List of works by Bas J Blaauboer

13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies and conceptual issues.

scientific article

A modified method of blood sampling from birds

scientific article published on October 1978

A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.

scientific article published on 27 July 2013

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

scientific article published on January 2012

A spectrophotometric assay for the detection of 2-aminophenols in biological samples

scientific article published on 01 July 1994

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme.

scientific article published on 27 February 2018

Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes.

scientific article

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.

scientific article published on 6 January 2017

An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project.

scientific article

An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer's disease and neurodegeneration

scientific article

An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing

scientific article published on 01 August 2005

Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies

scientific article published on 01 May 1994

Application of high-performance liquid chromatographic analysis of scoparone and its metabolites in the study of cytochrome P450 differentiation in vitro

scientific article published on 01 February 1989

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.

scientific article published on 10 December 2012

Attachment of rat hepatocytes to plastic substrata in the absence of serum requires protein synthesis

scientific article published on 01 September 1979

Biochemical processes involved in ferrihemoglobin formation by monohydroxyaniline derivatives in erythrocytes of birds and mammals

scientific article

Biokinetic modeling and in vitro-in vivo extrapolations

scientific article

Biokinetics in repeated-dosing in vitro drug toxicity studies.

scientific article published on 8 September 2015

Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

scientific article

Biotransformation of scoparone used to monitor changes in cytochrome P450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys

scientific article published on 01 April 1991

CON4EI: CONsortium for in vitro Eye Irritation testing strategy

scientific article published on 01 June 2018

Comparative cytotoxicity of bromobenzene in primary cultures of rat and hamster hepatocytes and its relation to biotransformation

scientific article published on 01 January 1991

Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities

scientific article published on 01 July 1991

Computer-aided biokinetic modelling combined with in vitro data

scientific article

Considering new methodologies in strategies for safety assessment of foods and food ingredients

scientific article

Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle

scientific article published on 01 November 1993

Cytotoxicity of menadione and related quinones in freshly isolated rat hepatocytes: effects on thiol homeostasis and energy charge

scientific article published on 01 January 1993

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.

scientific article published on 11 March 2010

Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albumin.

scientific article

Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver

scientific article published on 01 January 1993

Editorial

scientific article published in December 2013

Editorial: proceedings of ESTIV 2008, the 15th International Congress on In Vitro Toxicology

scientific article published on 09 October 2009

Effect of alkylating and redox cycling quinones on insulin receptor autophosphorylation

scientific article published on 01 August 1994

Effect of diphenyl ether herbicides and oxadiazon on porphyrin biosynthesis in mouse liver, rat primary hepatocyte culture and HepG2 cells.

scientific article

Effect of the protoporphyrinogen oxidase-inhibiting herbicide fomesafen on liver uroporphyrin and heptacarboxylic porphyrin in two mouse strains

scientific article published on 01 July 1994

Effects of 1,2-dibromoethane on isolated hepatocytes: functional alterations and induction of lipid peroxidation

scientific article published on 01 June 1988

Effects of clofibric and beclobric acid in rat and monkey hepatocyte primary culture: influence on peroxisomal and mitochondrial beta-oxidation and the activity of catalase, glutathione S-transferase and glutathione peroxidase

scientific article published on 01 January 1994

Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat

scientific article published on 01 January 1992

Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures

scientific article published on 01 July 1992

Effects of phenylhydroxylamine and aminophenols in Japanese quail in vivo

scientific article published on 01 July 1980

Effects of retinoic acid on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced differentiation of in vitro cultured human keratinocytes

scientific article published in August 1994

Effects of sulphydryl reagents on the formation of the aniline metabolite 4-aminophenol and its sulphate and glucuronide conjugates in primary cultures of rat hepatocytes

scientific article published on 01 November 1989

Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potenc

scientific article published in June 1993

Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies

scientific article published on May 1992

Erratum: Regulatory Acceptance and Use of Serology for Inactivated Veterinary Rabies Vaccines

scientific article published on 01 January 2015

Evaluation of In Vitro-based simulations of toluene uptake and metabolism in rats

scientific article published on 01 October 1997

Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice.

scientific article published on 18 July 2011

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds.

scientific article published on 8 November 2013

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods.

scientific article

Excessive levels of diverse phytoestrogens can modulate steroidogenesis and cell migration of KGN human granulosa-derived tumor cells.

scientific article published on 7 July 2014

Ferrihemoglobin formation by monohydroxy aniline derivatives in erythrocytes of some avian species in comparison with mammals

scientific article published on 01 January 1976

Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes

scientific article published on 01 May 1983

Fourteenth international workshop on in vitro toxicology 2-5 October 2006.

scientific article published on 22 September 2007

Hepatic cytochrome P450 induction in goats. Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine, and on apoprotein and mRNA levels

scientific article published on 01 January 1993

Hepatocyte-based in vitro models and their application in pharmacotoxicology Report of an EC DGXII meeting with representatives of the European pharmaceutical industry

scientific article published on 01 October 1995

Immunohistochemical detection of cytochrome P450 isoenzymes in cultured human epidermal cells.

scientific article published on December 1990

In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.

scientific article published on 30 January 2013

In vitro neuroendocrine effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the AhR-expressing hypothalamic rat GnV-3 cell line.

scientific article published on 16 July 2013

In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death.

