates by co-processing micronized lactose with polymers

scientific article published on 31 March 2011

Development of re-usable yeast-gellan gum micro-bioreactors for potential application in continuous fermentation to produce bio-ethanol

scientific article (publication date: 17 October 2011)

Dielectric properties of pharmaceutical materials relevant to microwave processing: effects of field frequency, material density, and moisture content

scientific article published on 01 February 2010

Dissolution of fine particle fraction from truncated Anderson cascade impactor with an enhancer cell

scientific article published on 22 April 2018

Distribution of a viscous binder during high shear granulation--sensitivity to the method of delivery and its impact on product properties

scientific article published on 20 November 2013

Drug encapsulation in alginate microspheres by emulsification

scientific article published on 01 July 1992

Drying efficiency and particle movement in coating--impact on particle agglomeration and yield.

scientific article published on 4 September 2007

Effect of Lipid Additives and Drug on the Rheological Properties of Molten Paraffin Wax, Degree of Surface Drug Coating, and Drug Release in Spray-Congealed Microparticles

scientific article published on 26 June 2018

Effect of hydration on the structure of non aqueous ethyl cellulose/propylene glycol dicaprylate gels.

scientific article

Effect of moisture sorption on the performance of crospovidone.

scientific article published in November 2016

Effect of off-bottom clearance on properties of pellets produced by melt pelletization

scientific article published on 01 January 1999

Effect of oil loading on microspheres produced by spray drying

scientific article published in May 2005

Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization.

scientific article published on 15 June 2010

Effects of aldehydes and methods of cross-linking on properties of calcium alginate microspheres prepared by emulsification.

scientific article published in March 2002

Effects of physical properties of PEG 6000 on pellets produced by melt pelletization

scientific article published on 01 August 1999

Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification

scientific article published on 01 July 1998

Elucidation of monomerization effect of PVP on chlorin e6 aggregates by spectroscopic, chemometric, thermodynamic and molecular simulation studies

scientific article published on 17 May 2013

Encapsulation of volatiles by homogenized partially-cross linked alginates

scientific article published on 12 November 2015

Energy-based analysis of cone milling process for the comminution of roller compacted flakes.

scientific article published on 27 December 2013

Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.

scientific article published on 28 July 2005

Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels.

scientific article published in February 2005

Evaluation of coat uniformity and taste-masking efficiency of irregular-shaped drug particles coated in a modified tangential spray fluidized bed processor.

scientific article published on 8 June 2015

Evaluation of the coat quality of sustained release pellets by individual pellet dissolution methodology

scientific article published on 27 November 2014

Evaluation of the physicochemical properties and compaction behavior of melt granules produced in microwave-induced and conventional melt granulation in a single pot high shear processor.

scientific article published on 18 October 2011

Ex-vivo permeation study of chlorin e6-polyvinylpyrrolidone complexes through the chick chorioallantoic membrane model

scientific article published on 18 February 2014

Feasibility of eliminating premixing for the production of pellets in a rotary processor

scientific article published on 01 January 2006

Feasibility study on microencapsulation of anaerobic Clostridium acetobutylicum ATCC 824 by emulsification method for application in biobutanol production

scientific article published on 3 April 2014

Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6–polyvinylpyrrolidone

scientific article published on 20 March 2006

Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view

scientific article published on 31 December 2015

Formulation, Biological and Pharmacokinetic Studies of Sucrose Ester-Stabilized Nanosuspensions of Oleanolic Acid ⬇️

scientific article published on April 9, 2011

Functionality of disintegrants and their mixtures in enabling fast disintegration of tablets by a quality by design approach

scientific article

Hot melt extrusion of ion-exchange resin for taste masking

scientific article published on 30 May 2018

Impact of Electrostatics on Processing and Product Performance of Pharmaceutical Solids.

scientific article published on 08 October 2015

Impact of HPMC on the physical properties of spray-congealed PEG microparticles and its swelling effect on rifampicin dissolution.

scientific article published on 13 July 2015

Impact of a non-meltable additive on melt agglomeration with a hydrophobic meltable binder in high-shear mixer

scientific article published on 01 January 2007

Impact of cross-linker on alginate matrix integrity and drug release

scientific article published on 05 January 2008

Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer

scientific article

Improving Dry Powder Inhaler Performance by Surface Roughening of Lactose Carrier Particles

scientific article published on 18 April 2016

In-line quantification of micronized drug and excipients in tablets by near infrared (NIR) spectroscopy: Real time monitoring of tabletting process.

scientific article published on 15 June 2010

In-vivo optical detection of cancer using chlorin e6--polyvinylpyrrolidone induced fluorescence imaging and spectroscopy.

scientific article

Influence of Hydroxypropyl Methylcellulose on Metronidazole Crystallinity in Spray-Congealed Polyethylene Glycol Microparticles and Its Impact with Various Additives on Metronidazole Release

scientific article

Influence of disintegrants in different substrate physical form on dimensional recovery of multi-component tablet

scientific article published on 08 September 2014

Influence of particle wall adhesion on particle electrification in mixers.

scientific article published on 29 July 2006

Influence of production variables on the sphericity of melt pellets.

