List of works by David A Harrison

'Lumping or splitting' in paediatric acute respiratory distress syndrome (PARDS)

scientific article published on 24 August 2018

A Comparison of Mortality From Sepsis in Brazil and England

article

A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES).

scientific article

A new measure of acute physiological derangement for patients with exacerbations of obstructive airways disease: the COPD and Asthma Physiology Score

scientific article published on 09 July 2007

A new risk prediction model for critical care: The Intensive Care National Audit & Research Centre (ICNARC) model*

article

A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT

A qualitative feasibility study to inform a randomised controlled trial of fluid bolus therapy in septic shock

scientific article published on 28 August 2017

A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators.

scientific article published on 08 May 2015

Accounting for Heterogeneity in Relative Treatment Effects for Use in Cost-Effectiveness Models and Value-of-Information Analyses.

scientific article published on 23 February 2015

Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database.

scientific article published on 25 August 2009

An evaluation of the clinical and cost-effectiveness of alternative care locations for critically ill adult patients with acute traumatic brain injury.

scientific article published on 18 May 2016

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value [...]

scientific article

An integrated approach to evaluating alternative risk prediction strategies: a case study comparing alternative approaches for preventing invasive fungal disease.

scientific article published on 11 November 2013

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study

scientific article published on 23 November 2018

Assessment and optimization of mortality prediction tools for admissions to pediatric intensive care in the United kingdom.

scientific article published in March 2006

Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial

scientific article published in August 2005

Association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult general critical care units: cohort study exploring the 'weekend effect'.

scientific article

Association of Intensive Care Unit Patient-to-Intensivist Ratios With Hospital Mortality.

scientific article published on 24 January 2017

COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland

scientific article published on 09 October 2020

Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database

scientific article

Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programm

scientific article published on 13 October 2008

Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database

scientific article published on January 2007

Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database

scientific article published on January 2006

Characteristics and Outcome of Cancer Patients Admitted to the ICU in England, Wales, and Northern Ireland and National Trends Between 1997 and 2013.

scientific article

Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database

scientific article

Characteristics and outcome of children admitted to adult intensive care units in England, Wales and Northern Ireland (1996-2011)

scientific article published on 09 July 2013

Characteristics of adolescents requiring intensive care in the United Kingdom: A retrospective cohort study

scientific article published on 18 January 2018

Children with dermatological conditions admitted to paediatric intensive care: analysis of a national clinical audit database.

scientific article published on 18 December 2015

Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database.

scientific article published on January 2006

Comparing mortality among adult, general intensive care units in England with varying intensivist cover patterns: a retrospective cohort study.

scientific article

Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.

scientific article

Correction to: Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain.

scientific article

Cost-Effectiveness Of Early Parenteral Versus Enteral Nutrition In Critically Ill Patients

scientific article

Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery

scientific article

Development and validation of a risk model for identification of non-neutropenic, critically ill adult patients at high risk of invasive Candida infection: the Fungal Infection Risk Evaluation (FIRE) Study

scientific article

Development and validation of risk models to predict outcomes following in-hospital cardiac arrest attended by a hospital-based resuscitation team.

scientific article

Development and validation of the new ICNARC model for prediction of acute hospital mortality in adult critical care

scientific article published on 21 November 2016

Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology-A Cohort Study Illustrating the Need for Standardized Reporting

scientific article published on 27 June 2016

Drotrecogin alfa (activated): real-life use and outcomes for the UK

scientific article published on 22 April 2008

Early acute kidney injury in Northern Ireland ICUs.

scientific article

Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit

scientific article published on 6 November 2015

Early peak temperature and mortality in critically ill patients with or without infection

scientific article published on 31 January 2012

Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection

scientific article published on 3 February 2015

Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis

scientific article

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial

scientific article published on 01 February 2019

Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review

scientific article published on June 2014

Effect of non-clinical inter-hospital critical care unit to unit transfer of critically ill patients: a propensity-matched cohort analysis

scientific article published on 03 October 2012

Effect of specialist retrieval teams on outcomes in children admitted to paediatric intensive care units in England and Wales: a retrospective cohort study

scientific article published on 11 August 2010

Effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route for critically ill adult patients

scientific article published on 26 August 2018

Effectiveness of ways to improve detection and rescue of deteriorating patients

scientific article published on March 2017

End-of-life decisions: a cohort study of the withdrawal of all active treatment in intensive care units in the United Kingdom

scientific article published on 27 April 2005

Epidemiology of admissions to 11 stand-alone high-dependency care units in the UK.

