List of works - Tiziana Rubino

A molecular basis of analgesic tolerance to cannabinoids.

scientific article published on April 2007

Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models

scientific article

Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex

scientific article published on 2 October 2014

Adolescent exposure to cannabis as a risk factor for psychiatric disorders ⬇️

scientific article published on July 18, 2011

Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats

scientific article

Assay of GTPγS Binding in Autoradiography.

scientific article

Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.

scientific article

Binding of δ9-tetrahydrocannabinol and diazepam to human serum albumin

scientific article published on 9 May 2011

CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.

scientific article published on 6 July 2007

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism.

scientific article published on April 2005

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

scientific article (publication date: 2013)

Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine

scientific article published on 3 March 2010

Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.

scientific article

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

scientific article

Cannabis abuse in adolescence and the risk of psychosis: a brief review of the preclinical evidence.

scientific article

Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats

scientific article published on 7 February 2007

Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine

scientific article published in October 2004

Changes in rat spleen cannabinoid receptors after chronic CP-55,940: an autoradiographic study

scientific article published on 01 September 1997

Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940

scientific article published on 01 November 2000

Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade.

scientific article published in June 2006

Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism

scientific article published on 01 October 1993

Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors

scientific article published on 10 October 2016

Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats.

scientific article published on 17 September 2010

Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation

scientific article

Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.

scientific article published on 2 January 2008

Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions

scientific article published on 01 April 2000

Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain.

scientific article published on 12 March 2003

Chronic nandrolone decanoate exposure during adolescence affects emotional behavior and monoaminergic neurotransmission in adulthood

scientific article

Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring

scientific journal article

Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes.

scientific article published on 11 May 2006

Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats

scientific article

Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.

scientific article published in April 2004

ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure.

scientific article published in May 2006

Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.

scientific article published on June 1994

Endocannabinoids and Mental Disorders

scientific article published on January 2015

Endocannabinoids in the immune system and cancer.

scientific article published in February 2002

Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line.

scientific article published on 28 November 2005

Further investigations on the antipropulsive effect of centrally administered histamine and its relation with morphine ⬇️

scientific article published on January 21, 1992

Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats.

scientific article published on 29 November 2011

Immune function alterations in mice tolerant to delta9-tetrahydrocannabinol: functional and biochemical parameters

scientific article published on 01 December 1998

In vivo characterization of the specific cannabinoid receptor antagonist, SR141716A: behavioral and cellular responses after acute and chronic treatments

scientific article published on 01 January 2000

Influence of omega-conotoxin on morphine analgesia and withdrawal syndrome in rats

scientific article published on July 21, 1992

Intestinal effect of morphine 6-glucuronide: in vivo and in vitro characterization

scientific article published on 01 March 1994

Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward

scientific article

Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia

scientific article

Is cannabinoid transmission involved in rewarding properties of drugs of abuse?

scientific article published in August 2002

Lifelong imbalanced LA/ALA intake impairs emotional and cognitive behavior via changes in brain endocannabinoid system

scientific article

Long-lasting recovery of psychotic-like symptoms in isolation-reared rats after chronic but not acute treatment with the cannabinoid antagonist AM251

scientific article published on 06 October 2010

Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas

scientific article published on 24 December 2008

Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats.

scientific article

Loss of cannabinoid-stimulated guanosine 5'-O-(3-[(35)S]Thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats

scientific article published on 01 December 2000

Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect.

scientific article published in February 2013

Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment

scientific article published in March 2004

Molecular and cellular basis of cannabinoid and opioid interactions.

scientific article

Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems

scientific article

Morphine withdrawal syndrome and G protein expression: a study of the time course in the rat central nervous system.

scientific article published in November 1995

New vistas on cannabis use disorder

scientific article

Perinatal Δ9-Tetrahydrocannabinol Exposure Did Not Alter Dopamine Transporter and Tyrosine Hydroxylase mRNA Levels in Midbrain Dopaminergic Neurons of Adult Male and Female Rats ⬇️

scientific article published on September 1, 1998

Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently

scientific article published on 01 March 1991

Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism

scientific article published on 21 February 2011

Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.

