List of works - Roberto P Falcão

(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo.

scientific article

A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+ chronic myeloid leukemia

scientific article published on 31 December 2011

Acquired TERT promoter mutations stimulate TERT transcription in mantle cell lymphoma.

scientific article published on 6 February 2016

Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1.

scientific article published in January 2007

Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase

scientific article published on 01 October 2006

Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia

scientific article published in December 2007

An age-related gamma delta T cell suppressor activity correlates with the outcome of autoimmunity in experimental Trypanosoma cruzi infection.

scientific article

Antibody-dependent cellular cytotoxicity in chronic human Chagas disease

scientific article published on 01 July 1983

Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies ⬇️

scientific article published on December 18, 2010

Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells.

scientific article

Assessment of drug sensitivity of human leukaemic myeloblasts. II. The toxic effects of cytosine arabinoside on 125IUdR-labelled human leukaemic myeloblasts in mice ⬇️

scientific article published on September 1, 1977

Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model

scientific article published on 20 April 2006

Blastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity

scientific article published on 01 September 2002

Blastoid mantle cell lymphoma with t(2;8) (p12;q24)

scientific article published on 01 October 2007

CD10 and CD19 fluorescence intensity of B-cell precursors in normal and leukemic bone marrow. Clinical characterization of CD10(+strong) and CD10(+weak) common acute lymphoblastic leukemia

scientific article published on 01 May 1999

Cardiac stunning as a manifestation of ATRA differentiation syndrome in acute promyelocytic leukemia

scientific article published on 26 January 2011

Characterization of acute lymphoblastic leukemia subtypes in Brazilian patients

scientific article published on 01 April 1996

Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay

scientific article published on 01 January 2007

Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia

scientific article published on 29 April 2011

Comparative analysis of the pathological events involved in immune and non-immune TRALI models.

scientific article

Decreased activity of the multidrug resistance P‐glycoprotein in acquired aplastic anaemia: possible pathophysiologic implications ⬇️

scientific article published on September 1, 1998

Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia

scientific article published on 01 May 2008

Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.

scientific article published on 22 October 2012

Expression of CD117 and CD11b in bone marrow can differentiate acute promyelocytic leukemia from recovering benign myeloid proliferation

scientific article published on 01 July 2002

FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities.

scientific article

Fas-mediated apoptosis with normal expression of bcl-2 and p53 in lymphocytes from aplastic anaemia

scientific article published on 01 March 1998

Flow cytometry characterization of leukemic phase of nasal NK/T-cell lymphoma in tumor biopsies and peripheral blood

scientific article published on 01 February 2007

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

scientific article

Genetic mutations in patients with acute myeloid leukemia and leukostasis.

scientific article published on 23 March 2013

Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway

scientific article

Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.

scientific article published on 23 June 2015

Identification of a new translocation that disrupts the RUNX1 gene in a patient with de novo acute myeloid leukemia.

scientific article published on 6 March 2011

Incidence and risk factors for agranulocytosis in Latin American countries--the Latin Study: a multicenter study

scientific article published on 26 June 2008

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

scientific article published on September 2009

Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia.

scientific article published on 8 April 2013

Interaction of 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate with mimetic membranes and cytotoxic effect on leukemic cells.

scientific article

Lack of BCR/ABL rearrangement in acute and chronic T cell leukemias

scientific article published on 01 September 1997

Leu 7+, Leu 11a- acute T-lymphoblastic leukemia having low K cell activity and no NK cell activity

scientific article published on 01 January 1987

Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity

scientific article

MDR1 gene C3435T polymorphism and the risk of acquired aplastic anaemia

scientific article published on 01 June 2002

Malignant T gamma/delta lymphoproliferative disease with natural killer lytic activity

scientific article published on October 1, 1992

Mantle cell lymphoma harboring Burkitt's-like translocations presents differential expression of aurora kinase genes compared with others 8q abnormalities.

scientific article

Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. ⬇️

scientific article published on 19 April 2012

Microgranular and t(11;17)/PLZF-RARalpha variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13, CD34, and CD15 expression characteristic of PML-RARalpha gene rearrangement.

scientific article published in May 2004

Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia.

scientific article

Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases.

scientific article

Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis.

scientific article

Phenotypic and functional evaluation of natural killer cells in thymectomized children

scientific article published on 01 December 1996

SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL.

scientific article

Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype

scientific article published on 01 April 2010

Sézary syndrome with T/NK phenotype: A variant phenotype or a distinct clinical entity?

scientific article published on 28 October 2016

T-lymphocyte subpopulations in the peripheral blood and bone marrow of patients with aplastic anemia

scientific article published on 01 February 1985

Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A.

scientific article published on 13 April 2017

Tetrasomy 8 in a patient with chronic lymphocytic leukemia

scientific article published on 01 April 2010

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

scientific article

The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance.