scientific article published on 10 September 2015

Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database.

scientific article published in October 2017

Estimating attributable fraction of mortality from sepsis to inform clinical trials.

scientific article published on 25 January 2018

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform

scientific article published on 30 April 2021

Evaluation of modernisation of adult critical care services in England: time series and cost effectiveness analysis

scientific article

Evaluation of the Effect of a Continuous Treatment: A Machine Learning Approach with an Application to Treatment for Traumatic Brain Injury.

scientific article published on 8 June 2015

Exploring challenges of RCTs in the emergency and critical care setting.

scientific article

Exploring the impact of using measured or estimated values for height and weight on the relationship between BMI and acute hospital mortality.

scientific article published on 15 November 2017

External Validation and Recalibration of Risk Prediction Models for Acute Traumatic Brain Injury among Critically Ill Adult Patients in the United Kingdom

scientific article

External validation of the Intensive Care National Audit & Research Centre (ICNARC) risk prediction model in critical care units in Scotland.

scientific article

FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care.

scientific article published on 4 June 2018

Factors that influence the way communities respond to proposals for major changes to local emergency services: a qualitative study

scientific article

Factors that influence the way local communities respond to consultation processes about major service change: A qualitative study.

scientific article

Genetic mechanisms of critical illness in Covid-19

scientific article published on 11 December 2020

Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe

scientific article (publication date: October 2013)

Health services research in critical care using administrative data.

scientific article

Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study

scientific article published in 2022

Hospitals' star ratings and clinical outcomes: ecological study.

scientific article published on 23 January 2004

How do information sources influence the reported Cerebral Performance Category (CPC) for in-hospital cardiac arrest survivors? An observational study from the UK National Cardiac Arrest Audit (NCAA)

scientific article published on 12 June 2019

Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain.

scientific article

Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units.

scientific article published on 5 January 2018

Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit

scientific article published on 15 April 2014

Increasing power in randomized controlled trials.

scientific article published in October 2009

Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation

scientific article published on 09 July 2016

Interventions to reduce mortality from in-hospital cardiac arrest: a mixed-methods study

Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial

scientific article

Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

scientific article published on 26 September 2011

Is the volume of mechanically ventilated admissions to UK critical care units associated with improved outcomes?

scientific article published on 7 February 2014

Maternal morbidity and mortality from severe sepsis: a national cohort study

scientific article

Novel models for the prediction of mortality after traumatic brain injury requiring intensive care.

scientific article published on 13 March 2008

Nurse staffing, medical staffing and mortality in Intensive Care: An observational study

scientific article published on 27 February 2014

Observational study of current use of selective decontamination of the digestive tract in UK critical care units

scientific article

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

scientific article published on 08 July 2020

OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients.

scientific article published on 07 May 2020

Outcome following admission to UK intensive care units after cardiac arrest: a secondary analysis of the ICNARC Case Mix Programme Database.

scientific article published in December 2007

Outcome prediction in critical care: the ICNARC model.

scientific article published on October 2008

Outcomes following oesophagectomy in patients with oesophageal cancer: a secondary analysis of the ICNARC Case Mix Programme Database.

scientific article published on January 2009

Outcomes of military patients treated at the UK Royal Centre for Defence Medicine 2007 to 2013.

scientific article published on 17 March 2014

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery

scientific article (published 2012-11-14)

Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial

scientific article published on June 2008

Predicting invasive fungal disease due to Candida species in non-neutropenic, critically ill, adult patients in United Kingdom critical care units. ⬇️

scientific article

Predicting mortality for patients with exacerbations of COPD and Asthma in the COPD and Asthma Outcome Study (CAOS).

scientific article published on 15 April 2009

Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients.

scientific article published on 29 March 2012

Prospective meta-analysis using individual patient data in intensive care medicine

scientific article published on 18 September 2009

Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU).

scientific article published on 14 December 2017

Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock

scientific article published in November 2015

Providing psychological support to people in intensive care: development and feasibility study of a nurse-led intervention to prevent acute stress and long-term morbidity

article

Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI): protocol for a cluster-randomised clinical trial of a complex intervention.

