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List of works by Marta Ruiz-Ortega

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

scientific article

3,4-DGE is cytotoxic and decreases HSP27/HSPB1 in podocytes.

scientific article published on 15 December 2013

3,4-Dideoxyglucosone-3-ene as a mediator of peritoneal demesothelization.

scientific article published on 3 June 2008

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury

scientific article

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells

scientific article

ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis

scientific article published on 01 December 1995

ACE inhibitors and AT(1) receptor antagonists-beyond the haemodynamic effect

scientific article published on 01 May 2000

Acute kidney injury transcriptomics unveils a relationship between inflammation and ageing

scientific article

Albumin-induced apoptosis of tubular cells is modulated by BASP1.

scientific article

Angiotensin II Moderately Decreases Plasmodium Infection and Experimental Cerebral Malaria in Mice

scientific article

Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation

scientific article published on 28 May 2008

Angiotensin II and Reactive Oxygen Species

scientific article published on 01 September 2005

Angiotensin II and renal fibrosis.

scientific article

Angiotensin II contributes to renal fibrosis independently of Notch pathway activation

scientific article

Angiotensin II increases connective tissue growth factor in the kidney.

scientific article published in November 2003

Angiotensin II increases parathyroid hormone-related protein (PTHrP) and the type 1 PTH/PTHrP receptor in the kidney

scientific article published on 01 June 2002

Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts ⬇️

scientific article published on December 1, 1997

Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney.

scientific article published in December 2002

Angiotensin II, the immune system and renal diseases: another road for RAS?

scientific article published on 01 August 2003

Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.

scientific article

Angiotensin II, via angiotensin receptor type 1/nuclear factor-κB activation, causes a synergistic effect on interleukin-1-β-induced inflammatory responses in cultured mesangial cells.

scientific article published on 29 October 2014

Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cells

scientific article published on 01 June 2000

Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria

scientific article published on 19 September 2016

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation

scientific journal article

Anti-inflammatory actions of quinapril

scientific article published on 03 April 2007

Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus

scientific article published on 04 January 2012

Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort.

scientific article published on 27 January 2015

Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress.

scientific article

Atrasentan for the treatment of diabetic nephropathy.

scientific article published on 4 May 2017

BASP1 promotes apoptosis in diabetic nephropathy.

scientific article

BET Proteins: An Approach to Future Therapies in Transplantation.

scientific article published on 7 February 2017

BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure.

scientific article

Biocompatibility Reduces Inflammation-Induced Apoptosis in Mesothelial Cells Exposed to Peritoneal Dialysis Fluid

scientific article published on 01 January 2015

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

scientific article

Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling.

scientific article published on 13 June 2016

Characterization of epithelial-to-mesenchymal transition of mesothelial cells in a mouse model of chronic peritoneal exposure to high glucose dialysate.

scientific article

Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

scientific article published on 21 November 2017

Connective tissue growth factor is a new ligand of epidermal growth factor receptor.

scientific article published on 8 August 2013

Corrigendum to "T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage".

scientific article published on 8 February 2017

Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?

scientific article published on 19 January 2020

Could Notch signaling pathway be a potential therapeutic option in renal diseases?

scientific article published on 10 February 2018

Designing drugs that combat kidney damage.

scientific article published on 03 April 2015

Effect of simultaneous blockade of AT1 and AT2 receptors on the NFkappaB pathway and renal inflammatory response.

scientific article published on October 2003

Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells.

scientific article

Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology

scientific article published on 13 December 2018

Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis

scientific article published on 01 April 2007

Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis

scientific article published on 01 December 1996

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.

scientific article published on 27 June 2016

Fn14 in podocytes and proteinuric kidney disease.

scientific article

Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.

scientific article

GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells.

scientific article

Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells

scientific article published on 01 January 2012

Gremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells.

scientific article published on 18 May 2014

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.

scientific article

Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy.

scientific article

HMG-CoA Reductase Inhibitors Decrease Angiotensin II–Induced Vascular Fibrosis

scientific article published on 25 June 2007

HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II

scientific journal article

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.

scientific article published on 12 January 2017

Histone lysine crotonylation during acute kidney injury in mice

scientific article published on 28 April 2016

Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade

scientific article (publication date: 2015)

IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis

scientific article published on 24 September 2020

IL-17A is a novel player in dialysis-induced peritoneal damage.

scientific article published on 19 February 2014

Inflammation and angiotensin II.

scientific article

Inflammatory and Fibrotic Mediators in Renal Diseases

scientific article published on 10 February 2019

Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.

scientific article

Inhibitory effect of interleukin-1β on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells

scientific article published on 07 November 2007

Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation.

