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List of works by Michael J Strong

14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3' UTR.

scientific article published on 13 November 2006

A 58-year-old woman with progressive vertigo, deafness and weakness

scientific article published in February 2005

A morphological analysis of the motor neuron degeneration and microglial reaction in acute and chronic in vivo aluminum chloride neurotoxicity

scientific article

ALS--not what we thought

scientific article published on 01 March 2006

Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro.

scientific article published on July 2002

Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice.

scientific article published in February 2004

Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels

scientific article published on 24 May 2013

Aluminum neurotoxicity: an experimental approach to the induction of neurofilamentous inclusions.

scientific article published on July 1994

Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα.

scientific article published on 10 September 2017

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.

scientific article published on 5 January 2017

Amyotrophic lateral sclerosis: a review of current concepts.

scientific article

Amyotrophic lateral sclerosis: contemporary concepts in etiopathogenesis and pharmacotherapy

scientific article

An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology

scientific article published on February 2008

Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis

scientific article (publication date: 2014)

Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers

scientific article published on 2 May 2014

Ataxin-2 repeat-length variation and neurodegeneration

scientific article

C9ORF72 repeat expansions in cases with previously identified pathogenic mutations

scientific article published on 11 September 2013

C9orf72 hexanucleotide repeat expansions as the causative mutation for chromosome 9p21-linked amyotrophic lateral sclerosis and frontotemporal dementia

scientific article published on 01 September 2012

C9orf72 mutations do not influence the tau signature of amyotrophic lateral sclerosis with cognitive impairment (ALSci).

scientific article

Cerebral haemodynamic changes accompanying cognitive impairment in primary lateral sclerosis.

scientific article

Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease.

scientific article published on April 2015

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

scientific article

Chronic aluminum-induced motor neuron degeneration: clinical, neuropathological and molecular biological aspects

scientific article (publication date: August 1991)

Cognition, language, and speech in amyotrophic lateral sclerosis: a review.

scientific article published on April 1996

Cognitive impairment in sporadic ALS: a pathologic continuum underlying a multisystem disorder

scientific article published on 01 August 2001

Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis.

scientific article published in December 1996

Comprehensive luciferase-based reporter gene assay reveals previously masked up-regulatory effects of miRNAs

scientific article published on 3 September 2014

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis.

scientific article published in June 2009

Correction to "RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis"

scientific article published on 08 May 2018

Creutzfeldt-Jakob disease presenting with visual manifestations

scientific article published on 01 October 2008

Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.

scientific article

Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.

scientific article

Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis

scientific article published on 4 January 2013

Diagnosis of Inclusion

scientific article published on 01 March 2015

Differentiation between primary lateral sclerosis and amyotrophic lateral sclerosis: examination of symptoms and signs at disease onset and during follow-up

scientific article

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury

scientific article published on 01 November 2008

Dose-dependent selective suppression of light (NFL) and medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity.

scientific article published on August 1994

Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

scientific article published on 20 July 2018

Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype

scientific article published on 04 March 2021

Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord.

scientific article

Factors correlated with NPPV use in ALS

scientific article published on 01 June 2006

Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis.

scientific article

Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia

scientific article published on 27 June 2012

Genetic and epigenetic studies of amyotrophic lateral sclerosis

scientific article published on May 2013

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

scientific article

Hemiageusia, hemianaesthesia and hemiatrophy of the tongue

scientific article published on 01 May 1986

Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans

scientific article published in January 2010

Impaired proteasome function in sporadic amyotrophic lateral sclerosis.

scientific article published in June 2012

Increasing peak expiratory flow time in amyotrophic lateral sclerosis.

scientific article published in January 2005

Innate immunity in amyotrophic lateral sclerosis.

scientific article

Intermediate filament steady-state mRNA levels in amyotrophic lateral sclerosis.

scientific article published in April 2004

Isolation of fetal mouse motor neurons on discontinuous Percoll density gradients

scientific article published on 01 October 1989

Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS

scientific article published on 08 April 2007

Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis

scientific article published on 01 July 2009

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

scientific article published on 26 July 2012

Longitudinal Changes in Discourse Prouction in Amyotrophic Lateral Sclerosis

scientific article published on 23 February 2012

Longitudinal Discourse Changes in Amyotrophic Lateral Sclerosis

Metabolic changes in human muscle denervation: topical 31P NMR spectroscopy studies

scientific article published on 01 August 1988

Methods for estimating numbers of motor units in biceps-brachialis muscles and losses of motor units with aging.

scientific article published on May 1988

MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS)

scientific article published on 29 October 2018

Microtubule-associated tau protein positive neuronal and glial inclusions in ALS.

