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Authors whose works are in public domain in at least one jurisdiction

List of works by Kristiina M Huttunen

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

scientific article published on 8 October 2014

Amino acids as promoieties in prodrug design and development ⬇️

scientific article published on October 22, 2012

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

scientific article published on 13 November 2019

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

scientific article published on 01 June 2013

Cytochrome P450-activated prodrugs: targeted drug delivery.

scientific article published on January 2008

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

scientific article published in October 2013

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome p450-activated prodrugs.

scientific article published on 31 August 2012

Diarylthiophenes as inhibitors of the pore-forming protein perforin

scientific article published on 7 December 2015

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

scientific article

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and <i>In Vitro</i> Evaluation of the Entire Positional Isomer Library of <i>ortho</i>-Carboranylmethyl-Bearing Glucoconjugates

scientific article published on 01 December 2020

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

scientific article published on 16 September 2014

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

scientific article published on 13 May 2020

Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen

scientific article published on 11 September 2018

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

scientific article published on 30 May 2012

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

scientific article published on 18 May 2011

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones ⬇️

scientific article published on December 22, 2011

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

scientific article published on 06 September 2019

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

scientific article published on 23 November 2020

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

scientific article published on 11 April 2020

Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

scientific article published on 18 June 2019

Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality

scientific article published on 15 February 2007

Prodrugs - an efficient way to breach delivery and targeting barriers.

scientific article published on January 2011

Prodrugs--from serendipity to rational design.

scientific article

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

scientific article published on 9 September 2014

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug

scientific article published on 18 July 2018

Sulfenamide and Sulfonamide Derivatives of Metformin - A New Option to Improve Endothelial Function and Plasma Haemostasis

scientific article published on 25 April 2019

Sulfenamide and sulfonamide derivatives of metformin can exert anti-coagulant and pro-fibrinolytic properties

scientific article published on 16 February 2018

Sustained release of metformin via red blood cell accumulated sulfenamide prodrug

scientific article published on 2 June 2014

Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE).

scientific article published on 5 January 2006

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

scientific article published on 05 August 2020

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

scientific article

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

scientific article published on 26 August 2014

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