scientific article published in July 2014

Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats

scientific article published on 01 March 2007

KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients.

scientific article

Long-term treatment with an ACE inhibitor or an AT1 antagonist avoids hypertension-induced inflammation in the kidney

scientific article published on 01 November 2006

Lyso-Gb3 activates Notch1 in human podocytes

scientific article published on 23 July 2015

Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H

scientific article published on 21 September 2010

Molecular mechanisms of angiotensin II-induced vascular injury.

scientific article

NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy

scientific article published on 27 July 2004

Obstructive renal injury: from fluid mechanics to molecular cell biology

scientific article published on 22 April 2010

Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine

scientific article

Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating factor stimulation ⬇️

scientific article published on April 1, 1998

Oxidative Stress in Disease and Aging: Mechanisms and Therapies

scientific article published on 10 December 2015

PPAR-γ agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage.

scientific article published on 7 June 2010

Parathyroid hormone-related protein promotes epithelial-mesenchymal transition

scientific article

Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter.

scientific article published on 9 January 2008

Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells.

scientific article

Paricalcitol reduces peritoneal fibrosis in mice through the activation of regulatory T cells and reduction in IL-17 production

scientific article

Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.

scientific article

Pharmacological modulation of peritoneal injury induced by dialysis fluids: is it an option?

scientific article published on 29 September 2011

Proinflammatory actions of angiotensins.

scientific article

Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells.

scientific article published on September 2005

Regulation of miR-29b and miR-30c by vitamin D receptor activators contributes to attenuate uraemia-induced cardiac fibrosis.

scientific article published on 28 April 2017

Renal and vascular hypertension-induced inflammation: role of angiotensin II.

scientific article

Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy

scientific article published on 01 October 2003

Renal expression of angiotensin type 2 (AT2) receptors during kidney damage.

scientific article published in October 2003

Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy.

scientific article

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

scientific article published on 23 December 2018

Role of Parathyroid Hormone-Related Protein in Tubulointerstitial Apoptosis and Fibrosis after Folic Acid-Induced Nephrotoxicity

scientific article published on 03 May 2006

Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II

scientific article published on 01 December 2006

Role of the renin-angiotensin system in vascular diseases: expanding the field.

scientific article

Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients

scientific article

Special Issue "Diabetic Nephropathy: Diagnosis, Prevention and Treatment"

scientific article published on 17 March 2020

Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.

scientific article published on 30 November 2010

Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells.

scientific article

Susceptibility to T cell-mediated injury in immune complex disease is linked to local activation of renin-angiotensin system: the role of NF-AT pathway

scientific article published on 01 October 2002

Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors

scientific article

T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage

scientific article

TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2.

scientific article published on 5 May 2015

TGF-beta signaling in vascular fibrosis.

scientific article published on 12 February 2007

TNF superfamily: a growing saga of kidney injury modulators.

scientific article

TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-κB pathway and ERK activation

scientific article published on July 2015

TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease

scientific article published on 06 July 2020

TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21

scientific article (publication date: 29 January 2010)

TWEAK and the kidney: the dual role of a multifunctional cytokine.

scientific article published on January 2011

TWEAK and the progression of renal disease: clinical translation

scientific article

TWEAK promotes peritoneal inflammation

scientific article

TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation.

scientific article

Taming apoptosis in peritoneal dialysis.

scientific article published on February 2009

Targeting inflammation in diabetic kidney disease: early clinical trials

scientific article

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

scientific article

Targeting the progression of chronic kidney disease

scientific article published on 14 February 2020

Tenofovir nephrotoxicity: 2011 update

scientific article published on 7 June 2011

The C-terminal module IV of connective tissue growth factor, through EGFR/Nox1 signaling, activates the NF-κB pathway and proinflammatory factors in vascular smooth muscle cells.

scientific article published on January 2015

The Rho-kinase pathway regulates angiotensin II-induced renal damage.

scientific article

The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification

scientific article published on 26 December 2020

Translational study of the Notch pathway in hypertensive nephropathy

scientific article published on 30 April 2014

Tubular overexpression of Gremlin in transgenic mice aggravates renal damage in diabetic nephropathy

scientific article published on 8 July 2015

Tubular overexpression of gremlin induces renal damage susceptibility in mice

scientific article

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease

scientific article published on January 2014

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia

scientific article published in May 2009

Unilateral ureteral obstruction: beyond obstruction.

scientific article published on 27 September 2013

Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin

scientific article published on 6 August 2015

[Animal models of peritoneal dialysis: relevance, difficulties, and future]

scientific article published on 01 January 2008

[TWEAK, the facilitator of acute kidney injury]

scientific article published on 01 January 2008

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