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List of works by Rudolf Lucas

A FIM study to assess safety and exposure of inhaled single doses of AP301-A specific ENaC channel activator for the treatment of acute lung injury.

scientific article published on March 2014

A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

scientific article published on 30 August 2012

A computational study of the oligosaccharide binding sites in the lectin-like domain of Tumor Necrosis Factor and the TNF-derived TIP peptide

scientific article

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

scientific article

A role for TNF during African trypanosomiasis: involvement in parasite control, immunosuppression and pathology

scientific article

A role for lymphotoxin β receptor in host defense againstMycobacterium bovis BCG infection

scientific article published on 01 December 1999

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome.

scientific article published on 23 March 2018

AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na(+) current in primary dog, pig and rat alveolar type II cells

scientific article published on 9 January 2013

ATP-Depleting Carbohydrates Prevent Tumor Necrosis Factor Receptor 1-Dependent Apoptotic and Necrotic Liver Injury in Mice

scientific article published on 16 March 2007

Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling

scientific article

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

scientific article published on 23 January 2012

Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province

scientific article

Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases

scientific article published on 15 October 2010

An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes

scientific article published on 28 September 2009

An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain

scientific article published in January 2002

Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview

scientific article published on 22 September 2010

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

scientific article published on 07 August 2013

Arginase in the vascular endothelium: friend or foe?

scientific article published on 17 November 2014

Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells

scientific article published on 01 November 1998

C.1 TNF-like activity of Elsenia foetida coelomic fluid

CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells

scientific article

Caspase 9 gene polymorphism and susceptibility to lumbar disc disease in the Han population in northern China

scientific article published on 30 November 2010

Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure

scientific article

Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer

scientific article published on February 2006

Convergent evolution of cytokines

scientific article published in Nature

Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane‐bound TNF in experimental cerebral malaria ⬇️

scientific article published on July 1, 1997

Cytokine profiling of young overweight and obese female African American adults with prediabetes

scientific article

Cytokine-Ion Channel Interactions in Pulmonary Inflammation

scientific article published in January 2017

Dichotomal role of TNF in experimental pulmonary edema reabsorption

scientific article

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

scientific article

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations

scientific article (publication date: February 2010)

Diversity of killer cell immunoglobulin-like receptor genes in the Bai ethnic minority of Yunnan, China

scientific article

Ebselen improves ischemia-reperfusion injury after rat lung transplantation

scientific article published on 7 February 2009

Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites

scientific article published on December 2007

Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.

scientific article

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

scientific article

Essential structural features of TNF-α lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells

scientific article published on 27 October 2010

Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement

scientific article published on April 2010

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha

scientific article published on 3 July 2003

GM-CSF restores innate, but not adaptive, immune responses in glucocorticoid-immunosuppressed human blood in vitro

scientific article published in July 2003

Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population

scientific article

Glycosylation-dependent activation of epithelial sodium channel by solnatide

scientific article

HLA-B*15 subtypes distribution in Han population in Beijing, China, as compared with those of other populations

scientific article published on 14 March 2010

Harvesting, identification and barrier function of human lung microvascular endothelial cells

scientific article

Identification of a cytolytic protein in the coelomic fluid of Eisenia foetida earthworms

scientific article published on 01 February 1995

Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial

scientific article

Innovative cancer treatments that augment radiotherapy or chemo-therapy by the use of immunotherapy or gene therapy

scientific article published on June 2006

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China

scientific article published on 2 August 2010

Kupffer Cell-Expressed Membrane-Bound TNF Mediates Melphalan Hepatotoxicity via Activation of Both TNF Receptors

scientific article published on 01 September 2005

Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule

scientific article published on 01 February 2001

Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA.

scientific article published on 7 January 2014

Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells

scientific article published on 11 February 2018

Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes

scientific article

Mechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel

scientific article published on 27 September 2013

Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells

scientific article published on 01 October 1999

Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs

scientific article published on 15 July 2013

Modulation of soluble and membrane-bound TNF-induced phenotypic and functional changes of human brain microvascular endothelial cells by recombinant TNF binding protein I.

scientific article published in July 1997

Montelukast exerts no acute direct effect on NO synthases

scientific article published on 19 May 2006

Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei.

scientific article published on November 1993

Myeloid Pfkfb3 deficiency protects mice from hypoxia-induced pulmonary hypertension

scientific article published on 10 December 2020

Novel mechanisms of endothelial dysfunction in diabetes

scientific article published on April 2010

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.

scientific article published on 7 September 2017

Obesity-induced vascular inflammation involves elevated arginase activity

scientific article published on 23 August 2017

P2Y receptors as regulators of lung endothelial barrier integrity

scientific article published on January 2011

PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins

scientific article

Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans

scientific article

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes

scientific article

Population genetic analysis of 15 autosomal STR loci in the Russian population of northeastern Inner-Mongolia, China

scientific article

Potential of colony-stimulating factors to improve host defense in organ transplant recipients

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

scientific article

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

scientific article published on 10 January 2014

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

scientific article

Recent advances on the role of the endothelium in pulmonary function and disease

scientific article published on 19 July 2008

Redox control of hepatic cell death

scientific article published in April 2003

Regulation of NADPH oxidase 5 by protein kinase C isoforms

scientific article

Regulators of endothelial and epithelial barrier integrity and function in acute lung injury

scientific article published on 3 February 2009

Respective role of TNF receptors in the development of experimental cerebral malaria.

scientific article published in February 1997

Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants

scientific article published on 24 February 2017

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins

scientific article published on 22 December 2016

Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction

scientific article published on 4 May 2017

Role of ICAM-1 (CD54) in the development of murine cerebral malaria

scientific article

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

scientific article published on February 2016

Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise

scientific article published in November 2016

Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei.

scientific article

TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B

scientific article published on 29 May 2017

TNF: a moonlighting protein at the interface between cancer and infection

scientific article published on May 2008

Terbutaline improves ischemia-reperfusion injury after left-sided orthotopic rat lung transplantation

scientific article

The Dual Role of TNF in Pulmonary Edema

scientific article published on January 2010

The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit

scientific article published on 19 September 2016

The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug

The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti-TNF-alpha, but not by anti-IL-6 or anti-IFN-gamma antibodies.

scientific article

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition

scientific article published on 13 January 2010

The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation

scientific article published on March 2010

The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

scientific article published on 01 October 1999

The potential of GM-CSF to improve resistance against infections in organ transplantation

scientific article published on May 2004

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

scientific article published on 9 July 2013

Toxicity of nutritionally available selenium compounds in primary and transformed hepatocytes

scientific article published on September 2004

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

scientific article published on 27 May 2016

Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of tumor necrosis factor, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida foetida

scientific article published in January 2002

Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome

scientific article published in September 2002

Tumor necrosis factor: how to make a killer molecule tumor-specific?

scientific article

l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice

scientific article published on 24 December 2013

αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation.

scientific article

β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury

scientific article

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