List of works - Jun Aruga

A novel member of the Xenopus Zic family, Zic5, mediates neural crest development.

scientific article published in December 2000

A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis ⬇️

scientific article published on January 4, 2011

A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity.

scientific article

An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3

scientific article published in Scientific Reports

An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin

scientific journal article

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

scientific article

Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.

scientific article published in May 2001

Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions

scientific article

Chimeric and Molecular Genetic Analysis of Myelin-Deficient (Shiverer and Mld) Mutant Mice ⬇️

scientific article published on January 1, 1990

Comparative Genomics of the Zic Family Genes

scientific article published in January 2018

Comparative anatomy of marmoset and mouse cortex from genomic expression.

scientific article published in April 2012

Conservation and diversification of Msx protein in metazoan evolution.

scientific article

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice

scientific article (publication date: 2009)

Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse

scientific journal article

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.

scientific article published on 22 July 2014

Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain.

scientific article published on June 2007

Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice.

scientific article published on 15 October 2010

Expression of ZIC family genes in meningiomas and other brain tumors

scientific article

Expression pattern of annelid Zic in embryonic development of the oligochaete Tubifex tubifex.

scientific article published on 23 September 2008

Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain

scientific article

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

scientific article

Functional role of Zic2 phosphorylation in transcriptional regulation

scientific journal article

Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia

scientific article

Gli Protein Nuclear Localization Signal

scientific article published on January 1, 2012

Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene

article

Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.

scientific article

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

scientific article

IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos.

scientific article published on 7 June 2011

Identification and Characterization of Novel Conserved Domains in Metazoan Zic Proteins

scientific article published on 01 September 2018

Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth ⬇️

scientific article published on September 1, 2003

Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice

scientific journal article

Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia

scientific article

Inositol 1,4,5-trisphosphate (IP3) receptors

scientific article published on 01 January 1992

Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II

scientific journal article

Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.

scientific article published in February 2018

Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice

Lophotrochozoan Zic Genes.

scientific article published in January 2018

Molecular biology of myelin basic protein: gene rearrangement and expression of anti-sense RNA in myelin-deficient mutants

scientific article published on January 1, 1991

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins

scientific journal article

Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family

scientific journal article

Mouse Zic1 is involved in cerebellar development

scientific journal article

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives

scientific journal article

Myelin Basic Protein Gene and the Function of Antisense RNA in Its Repression in Myelin-Deficient Mutant Mouse ⬇️

scientific article published on February 1, 1991

Myogenic repressor I-mfa interferes with the function of Zic family proteins

scientific journal article

Novel Isoforms of Mouse Myelin Basic Protein Predominantly Expressed in Embryonic Stage ⬇️

scientific article published on April 1, 1993

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

scientific journal article

Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma

scientific article

Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses

scientific journal article

Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling

scientific article published in January 2018

SLITRK6 mutations cause myopia and deafness in humans and mice

scientific article

Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction.

scientific article

Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities

scientific journal article

Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3.

scientific article published in December 2003

Stability of folding structure of Zic zinc finger proteins.

scientific article published on 5 May 2009

The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs.

scientific article

The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation

scientific journal article

The inositol 1,4,5-trisphosphate receptor

scientific article published on January 1, 1992

The role of Zic genes in neural development.

scientific article published on June 2004

Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.

scientific article

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

scientific journal article

Upstream stimulatory factors, USF1 and USF2 are differentially expressed during Xenopus embryonic development.

scientific article published on 25 May 2008

Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry.

scientific article published in February 2002

Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue.

scientific article published in June 2001

Xenopus Zic 3, a primary regulator both in neural and neural crest development ⬇️

scientific article published on October 28, 1997

Xenopus Zic family and its role in neural and neural crest development ⬇️

scientific article published on July 1, 1998

Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway.

scientific article published on 26 October 2011

Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family.

scientific article published in December 2006

Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos

scientific article published on 01 March 2001

ZIC1 Function in Normal Cerebellar Development and Human Developmental Pathology.

scientific article published in January 2018

ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.

scientific article

Zic Family Proteins in Emerging Biomedical Studies

scientific article published in January 2018

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly

scientific article published in April 2008

Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors

scientific article

Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation

scientific journal article

Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.

scientific article

Zic2 controls cerebellar development in cooperation with Zic1

scientific journal article

Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients

scientific article published on 17 June 2011

Zic2 patterns binocular vision by specifying the uncrossed retinal projection

scientific journal article

Zic3 is involved in the left-right specification of the Xenopus embryo.

scientific article published in November 2000

List of works by Jun Aruga

A novel member of the Xenopus Zic family, Zic5, mediates neural crest development.

A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis ⬇️

A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity.

An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3

An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.

Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions

Chimeric and Molecular Genetic Analysis of Myelin-Deficient (Shiverer and Mld) Mutant Mice ⬇️

Comparative Genomics of the Zic Family Genes

Comparative anatomy of marmoset and mouse cortex from genomic expression.

Conservation and diversification of Msx protein in metazoan evolution.

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice

Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.

Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain.

Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice.

Expression of ZIC family genes in meningiomas and other brain tumors

Expression pattern of annelid Zic in embryonic development of the oligochaete Tubifex tubifex.

Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

Functional role of Zic2 phosphorylation in transcriptional regulation

Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia

Gli Protein Nuclear Localization Signal

Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene

Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos.

Identification and Characterization of Novel Conserved Domains in Metazoan Zic Proteins

Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth ⬇️

Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice

Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia

Inositol 1,4,5-trisphosphate (IP3) receptors

Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II

Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.

Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice

Lophotrochozoan Zic Genes.

Molecular biology of myelin basic protein: gene rearrangement and expression of anti-sense RNA in myelin-deficient mutants

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins

Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family

Mouse Zic1 is involved in cerebellar development

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives

Myelin Basic Protein Gene and the Function of Antisense RNA in Its Repression in Myelin-Deficient Mutant Mouse ⬇️

Myogenic repressor I-mfa interferes with the function of Zic family proteins

Novel Isoforms of Mouse Myelin Basic Protein Predominantly Expressed in Embryonic Stage ⬇️

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma

Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses

Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling

SLITRK6 mutations cause myopia and deafness in humans and mice

Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction.

Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities

Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3.

Stability of folding structure of Zic zinc finger proteins.

The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs.

The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation

The inositol 1,4,5-trisphosphate receptor

The role of Zic genes in neural development.

Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Upstream stimulatory factors, USF1 and USF2 are differentially expressed during Xenopus embryonic development.

Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry.

Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue.

Xenopus Zic 3, a primary regulator both in neural and neural crest development ⬇️

Xenopus Zic family and its role in neural and neural crest development ⬇️

Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway.

Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family.

Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos

ZIC1 Function in Normal Cerebellar Development and Human Developmental Pathology.

ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.

Zic Family Proteins in Emerging Biomedical Studies

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly

Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors

Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation

Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.

Zic2 controls cerebellar development in cooperation with Zic1

Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients

Zic2 patterns binocular vision by specifying the uncrossed retinal projection

Zic3 is involved in the left-right specification of the Xenopus embryo.