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List of works by Karl Y Hostetler

A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation.

scientific article published in November 2017

Abnormal membrane phospholipid content in subcellular fractions from the morris 7777 hepatoma ⬇️

scientific article published on August 23, 1976

Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures

scientific article

Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.

scientific article published on September 1997

Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.

scientific article

Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo

scientific article published on 27 April 2009

Aminoglycoside antibiotics inhibit lysosomal phospholipase A and C from rat liver in vitro

scientific article published on 01 March 1982

Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.

scientific article published on 24 August 2009

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters

scientific article published on 27 November 2006

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.

scientific article published on October 2009

Biosynthesis of bis(monoacylglycero)phosphate in liver and macrophage lysosomes

scientific article published on 01 January 1992

Biosynthesis of cardiolipin in liver mitochondria ⬇️

scientific article published on June 8, 1971

Cardiolipin synthase from mammalian mitochondria ⬇️

scientific article published on September 4, 1997

Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.

scientific article published in November 2004

Chloroquine treatment does not cause phospholipid storage by depleting rat liver lysosomes of acid phospholipase A.

scientific article published on May 1984

Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand

scientific article published on 3 December 2007

Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro

scientific article

Contribution of the pentose cycle to the metabolism of glucose in the isolated, perfused brain of the monkey ⬇️

scientific article published in January 1970

Cytidine diphosphate diglyceride analogs of antiretroviral dideoxynucleosides: evidence for release of dideoxynucleoside-monophosphates by phospholipid biosynthetic enzymes in rat liver subcellular fractions

scientific article published on 01 October 1991

Deficiency of carnitine palmitoyltransferase in transformed lymphoblasts from a patient having a deficiency of carnitine palmitoyltransferase in skeletal muscle

scientific article published on 01 May 1980

Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.

scientific article published on August 2004

Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo.

scientific article published on March 1991

Effect of cationic amphiphilic drugs on the hydrolysis of acidic and neutral phospholipids by liver lysosomal phospholipase A

scientific article published on 01 May 1984

Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.

scientific article published on 22 February 2008

Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice

scientific article

Effects of chloroquine and 4,4'-bis(diethylaminoethoxy)α,β-diethyldiphenylethane on the incorporation of [3H]glycerol into the phospholipids of rat liver lysosomes and other subcellular fractions, in vivo ⬇️

scientific article published on December 5, 1980

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

scientific article published on August 2003

Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.

scientific article published in April 2006

Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections.

scientific article published in December 2007

Evaluation of ODE-Bn-PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures

scientific article published on 26 December 2017

Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis.

scientific article published in January 1997

Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections

scientific article

Further studies on the formation of cardiolipin and phosphatidylglycerol in rat liver mitochondria. Effect of divalent cations and the fatty acid composition of CDP-diglyceride

scientific article published on March 24, 1975

Fusidic acid, HIV, and host cell toxicity

scientific article published on 01 May 1988

Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine ⬇️

scientific article (publication date: September 1992)

In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.

scientific article

In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.

scientific article published on 13 December 2006

In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone ⬇️

scientific article published on April 15, 1988

Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.

scientific article published in March 2003

Increased mitochondrial CTP: Phosphatidic acid cytidyltransferase in the 7777 hepatoma ⬇️

scientific article published on September 20, 1976

Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action

scientific article

Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

scientific article published on 13 October 2008

Inhibition of purified lysosomal phospholipase A1 by beta-adrenoceptor blockers

scientific article published on 01 February 1985

Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis.

scientific article published on 25 February 2011

Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.

scientific article

Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug.

scientific article published on 9 December 2011

Intravitreal crystalline drug delivery for intraocular proliferation diseases.

scientific article

Intravitreal pharmacokinetics in rabbits of the foscarnet lipid prodrug: 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA)

scientific article published on 01 March 1999

Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery.