scientific article published on December 2003

Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology

scientific article

Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits

scientific article published on 01 April 2000

Motor unit estimates in the biceps-brachialis in amyotrophic lateral sclerosis.

scientific article published on May 1988

Multiple cerebral infarcts in patient with Moyamoya disease

scientific article published on May 2012

N-Butyl benzenesulfonamide: a neurotoxic plasticizer inducing a spastic myelopathy in rabbits

scientific article published on 01 January 1991

N-butylbenzenesulphonamide, a novel neurotoxic plasticising agent

scientific article published on 01 September 1990

NIPPV: prevalence, approach and barriers to use at Canadian ALS centres.

scientific article

NMDA induces NOS 1 translocation to the cell membrane in NGF-differentiated PC 12 cells.

scientific article published in June 2003

Neurofilament metabolism in sporadic amyotrophic lateral sclerosis.

scientific article

Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis.

scientific article published on December 1998

Novel miR-b2122 regulates several ALS-related RNA-binding proteins.

scientific article published on 2 October 2017

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation ⬇️

scientific article published on May 21, 2011

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy

scientific article published on 31 March 2016

Percutaneous endoscopic gastrostomy (PEG) in patients with ALS and bulbar dysfunction.

scientific article

Percutaneous gastrojejunostomy in amyotrophic lateral sclerosis

scientific article

Phase II/III randomized trial of TCH346 in patients with ALS

scientific article (publication date: 21 August 2007)

Post-transcriptional control of neurofilaments in development and disease.

scientific article published on 27 February 2007

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the Am

scientific article

Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum?

scientific article

Prognosis of amyotrophic lateral sclerosis with respiratory onset.

scientific article

Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression.

scientific article

Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ

scientific article

RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis

scientific article published on 22 March 2018

RNA metabolism in ALS: when normal processes become pathological.

scientific article published on 20 February 2014

RNA-binding proteins as molecular links between cancer and neurodegeneration.

scientific article published on 18 September 2014

Recurrent encephalopathy: NAGS (N-acetylglutamate synthase) deficiency in adults.

scientific article

Regional spread pattern predicts survival in patients with sporadic amyotrophic lateral sclerosis.

scientific article published on 17 January 2012

Reversibility of neurofilamentous inclusion formation following repeated sublethal intracisternal inoculums of AlCl3 in New Zealand white rabbits

scientific article published on 01 January 1995

Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis ⬇️

scientific article published on July 24, 2012

Selective loss of trans-acting instability determinants of neurofilament mRNA in amyotrophic lateral sclerosis spinal cord

scientific article published on 01 May 2003

Sleep-disordered breathing in amyotrophic lateral sclerosis.

scientific article published on September 1996

Spinal motor neuron neuroaxonal spheroids in chronic aluminum neurotoxicity contain phosphatase-resistant high molecular weight neurofilament (NFH).

scientific article published in April 1996

Strategies for Supporting Physician-Scientists in Faculty Roles: A Narrative Review With Key Informant Consultations.

scientific article published on 8 August 2017

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

scientific article published on 08 November 2019

TAU mutations are not a predominant cause of frontotemporal dementia in Canadian patients

scientific article published on 01 August 2004

TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

scientific article published on 27 December 2019

TDP‐43 and FUS/TLS: sending a complex message about messenger RNA in amyotrophic lateral sclerosis? ⬇️

scientific article published on 06 September 2011

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia

scientific article published on 03 January 2014

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

scientific article published on 6 October 2009

Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.

scientific article published on May 2005

Tau protein phosphorylation at Thr175 initiates fibril formation via accessibility of the N-terminal phosphatase-activating domain

scientific article published on 19 December 2019

Temporal profiles of neuronal degeneration, glial proliferation, and cell death in hNFL(+/+) and NFL(-/-) mice

scientific article published on 01 October 2005

The ALS Patient Care Database: insights into end-of-life care in ALS.

scientific article published in December 2001

The Ontario Neurodegenerative Disease Research Initiative (ONDRI).

scientific article published on 22 December 2016

The basic aspects of therapeutics in amyotrophic lateral sclerosis

scientific article

The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.

scientific article

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).

scientific article published on 18 October 2009

The frontotemporal syndromes of ALS. Clinicopathological correlates.

scientific article published on 02 August 2011

The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis.

scientific article published on December 2008

The temporal expression of amyloid precursor protein mRNA in vitro in dissociated hippocampal neuron cultures.

scientific article published in August 1990

Three families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p.

scientific article published in February 2007

Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

scientific article published on 11 January 2017

Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: a novel model of neuroinflammation

scientific article published on 7 July 2008

Upregulation of GSK3beta expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)

scientific article published on 24 January 2008

Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis.

scientific article published in February 2012

Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment.

scientific article

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