scientific article published in March 2000

Influence of rate of force application during compression on tablet capping.

scientific article

Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press.

scientific article published on 11 November 2016

Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug

scientific article published on 06 November 2020

Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization.

scientific article

Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers.

scientific article published on 26 June 2008

Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate.

scientific article

Investigation of the milling capabilities of the F10 Fine Grind mill using Box-Behnken designs

scientific article published on 10 December 2014

Investigation of wetting behavior of nonaqueous ethylcellulose gel matrices using dynamic contact angle.

scientific article published on 12 January 2006

Investigation on Side-Spray Fluidized Bed Granulation with Swirling Airflow ⬇️

scientific article published on December 21, 2012

Layered growth with bottom-spray granulation for spray deposition of drug

scientific article published on 06 May 2009

Long-acting contraceptive agents: norethisterone esters of arylcarboxylic acids

scientific article published on 01 March 1983

Mechanism of pellet coat rupture and its effect on drug release

scientific article published on 01 July 1999

Mechanistic study on hydration and drug release behavior of sodium alginate compacts

scientific article published in June 2007

Meeting report: the 1st BRG-training school in Asia, a first step in the building of an ASEAN encapsulation network.

scientific article published on 6 November 2014

Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model

scientific article

Microwave drying of granules containing a moisture-sensitive drug: a promising alternative to fluid bed and hot air oven drying

scientific article (publication date: July 2005)

Mixed polymer coating for modified release from coated spheroids

scientific article published in January 1999

New indices to characterize powder flow based on their avalanching behavior.

scientific article published in February 2006

Novel polymeric microspheres containing norcantharidin for chemoembolization.

scientific article published on 8 September 2006

Optimization in solvent selection for chlorin e6 in photodynamic therapy.

scientific article

Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments.

scientific article

Physico-chemical aspects of lactose for inhalation ⬇️

scientific article published on November 15, 2011

Plasticizers and their effects on microencapsulation process by spray-drying in an aqueous system

scientific article published on 01 January 1992

Potentiation of the photodynamic action of hypericin.

scientific article published on January 2008

Powder Flow Testing: Judicious Choice of Test Methods

scientific article published on 14 November 2016

Powder dispersion mechanisms within a dry powder inhaler using microscale particle image velocimetry.

scientific article

Pre-formulation studies on moisture absorption in microcrystalline cellulose using differential thermo-gravimetric analysis.

scientific article published in April 2004

Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed.

scientific article

Process analytical technology: application to particle sizing in spray drying.

scientific article

Production of alginate microspheres by internal gelation using an emulsification method.

scientific article published in August 2002

Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate.

scientific article published in March 2000

Relationship between polymer viscosity and drug release from a matrix system

scientific article published on 01 November 1992

Review of Disintegrants and the Disintegration Phenomena

scientific article

Role of solvent in interactions between fatty acids-based formulations and lipids in porcine stratum corneum.

scientific article published in January 2004

Roller compaction of crude plant material: influence of process variables, polyvinylpyrrolidone, and co-milling

scientific article published on 01 January 2004

Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations

scientific article published on 14 August 2006

Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: the effect of matrix type, polymeric additives and drug-matrix miscibility

scientific article published on 04 August 2015

Stability of a novel corticosteroid nasal irrigation solution: betamethasone 17-valerate added to extemporaneously prepared nasal irrigation solutions.

scientific article published on 16 January 2017

Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques.

scientific article

Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.

scientific article published on 28 November 2006

Tablet compression tooling - Impact of punch face edge modification.

scientific article published on 4 April 2017

The CAM-LDPI method: a novel platform for the assessment of drug absorption ⬇️

scientific article published on December 29, 2011

The butterfly effect: A physical phenomenon of hypromellose matrices during dissolution and the factors affecting its occurrence ⬇️

scientific article published on December 25, 2010

The chick chorioallantoic membrane imaging method as a platform to evaluate vasoactivity and assess irritancy of compounds

scientific article published on 16 March 2012

The effect of moisture on the cohesive properties of microcrystalline celluloses

scientific article published on 01 May 1988

The influence of microcrystalline cellulose grade on shape and shape distributions of pellets produced by extrusion-spheronization

scientific article published on 01 November 2001

The potential application of chlorin e6–polyvinylpyrrolidone formulation in photodynamic therapy

scientific article published on 21 September 2006

The reality of in-line tablet coating.

scientific article published on 08 June 2011

Torque rheological parameters to predict pellet quality in extrusion-spheronization.

scientific article published on 6 March 2006

Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment

scientific article published in June 2005

Understanding die fill variation during mini-tablet production.

scientific article published on 23 October 2017

Understanding effects of process parameters and forced feeding on die filling

scientific article published on 27 June 2018

Use of a fluidized bed hammer mill for size reduction and classification: effects of process variables and starting materials on the particle size distribution of milled lactose batches.

scientific article published in January 2003

Use of swirling airflow to enhance coating performance of bottom spray fluid bed coaters

scientific article published on 20 July 2006

[Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].

scientific article

pH-dependent complexation of hydroxypropyl-beta-cyclodextrin with chlorin e6: effect on solubility and aggregation in relation to photodynamic efficacy.

scientific article published on 04 March 2016

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