scientific article published on August 1999

Lipid conjugates of antiretroviral agents: release of antiretroviral nucleoside monophosphates by a nucleoside diphosphate diglyceride hydrolase activity from rat liver mitochondria

scientific article published on 01 July 1991

Liposome entrapment enhances the hypocalcemic action of parenterally administered calcitonin

scientific article published on 01 August 1984

Mammalian cardiolipin biosynthesis

scientific article published on 01 January 1992

Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate

scientific article

Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system.

scientific article

Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species.

scientific article

Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype

scientific article

Novel mutations in the gene encoding very long-chain acyl-CoA dehydrogenase identified in patients with partial carnitine palmitoyltransferase II deficiency

scientific article published on 21 November 2012

Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice

scientific article published on 9 November 2006

Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.

scientific article published in July 2004

Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection

scientific article

Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.

scientific article published on February 2004

Partial Deficiency of Muscle Carnitine Palmitoyltransferase with Normal Ketone Production ⬇️

scientific article published on March 9, 1978

Pathways of glucose metabolism in the isolated islet of the goosefish in vitro

scientific article published on 01 November 1966

Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice ⬇️

scientific article published on December 1, 1994

Phospholipase C activity of rat tissues

scientific article published on 01 September 1980

Phospholipid prodrug inhibitors of the HIV protease. Antiviral activity and pharmacokinetics in rats.

scientific article published on October 1994

Phospholipid transfer activities in Morris hepatomas and the specific contribution of the phosphatidylcholine exchange protein

scientific article published on 01 August 1980

Propranolol inhibition of the neutral phospholipases A of rat heart mitochondria, sarcoplasmic reticulum and cytosol

scientific article published on 01 December 1987

Purification of lysosomal phospholipase A and demonstration of proteins that inhibit phospholipase A in a lysosomal fraction from rat kidney cortex

scientific article published on 01 October 1986

Purification of rat kidney lysosomal phospholipase A1

scientific article published on 01 January 1991

Rethinking Remdesivir: Synthesis of Lipid Prodrugs that Substantially Enhance Anti-Coronavirus Activity

scientific article published on 27 August 2020

Role of phospholipase A inhibition in amiodarone pulmonary toxicity in rats

scientific article published on 01 February 1986

Role of phospholipases in myocardial ischemia: effect of cardioprotective agents on the phospholipases A of heart cytosol and sarcoplasmic reticulum in vitro.

scientific article published on June 1989

Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir

scientific article

Spontaneous and protein-mediated intermembrane transfer of the antiretroviral liponucleotide 3'-deoxythymidine diphosphate diglyceride ⬇️

scientific article published on June 30, 1992

Studies on nucleotide diphosphate diacylglycerol specificity of acidic phospholipid biosynthesis in rat liver subcellular fractions

scientific article published on 01 June 1976

Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C

scientific article published on 01 May 1981

Subcellular and submitochondrial localization of the biosynthesis of cardiolipin and related phospholipids in rat liver ⬇️

scientific article published on March 23, 1972

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.

scientific article published on 28 November 2016

Synthesis and antiviral activity of 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT.

scientific article published on April 1994

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication

scientific article

Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.

scientific article published in January 2006

Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.

scientific article published on 10 October 2006

Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.

scientific article

Synthesis and in vitro activity of long-chain 5'-O-[(alkoxycarbonyl)phosphinyl]-3'-azido-3'-deoxythymidines against wild-type and AZT- and foscarnet-resistant strains of HIV-1.

scientific article published on August 1997

Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.

scientific article published on 30 November 2006

Synthesis, characterization and some properties of dideoxynucleoside analogs of cytidine diphosphate diacylglycerol

scientific article published on November 11, 1992

The effect of L-epinephrine and triamcinolone on the incorporation of acetate-2-14C and 32Pi into phospholipids and neutral lipids in liver slices from adrenalectomized rats, in vitro

scientific article published on 01 December 1970

The intracellular distribution and antiviral activity of amantadine.

scientific article published in July 1981

The mechanism of cardiolipin biosynthesis in liver mitochondria ⬇️

scientific article published on March 23, 1972

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