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List of works by Paul C Guest

A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology

scientific article published on 03 July 2013

Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia

scientific article published on January 2011

Algorithm development for diagnostic biomarker assays

scientific article published on January 2011

Alterations of stress related proteins in genetically altered mice revealed by two-dimensional differential in-gel electrophoresis analysis

scientific article

Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia.

scientific article published on 20 January 2011

Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selection

article

Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry

scientific article

Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS.

scientific article

Antipsychotic treatment of acute paranoid schizophrenia patients with olanzapine results in altered glycosylation of serum glycoproteins.

scientific article published on 29 May 2012

Application of Proteomic Techniques for Improved Stratification and Treatment of Schizophrenia Patients

scientific article

Application of meta-analysis methods for identifying proteomic expression level differences.

scientific article published on 6 June 2013

Applications of blood-based protein biomarker strategies in the study of psychiatric disorders

scientific article

Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders

scientific article

Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases

scientific article published on 30 April 2012

Blood test for schizophrenia ⬇️

scientific article published on August 26, 2012

Challenges in drug target discovery in bipolar disorder.

scientific article published on 18 February 2013

Challenges of introducing new biomarker products for neuropsychiatric disorders into the market

scientific article published on January 2011

Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses

scientific article

Characterization of the human serum depletome by label-free shotgun proteomics

scientific article published on 03 June 2011

Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry

scientific article published on 02 May 2011

Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometry.

scientific article published on 22 February 2012

Comparison of peripheral and central schizophrenia biomarker profiles

scientific article

Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome

scientific article published on 07 January 2011

Converging evidence of blood-based biomarkers for schizophrenia: an update

scientific article published on January 2011

Detection of gender differences in rat lens proteins using 2-D-DIGE.

scientific article published on January 2006

Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system

scientific article published in October 2013

Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders ⬇️

scientific article (publication date: 28 May 2013)

Differential phosphorylation of serum proteins reflecting inflammatory changes in schizophrenia patients

scientific article published on 15 December 2011

Distinct molecular phenotypes in male and female schizophrenia patients

scientific article

Distinct proteomic profiles in post-mortem pituitary glands from bipolar disorder and major depressive disorder patients

scientific article

Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules

scientific article

Effect of MK-801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes

scientific article

Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia

scientific article published on 27 March 2015

Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients.

scientific article published on 22 November 2012

Elevated S100B levels in schizophrenia are associated with insulin resistance

scientific article published on 01 January 2010

Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients

article

Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy

scientific article

Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia

scientific article published in September 2010

Identification of a biological signature for schizophrenia in serum

article

Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation

scientific article published on 22 September 2011

Identification of a molecular profile associated with immune status in first-onset schizophrenia patients.

scientific article published in January 2014

Identification of altered dipeptidyl-peptidase activities as potential biomarkers for unipolar depression

scientific article published on 31 July 2013

Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

scientific article published on 6 August 2013

Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients

scientific article

Identification of differentiating neural progenitor cell markers using shotgun isobaric tagging mass spectrometry

scientific article published in June 2006

Identification of early proteomic markers for hepatic steatosis

scientific article published on 01 August 2006

Identification of proteomic changes during differentiation of adult mouse subventricular zone progenitor cells.

scientific article published in February 2007

Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients ⬇️

scientific article published on March 13, 2012

Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways

scientific article

Identification of targeted analyte clusters for studies of schizophrenia

scientific article

Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients

scientific article published on 29 June 2010

Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders

scientific article

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia

scientific article published on 12 May 2015

Making Sense of Blood-Based Proteomics and Metabolomics in Psychiatric Research

scientific article

Metabolic, hormonal and stress-related molecular changes inpost-mortempituitary glands from schizophrenia subjects ⬇️

scientific article published on January 17, 2012

Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis

scientific article published on December 2009

Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue.

scientific article published on September 1993

Molecular sex differences in human serum

scientific article

Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission

scientific article published in June 2012

Multiplex Biomarker Approaches to Enable Point-of-Care Testing and Personalized Medicine

scientific article

Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3β signaling in bipolar patients

scientific article

Multiplex proteomic analysis by two-dimensional differential in-gel electrophoresis.

scientific article

Neuroimmune biomarkers in schizophrenia

scientific article

Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation

scientific article (publication date: 3 May 2002)

Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival.

scientific article

Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function

scientific article

Proinsulin processing in the diabetic Goto-Kakizaki rat

scientific journal article

Proteomic Approaches to Enable Point-of-Care Testing and Personalized Medicine for Psychiatric Disorders

scientific article

Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment.

scientific article published on 23 June 2006

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration

scientific article

Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

scientific article

Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission

scientific article published on 12 November 2012

Proteomic approaches to unravel the complexity of schizophrenia

scientific article published on January 2012

Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients

scientific article published on 5 June 2014

Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy.

scientific article

Proteomic enrichment analysis of psychotic and affective disorders reveals common signatures in presynaptic glutamatergic signaling and energy metabolism

scientific article

Proteomic profiling in schizophrenia: enabling stratification for more effective treatment

scientific article published on 26 March 2013

Proteomic technologies for biomarker studies in psychiatry: advances and needs

scientific article published on January 2011

Proteomics: improving biomarker translation to modern medicine?

scientific article published on 27 February 2013

Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies

scientific article published on 22 October 2012

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome

scientific article published on 27 January 2014

Sex Differences in Serum Markers of Major Depressive Disorder in the Netherlands Study of Depression and Anxiety (NESDA).

scientific article

Sex-specific serum biomarker patterns in adults with Asperger's syndrome.

scientific article

The Application of Multiplex Biomarker Techniques for Improved Stratification and Treatment of Schizophrenia Patients

scientific article

The Application of Multiplexed Assay Systems for Molecular Diagnostics

scientific article published on January 1, 2011

The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia

scientific article

The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.

scientific article

The need for a comprehensive molecular characterization of autism spectrum disorders

scientific article

The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics

scientific article published on 02 December 2010

The role of proteomics in depression research

scientific article

The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients

scientific article published on January 2014

To label or not to label: applications of quantitative proteomics in neuroscience research

scientific article published on 23 January 2012

Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders

scientific article

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