scientific article published on 6 December 2016

In vitro, ex vivo, in vivo toxicology, the terminology issue

scientific article published in December 2017

Induction of terminal differentiation in cultured human keratinocytes by polychlorinated aromatic hydrocarbons as measured by cell size analysis

scientific article published on April 1992

Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity

scientific article

Interactive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoids on proliferation and differentiation in cultured human keratinocytes: quantification of cross-linked envelope formation

scientific article published on 01 January 1995

Interindividual variation in biotransformation and cytotoxicity of bromobenzene as determined in primary hepatocyte cultures derived from monkey and human liver

scientific article published on 01 June 1994

Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions

scientific article published on 01 January 1992

Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes. Reinvestigation of assay conditions

scientific article published on 01 January 1987

Kinetics of the formation and secretion of the aniline metabolite 4-aminophenol and its conjugates by isolated rat hepatocytes

scientific article (publication date: 1984)

Leukemia from dermal exposure to cyclophosphamide among nurses in The Netherlands: quantitative assessment of the risk.

scientific article

Making sense of in vitro methods. Proceedings of the 18th ESTIV congress

scientific article published on 01 September 2015

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

scientific article published on 27 February 2013

Methods of in vitro toxicology

scientific article

NADH-ferrihemoglobin reductase in avian erythrocytes

article published in 1985

Naringenin (NAR) and 8-prenylnaringenin (8-PN) reduce the developmental competence of porcine oocytes in vitro.

scientific article published on 4 June 2014

Nitrosobenzene-induced ferrihemoglobin formation in Japanese quail erythrocytes. The significance of ferrihemoglobin reduction

scientific article published in January 1975

On the incorporation of chemical-specific information in risk assessment

scientific article published on 08 June 2008

Phenobarbital pretreatment in vivo and in vitro and the effect of hepatotoxicity of d-galactosamine in rat hepatocytes in culture

scientific article published on 01 October 1994

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

scientific article

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

scientific article published on 30 May 2015

Proceedings of the 17th ESTIV congress 2012

scientific article published on 31 October 2013

Proceedings of the sixteenth international workshop on in vitro toxicology

scientific article published on 12 June 2011

Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays.

scientific article published on 8 February 2012

Quantitative cytometry as a tool for toxicity assessment (27th annual workshop of the Scandinavian Society for Cell Toxicology).

scientific article published on 6 September 2010

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment

scientific article published on 11 February 2015

Rapid method for the determination and quantification of bromosulphophthalein and metabolites in cultured hepatocytes, culture media and bile by high-performance liquid chromatography

scientific article published on 01 November 1988

Reconstructed human epidermis models for irritant testing of medical devices

scientific article published on 22 January 2018

Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

scientific article published on 15 February 2014

Regulatory acceptance and use of 3R models: a multilevel perspective

scientific article published on 01 January 2012

Regulatory acceptance and use of serology for inactivated veterinary rabies vaccines

scientific article published on 4 May 2015

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe

scientific article published on 28 October 2014

Replacing the NIH test for rabies vaccine potency testing: a synopsis of drivers and barriers

scientific article published on 15 May 2014

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

scientific article published on 15 December 2010

Reversed phase high-performance liquid chromatography of heterocyclic aromatic N-oxides: application to measurement of N-oxidation by microsomes and rat hepatocytes in primary culture

scientific article published on 01 July 1980

Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-induced cytotoxicity in rat hepatocytes

scientific article published on 01 November 1994

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article published on 5 July 2013

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article

Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

scientific article published in October 2013

Sens-it-iv: a European Union project to develop novel tools for the identification of skin and respiratory sensitizers.

scientific article

Simulation of lindane kinetics in rats.

scientific article published in September 1997

Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo.

scientific article published in August 1996

Stem cell-derived systems in toxicology assessment

scientific article

Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro

scientific article published on 01 January 1991

Sulfadimidine metabolism in vitro: II. Comparative studies in cultured rat, goat, sheep and cattle hepatocytes

scientific article published on 01 December 1993

Sulphadimidine metabolism in vitro: I. Sex differences in acetylation and hydroxylation in cultured rat hepatocytes

scientific article published on 01 September 1993

The ECITTS integrated toxicity testing scheme: The application of in vitro test systems to the hazard assessment of chemicals.

scientific article published in August 1994

The European Registered Toxicologist (ERT): Current status and prospects for advancement

scientific article published on 22 June 2016

The Predict-IV project: Towards predictive toxicology using in vitro techniques.

scientific article published in December 2015

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man ⬇️

scientific article published on September 10, 2010

The concentration of cytochrome P-450 in human hepatocyte culture

scientific article published in 1985

The contribution of in vitro toxicity data in hazard and risk assessment: current limitations and future perspectives.

scientific article

The cytotoxicity of halothane in isolated hepatocytes: Evidence for two different mechanisms.

scientific article published in January 1988

The effect of beclobric acid and clofibric acid on peroxisomal beta-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes

scientific article published on 01 August 1990

The in vitro biokinetics of chlorpromazine and diazepam in aggregating rat brain cell cultures after repeated exposure.

scientific article published in September 2014

The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.

scientific article

The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers

scientific article published on 01 December 1990

The long and winding road of progress in the use of in vitro data for risk assessment purposes: From "carnation test" to integrated testing strategies

scientific article

The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative

scientific article published on 30 January 2007

Thirteenth International Workshop on In Vitro Toxicology.

scientific article published on 19 August 2005

Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation.

scientific article

Towards toxicity assessment without animals: 28th Workshop of SSCT and FINCOPA seminar 21-23 September 2011, Tampere, Finland

scientific article published on 21 March 2013

Toxicodynamic modelling and the interpretation of in vitro toxicity data

scientific article

Transport of chlorpromazine in the Caco-2 cell permeability assay: a kinetic study.

scientific article published on 25 June 2012

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