scientific article published in May 2005

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

scientific article published on 20 June 2017

SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance ⬇️

scientific article published on January 8, 2012

Sex-dependent vulnerability to cannabis abuse in adolescence.

scientific article

Sexually dimorphic effects of cannabinoid compounds on emotion and cognition.

scientific article

The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models.

scientific article published on 07 August 2015

The anabolic steroid nandrolone alters cannabinoid self-administration and brain CB1 receptor density and function

scientific article published on 24 November 2016

The endocannabinoid system and psychiatric disorders

scientific article

The psychoactive ingredient of marijuana induces behavioural sensitization.

scientific article

Transcriptomic and proteomic analyses of mouse cerebellum reveals alterations in RasGRF1 expression following in vivo chronic treatment with delta 9-tetrahydrocannabinol.

scientific article

List of works by Tiziana Rubino

A molecular basis of analgesic tolerance to cannabinoids.

Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models

Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex

Adolescent exposure to cannabis as a risk factor for psychiatric disorders ⬇️

Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats

Assay of GTPγS Binding in Autoradiography.

Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.

Binding of δ9-tetrahydrocannabinol and diazepam to human serum albumin

CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism.

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine

Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

Cannabis abuse in adolescence and the risk of psychosis: a brief review of the preclinical evidence.

Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats

Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine

Changes in rat spleen cannabinoid receptors after chronic CP-55,940: an autoradiographic study

Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940

Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade.

Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism

Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors

Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats.

Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation

Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.

Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions

Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain.

Chronic nandrolone decanoate exposure during adolescence affects emotional behavior and monoaminergic neurotransmission in adulthood

Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring

Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes.

Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats

Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.

ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure.

Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.

Endocannabinoids and Mental Disorders

Endocannabinoids in the immune system and cancer.

Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line.

Further investigations on the antipropulsive effect of centrally administered histamine and its relation with morphine ⬇️

Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats.

Immune function alterations in mice tolerant to delta9-tetrahydrocannabinol: functional and biochemical parameters

In vivo characterization of the specific cannabinoid receptor antagonist, SR141716A: behavioral and cellular responses after acute and chronic treatments

Influence of omega-conotoxin on morphine analgesia and withdrawal syndrome in rats

Intestinal effect of morphine 6-glucuronide: in vivo and in vitro characterization

Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward

Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia

Is cannabinoid transmission involved in rewarding properties of drugs of abuse?

Lifelong imbalanced LA/ALA intake impairs emotional and cognitive behavior via changes in brain endocannabinoid system

Long-lasting recovery of psychotic-like symptoms in isolation-reared rats after chronic but not acute treatment with the cannabinoid antagonist AM251

Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas

Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats.

Loss of cannabinoid-stimulated guanosine 5'-O-(3-[(35)S]Thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats

Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect.

Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment

Molecular and cellular basis of cannabinoid and opioid interactions.

Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems

Morphine withdrawal syndrome and G protein expression: a study of the time course in the rat central nervous system.

New vistas on cannabis use disorder

Perinatal Δ9-Tetrahydrocannabinol Exposure Did Not Alter Dopamine Transporter and Tyrosine Hydroxylase mRNA Levels in Midbrain Dopaminergic Neurons of Adult Male and Female Rats ⬇️

Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently

Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism

Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance ⬇️

Sex-dependent vulnerability to cannabis abuse in adolescence.

Sexually dimorphic effects of cannabinoid compounds on emotion and cognition.

The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models.

The anabolic steroid nandrolone alters cannabinoid self-administration and brain CB1 receptor density and function

The endocannabinoid system and psychiatric disorders

The psychoactive ingredient of marijuana induces behavioural sensitization.

Transcriptomic and proteomic analyses of mouse cerebellum reveals alterations in RasGRF1 expression following in vivo chronic treatment with delta 9-tetrahydrocannabinol.