scientific article published in February 2005

The effect of unmodified or prestorage white cell-reduced allogeneic red cell transfusions on the immune responsiveness in orthopedic surgery patients

scientific article published on 01 July 1999

The expression of DeltaNTP73, TATP73 and TP53 genes in acute myeloid leukaemia is associated with recurrent cytogenetic abnormalities and in vitro susceptibility to cytarabine cytotoxicity

scientific article published on 17 April 2008

The expression of PRAME in chronic lymphoproliferative disorders

scientific article published on 01 May 2003

The higher expression of alpha and beta isoforms of the human glucocorticoid receptor in leukemic B-progenitors compared to normal CD10+ BM cells does not correlate with methylprednisolone-induced apoptosis.

scientific article published in April 2004

The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia ⬇️

scientific article published on December 1, 2001

The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment.

scientific article published on 11 November 2008

Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia

scholarly article by Gil Cunha De Santis et al published 2011 in Journal of Clinical Apheresis

Thiopurine methyltransferase polymorphisms in a Brazilian population.

scientific article

Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia

scientific article published on 14 February 2008

p-Iodophenol-enhanced luminol chemiluminescent assay applied to discrimination between acute lymphoblastic and minimally differentiated acute myeloid (FAB-M0) or acute megakaryoblastic (FAB-M7) leukemias.

scientific article published in January 2004

List of works by Roberto P Falcão

(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo.

A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+ chronic myeloid leukemia

Acquired TERT promoter mutations stimulate TERT transcription in mantle cell lymphoma.

Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1.

Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase

Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia

An age-related gamma delta T cell suppressor activity correlates with the outcome of autoimmunity in experimental Trypanosoma cruzi infection.

Antibody-dependent cellular cytotoxicity in chronic human Chagas disease

Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies ⬇️

Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells.

Assessment of drug sensitivity of human leukaemic myeloblasts. II. The toxic effects of cytosine arabinoside on 125IUdR-labelled human leukaemic myeloblasts in mice ⬇️

Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model

Blastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity

Blastoid mantle cell lymphoma with t(2;8) (p12;q24)

CD10 and CD19 fluorescence intensity of B-cell precursors in normal and leukemic bone marrow. Clinical characterization of CD10(+strong) and CD10(+weak) common acute lymphoblastic leukemia

Cardiac stunning as a manifestation of ATRA differentiation syndrome in acute promyelocytic leukemia

Characterization of acute lymphoblastic leukemia subtypes in Brazilian patients

Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay

Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia

Comparative analysis of the pathological events involved in immune and non-immune TRALI models.

Decreased activity of the multidrug resistance P‐glycoprotein in acquired aplastic anaemia: possible pathophysiologic implications ⬇️

Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia

Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.

Expression of CD117 and CD11b in bone marrow can differentiate acute promyelocytic leukemia from recovering benign myeloid proliferation

FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities.

Fas-mediated apoptosis with normal expression of bcl-2 and p53 in lymphocytes from aplastic anaemia

Flow cytometry characterization of leukemic phase of nasal NK/T-cell lymphoma in tumor biopsies and peripheral blood

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

Genetic mutations in patients with acute myeloid leukemia and leukostasis.

Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway

Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.

Identification of a new translocation that disrupts the RUNX1 gene in a patient with de novo acute myeloid leukemia.

Incidence and risk factors for agranulocytosis in Latin American countries--the Latin Study: a multicenter study

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia.

Interaction of 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate with mimetic membranes and cytotoxic effect on leukemic cells.

Lack of BCR/ABL rearrangement in acute and chronic T cell leukemias

Leu 7+, Leu 11a- acute T-lymphoblastic leukemia having low K cell activity and no NK cell activity

Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity

MDR1 gene C3435T polymorphism and the risk of acquired aplastic anaemia

Malignant T gamma/delta lymphoproliferative disease with natural killer lytic activity

Mantle cell lymphoma harboring Burkitt's-like translocations presents differential expression of aurora kinase genes compared with others 8q abnormalities.

Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. ⬇️

Microgranular and t(11;17)/PLZF-RARalpha variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13, CD34, and CD15 expression characteristic of PML-RARalpha gene rearrangement.

Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia.

Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases.

Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis.

Phenotypic and functional evaluation of natural killer cells in thymectomized children

SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL.

Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype

Sézary syndrome with T/NK phenotype: A variant phenotype or a distinct clinical entity?

T-lymphocyte subpopulations in the peripheral blood and bone marrow of patients with aplastic anemia

Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A.

Tetrasomy 8 in a patient with chronic lymphocytic leukemia

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance.

The effect of unmodified or prestorage white cell-reduced allogeneic red cell transfusions on the immune responsiveness in orthopedic surgery patients

The expression of DeltaNTP73, TATP73 and TP53 genes in acute myeloid leukaemia is associated with recurrent cytogenetic abnormalities and in vitro susceptibility to cytarabine cytotoxicity

The expression of PRAME in chronic lymphoproliferative disorders

The higher expression of alpha and beta isoforms of the human glucocorticoid receptor in leukemic B-progenitors compared to normal CD10+ BM cells does not correlate with methylprednisolone-induced apoptosis.

The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia ⬇️

The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment.

Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia

Thiopurine methyltransferase polymorphisms in a Brazilian population.

Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia

p-Iodophenol-enhanced luminol chemiluminescent assay applied to discrimination between acute lymphoblastic and minimally differentiated acute myeloid (FAB-M0) or acute megakaryoblastic (FAB-M7) leukemias.