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List of works by Tamar Tchkonia

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

scientific article

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

scientific article published in 2022

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

scientific article published on 16 November 2020

Cellular senescence and senolytics: the path to the clinic

Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women

scientific article published on 27 June 2017

Cellular senescence drives age-dependent hepatic steatosis.

scientific article

Deleted in Breast Cancer 1 regulates cellular senescence during obesity

scientific article

Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype

scientific article

Growth hormone in adipose dysfunction and senescence

scientific article published on May 2015

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

scientific article

Identification of Senescent Cells in the Bone Microenvironment

scientific article published on 24 June 2016

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

scientific article

Inflammatory characteristics of adipose tissue collected by surgical excision vs needle aspiration

scientific article

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats

scientific article published on 15 October 2017

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

scientific article published on 27 May 2016

Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet

scientific article published on 17 September 2013

Regional differences in cellular mechanisms of adipose tissue gain with overfeeding ⬇️

scientific article published on October 4, 2010

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice

scientific article

Senolytic Drugs: From Discovery to Translation

scientific article published on 19 July 2020

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

scientific article published on 22 November 2017

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

scientific article published on 28 November 2014

The Way Forward: Translation

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

scientific article published on 10 August 2016

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice

scientific article published on 20 January 2021

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