scientific article published on 8 February 2018

Psychological outcomes following a nurse-led preventative psychological intervention for critically ill patients trial: Statistical and health economic analysis plan

scientific article published on 29 January 2018

Psychometric assessment of the Family Satisfaction in the Intensive Care Unit questionnaire in the United Kingdom.

scientific article

Randomized Study of Early Continuous Positive Airways Pressure in Acute Respiratory Failure in Children With Impaired Immunity (SCARF) ISRCTN82853500

scientific article published on 01 October 2018

Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom*

article

Recognising and responding to acute illness in patients in hospital.

scientific article published on 29 November 2007

Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT

scientific article published in February 2021

Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).

scientific article

Regional variation in critical care provision and outcome after high-risk surgery

scientific article published on 23 July 2015

Relationship Between Peak Lactate and Patient Outcome Following High-Risk Gastrointestinal Surgery: Influence of the Nature of Their Surgery: Elective Versus Emergency.

scientific article

Relationship between height and outcomes among critically ill adults: a cohort study

scientific article published on 12 November 2018

Relationship between patients' outcomes and the changes in serum creatinine and urine output and RIFLE classification in a large critical care cohort database

scientific article

Reply from the authors. Reply: SDD and contextual effect

scientific article published in September 2015

Reproducibility of physiological track-and-trigger warning systems for identifying at-risk patients on the ward

scientific article published on 18 January 2007

Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT

scientific article published on 01 September 2018

Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial.

scientific article published on 7 August 2018

Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.

scientific article

Risk factors for invasive fungal disease in critically ill adult patients: a systematic review

scientific article

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people

scientific article published on 31 July 2020

Risk prediction models: recalibration

scientific article published on 01 January 2007

Risk-adjusted survival for adults following in-hospital cardiac arrest by day of week and time of day: observational cohort study

scientific article

Survival and quality of life for patients with COPD or asthma admitted to intensive care in a UK multicentre cohort: the COPD and Asthma Outcome Study (CAOS).

scientific article published on 13 October 2008

Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward

scientific article published on 22 February 2007

The Assessment of Risk in Cardiothoracic Intensive Care (ARCtIC): prediction of hospital mortality after admission to cardiothoracic critical care.

scientific article published on 26 September 2016

The CALORIES trial: statistical analysis plan.

scientific article published on December 2014

The Effect of ICU Out-of-Hours Admission on Mortality: A Systematic Review and Meta-Analysis.

scientific article

The Pancreatitis Outcome Prediction (POP) Score: A new prognostic index for patients with severe acute pancreatitis*

scientific article published on 01 July 2007

The Pancreatitis Outcome Prediction (POP) score: How about hematocrit and leukopenia?

scientific article published on 01 November 2007

The Protocolised Management in Sepsis (ProMISe) trial statistical analysis plan

scientific article published on December 2013

The Swine Flu Triage (SwiFT) study: development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic.

scientific article

The authors reply

The effect of postal questionnaire burden on response rate and answer patterns following admission to intensive care: a randomised controlled trial.

scientific article

The effect of secular trends and specialist neurocritical care on mortality for patients with intracerebral haemorrhage, myasthenia gravis and Guillain-Barré syndrome admitted to critical care : an analysis of the Intensive Care National Audit & Res

scientific article

The effects of critical care outreach services before and after critical care: a matched-cohort analysis

scientific article published on 01 June 2010

The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database

scientific article

The impact of the introduction of critical care outreach services in England: a multicentre interrupted time-series analysis.

scientific article published on January 2007

The impact of the organization of high-dependency care on acute hospital mortality and patient flow for critically ill patients

scientific article

The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database

scientific article published in April 2008

The organisation of critical care for burn patients in the UK: epidemiology and comparison of mortality prediction models

scientific article published on 15 May 2018

Trial of the route of early nutritional support in critically ill adults

scientific article published on October 2014

Use of selective gut decontamination in critically ill children: protocol for the Paediatric Intensive Care and Infection Control (PICnIC) pilot study

scientific article published on 11 March 2022

Using clinical databases to evaluate healthcare interventions

scientific article published on January 2010

Variation in critical care services across North America and Western Europe

scientific article

Why try to predict ICU outcomes?

scientific article

Winter excess mortality in intensive care in the UK: an analysis of outcome adjusted for patient case mix and unit workload

article

pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure

scientific article published in May 2017

qSOFA for Identifying Sepsis Among Patients With Infection.

scientific article published in January 2017

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