List of works - Emmet McCormack

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 16 March 2018

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

scientific article published on 12 October 2016

A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients

article

Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death

scientific article published on 8 January 2008

Animal models of acute myelogenous leukaemia - development, application and future perspectives.

scientific article

Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

scientific article published on December 2016

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

scientific article published on 23 April 2018

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

scientific article

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

scientific article published on 22 December 2012

CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma

scientific article published on 23 May 2020

Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid

scientific article published on 14 November 2012

Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients.

scientific article published on 26 July 2007

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

scientific article

Erythropoietin a safe bet in haemorrhagic shock?

scientific article published on 01 May 2008

Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds

scientific article published on 14 August 2015

Expression of TP53 isoforms p53β or p53γ enhances chemosensitivity in TP53(null) cell lines.

scientific article

First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma

scientific article

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.

scientific article

Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling

scientific article

High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma.

scientific article

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

scientific article published on 23 January 2016

Immunotherapy in chronic lymphocytic leukemia

scientific article

Implantable microenvironments to attract hematopoietic stem/cancer cells.

scientific article

In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.

scientific article published in May 2013

In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization.

scientific article

Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model

scientific article published on August 2009

Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors

scientific article published on 26 February 2016

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

scientific article published on 23 December 2019

Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

scientific article published on 06 July 2019

Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?

scientific article

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

scientific article

Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia

scientific article published on January 2010

Leukocyte p53 protein biosignature through standard-aligned two-dimensional immunoblotting

scientific article published on 26 July 2012

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.

scientific article

MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells

scientific article published on 27 February 2013

Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin

scientific article published on 18 November 2011

Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia

scientific article published on 20 May 2019

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

scientific article

Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma

scientific article published on 7 August 2015

Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia

scientific article published on 12 December 2012

Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes.

scientific article

Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer

scientific article published on 10 December 2012

Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma

scientific article published on 21 February 2019

Proceedings from the 1st Insights in Hematology Symposium, Cluj-Napoca, Romania March 11-12, 2016.

scientific article published in September 2016

Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.

scientific article published on 27 September 2009

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 22 May 2018

Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

scientific article published on 20 October 2010

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

scientific article

Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma

scientific article published on 18 November 2016

Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.

scientific article published on February 2014

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

scientific article published on 14 July 2010

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.

scientific article

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

scientific article published on September 2013

The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

scientific article

Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.

scientific article published on 13 April 2018

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

scientific article

Xenograft Models of Primary Acute Myeloid Leukemia for the Development of Imaging Strategies and Evaluation of Novel Targeted Therapies

scientific article published on 16 August 2015

List of works by Emmet McCormack

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients

Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death

Animal models of acute myelogenous leukaemia - development, application and future perspectives.

Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma

Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid

Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients.

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

Erythropoietin a safe bet in haemorrhagic shock?

Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds

Expression of TP53 isoforms p53β or p53γ enhances chemosensitivity in TP53(null) cell lines.

First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.

Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling

High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma.

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

Immunotherapy in chronic lymphocytic leukemia

Implantable microenvironments to attract hematopoietic stem/cancer cells.

In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.

In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization.

Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model

Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia

Leukocyte p53 protein biosignature through standard-aligned two-dimensional immunoblotting

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.

MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells

Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin

Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma

Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia

Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes.

Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer

Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma

Proceedings from the 1st Insights in Hematology Symposium, Cluj-Napoca, Romania March 11-12, 2016.

Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma

Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

Xenograft Models of Primary Acute Myeloid Leukemia for the Development of Imaging Strategies and Evaluation of Novel Targeted Therapies