List of works - Thomas Calzascia

A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

scientific article published in Science

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

scientific article published on 26 April 2009

Aggravation of viral hepatitis by platelet-derived serotonin

scientific article published on 30 May 2008

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

scholarly article

Cutting edge: cross-presentation as a mechanism for efficient recruitment of tumor-specific CTL to the brain.

scientific article published in September 2003

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation

scientific article

Different Adaptations of IgG Effector Function in Human and Nonhuman Primates and Implications for Therapeutic Antibody Treatment ⬇️

scientific article published on March 28, 2012

Efficient induction of CD8 T-associated immune protection by vaccination with mRNA transfected dendritic cells

scientific article published on 01 October 2003

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

scientific article

Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a

scientific article

Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs.

scientific article published on February 2005

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

scientific article published on 03 February 2011

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

scientific article published in March 2008

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.

scientific article published on November 2016

Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo

scientific article

Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation.

scientific article

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

scientific article published on 19 December 2011

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity

scientific article published on 28 October 2019

Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis

scientific article published on 27 March 2013

Peripheral tolerance limits CNS accumulation of CD8 T cells specific for an antigen shared by tumor cells and normal astrocytes.

scientific article

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells

scientific article published on 24 October 2017

T-cell immune responses in the brain and their relevance for cerebral malignancies

scientific article published on 01 May 2003

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

scientific article

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

scientific article published on 21 December 2017

The brain parenchyma is permissive for full antitumor CTL effector function, even in the absence of CD4 T cells

scientific article published on 01 September 2000

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

scientific article

Vav1 GEF activity is required for T cell mediated allograft rejection

scientific article

List of works by Thomas Calzascia

A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

Aggravation of viral hepatitis by platelet-derived serotonin

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

Cutting edge: cross-presentation as a mechanism for efficient recruitment of tumor-specific CTL to the brain.

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation

Different Adaptations of IgG Effector Function in Human and Nonhuman Primates and Implications for Therapeutic Antibody Treatment ⬇️

Efficient induction of CD8 T-associated immune protection by vaccination with mRNA transfected dendritic cells

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a

Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs.

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.

Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo

Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation.

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity

Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis

Peripheral tolerance limits CNS accumulation of CD8 T cells specific for an antigen shared by tumor cells and normal astrocytes.

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells

T-cell immune responses in the brain and their relevance for cerebral malignancies

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

The brain parenchyma is permissive for full antitumor CTL effector function, even in the absence of CD4 T cells

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

Vav1 GEF activity is required for T cell mediated allograft rejection