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List of works by Christophe Guignabert

A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents

scientific article published on 12 July 2012

A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population

scientific article published on 24 August 2017

ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad

scientific article published on 21 June 2018

Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

scientific article published on 11 July 2020

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

scientific article published on 06 January 2021

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension

scientific article published in May 2008

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

scientific article published on 19 March 2021

Angiomatoid fibrous histiocytoma of the pulmonary artery: a multidisciplinary discussion.

scientific article

Association Between BMI and Obesity With Survival in Pulmonary Arterial Hypertension

scientific article published on 22 May 2018

Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension

scientific article published on 29 October 2010

BMPR2 mutation status influences bronchial vascular changes in pulmonary arterial hypertension.

scientific article

Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension

scientific article published on 26 March 2009

CD74-Dependent Interleukin-6 And Monocyte Chemoattractant Protein-1 Secretion By Pulmonary Endothelial Cells In Idiopathic Pulmonary Hypertension

Cellular microparticles in the pathogenesis of pulmonary hypertension

scientific article published on 20 December 2012

Chronic inflammation within the vascular wall in pulmonary arterial hypertension: more than a spectator

scientific article published on 01 April 2020

Clinical pharmacology of endothelin receptor antagonists used in the treatment of pulmonary arterial hypertension.

scientific article

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease

scientific article published on 12 March 2020

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

scientific article published on 01 July 2014

Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.

scientific article published on 22 November 2017

Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans

scientific article

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

scientific article

Dasatinib increases endothelial permeability leading to pleural effusion

scientific article published on 18 January 2018

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension.

scientific article published on 02 August 2016

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.

scientific article published on 13 January 2016

Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies?

scientific article published on 17 August 2020

Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension

scientific article published on 10 March 2018

Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity

scientific article

Developmental expression of LC3α and β: Absence of fibronectin or autophagy phenotype in LC3β knockout mice

scientific article (publication date: 2007)

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

scientific article published on 13 August 2009

Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing

scientific journal article

Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension

scientific article published on 02 August 2012

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

article by Yuichi Tamura et al published 1 May 2018 in Journal of Clinical Investigation

Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction

scientific article published on 10 December 2018

Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension.

scientific article published on January 2013

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

scientific article published on 18 June 2020

Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents

scientific article published on 09 February 2009

Endothelin-1 receptor antagonists in fetal development and pulmonary arterial hypertension

scientific article

Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer.

scientific article published on 4 September 2013

Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension

scientific article published on 13 December 2018

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

scientific article published on 17 March 2013

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

scientific article published on 01 October 2019

Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay

scientific article published on March 2014

Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension

article by Nicolas Ricard et al published 15 April 2014 in Circulation

Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension

scientific article

Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease

scientific article

Key roles of Src family tyrosine kinases in the integrity of the pulmonary vascular bed.

scientific article

Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension

scientific article published on 23 February 2012

Leptin signalling system as a target for pulmonary arterial hypertension therapy

scientific article published on 05 March 2015

Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

scientific article published on 23 January 2020

Long-term outcomes of dasatinib-induced pulmonary arterial hypertension: a population-based study.

scientific article

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

scientific article published on 01 October 2018

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

scientific article published on 25 April 2020

Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study

scientific article published on 01 September 2019

Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis ⬇️

scientific article published on 18 December 2018

N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats

scientific article

Nasal decongestant exposure in patients with pulmonary arterial hypertension: a pilot study.

scientific article

Neurohormonal axis in patients with pulmonary arterial hypertension: friend or foe?

scientific article

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats

scientific article published on 01 March 2020

New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication

scientific article

New targets for pulmonary arterial hypertension: going beyond the currently targeted three pathways

scientific article published on 02 June 2017

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

article

Optimising experimental research in respiratory diseases: an ERS statement.

scientific article

P130Cas-Dependent Reversal Of Pulmonary Arterial Muscularization By Imatinib, Gefitinib And Dovitinib

PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis

scientific article published on 01 January 2019

Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension

scientific article published on 11 August 2017

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

scientific article published on December 2013

Pathology and Pathobiology of Pulmonary Hypertension

scientific article published on 15 October 2017

Pathology and pathobiology of pulmonary hypertension.

scientific article published on 13 September 2013

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

scientific article published on 24 January 2019

Precision medicine and personalising therapy in pulmonary hypertension: seeing the light from the dawn of a new era.

scientific article published on 13 April 2018

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

scientific article published on 29 September 2019

Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

scientific article

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

scientific article

Pulmonary Complications of Bcr-Abl Tyrosine Kinase Inhibitors

scientific article published on 11 June 2020

Pulmonary alveolar proteinosis revealing a telomerase disease

scientific article published in August 2013

Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance-pharmacodynamic study

scientific article published on 09 May 2019

Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy

scientific article published on 17 October 2013

Pulmonary arterial hypertension in patients treated by dasatinib

scientific article

Pulmonary arterial remodeling induced by a Th2 immune response

scientific article published on 28 January 2008

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy

scientific article published on 15 March 2018

Purinergic Dysfunction in Pulmonary Arterial Hypertension

scientific article published on 01 September 2020

Recurrence of pulmonary emphysema in an alpha-1 proteinase inhibitor-deficient lung transplant recipient.

scientific article

Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

scientific article published on 21 January 2016

Relevant issues in the pathology and pathobiology of pulmonary hypertension

scientific article published on December 2013

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

scientific article published on February 2017

Reply: The Renin–Angiotensin System in Pulmonary Hypertension

scientific article published on 15 May 2013

Response by Guignabert et al to Letter Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension"

scientific article published on 01 April 2019

Response to the article "Sorafenib as a potential strategy for refractory pulmonary arterial hypertension".

scientific article published on 4 April 2017

Restoring BMPRII functions in pulmonary arterial hypertension: opportunities, challenges and limitations.

scientific article published on 21 December 2016

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

scientific article published on 20 September 2013

Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets

scientific article published on 13 November 2018

Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

scientific article published in August 2015

Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis

scientific article published on 13 August 2017

S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4

scientific article

SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

scientific journal article

Screening for pulmonary arterial hypertension in adults carrying a <i>BMPR2</i> mutation

scientific article published on 30 December 2020

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

scientific article published on 01 March 2019

Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats ⬇️

scientific article published in May 2005

Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling

scientific article published on 13 December 2007

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.

scientific article published in June 2018

T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

scientific article published on 29 August 2018

Targeted therapies in pulmonary arterial hypertension

scientific article published on 14 October 2013

Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension

scientific article published on 13 August 2020

Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension.

scientific article published in October 2015

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

scientific article published on 08 June 2020

The Multiple Roles of Macrophage Migration Inhibitory Factor in Pulmonary Hypertension

scientific article published on 02 October 2019

The Thousand Faces of Leptin in the Lung

scientific article published on 11 August 2020

Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

scientific article published on 27 November 2018

Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.

scientific article published on 26 June 2013

Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

scientific article published on 02 October 2009

Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension ⬇️

scientific article published in 2006

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension

scientific article published on 20 September 2016

Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension

scientific article published on 7 December 2016

Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats.

scientific article published on 24 June 2016

Tyrosine kinase inhibitors in pulmonary arterial hypertension: a double-edge sword?

scientific article published on 13 September 2013

Update in Pulmonary Vascular Disease 2016 and 2017

scientific article published on 01 July 2018

Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell properties.

scientific article published in March 2006

[IL6R is the key therapeutical target in pulmonary arterial hypertension]

scientific article published on 01 October 2018

[New insights in the pathogenesis of pulmonary arterial hypertension]

scientific article published on 19 April 2019

[Pathophysiology of pulmonary hypertension: advances and prospects].

scientific article

[Relevant issues in the pathology and pathobiology of pulmonary hypertension].

scientific article published in October 2014

[Towards new targets for the treatment of pulmonary arterial hypertension : Importance of cell-cell communications].

scientific article

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