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List of works by Patrick van der Wel

Amyloid-like fibrils from a domain-swapping protein feature a parallel, in-register conformation without native-like interactions.

scientific article

Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

scientific article published on 13 December 2016

Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH.

scientific article

Combined experimental/theoretical refinement of indole ring geometry using deuterium magnetic resonance and ab initio calculations.

scientific article published in October 2003

Complexes obtained by electrophilic attack on a dinitrogen-derived terminal molybdenum nitride: electronic structure analysis by solid state CP/MAS 15N NMR in combination with DFT calculations

Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington's disease

scientific article published on 15 June 2019

D-polyglutamine amyloid recruits L-polyglutamine monomers and kills cells.

scientific article published on 28 November 2013

Domain swapping and amyloid fibril conformation.

scientific article published on July 2012

Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.

scientific article

Energetics Underlying Twist Polymorphisms in Amyloid Fibrils

scientific article published on 19 December 2017

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

scientific article

Hidden motions and motion-induced invisibility: Dynamics-based spectral editing in solid-state NMR.

scientific article

High-Field Dynamic Nuclear Polarization for Solid and Solution Biological NMR

scientific article

High-resolution solid-state NMR structure of alanyl-prolyl-glycine.

scientific article

How amyloid precursor protein protects itself from cleavage.

scientific article

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core

scientific article published on February 2016

Hydrophobic mismatch between helices and lipid bilayers.

scientific article

In support of the BMRB.

scientific article published in September 2012

Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.

scientific article published on 4 October 2017

Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides.

scientific article published in June 2002

Lipid dynamics and protein-lipid interactions in 2D crystals formed with the β-barrel integral membrane protein VDAC1.

scientific article

MAS (1)H NMR Probes Freezing Point Depression of Water and Liquid-Gel Phase Transitions in Liposomes

scientific article

Methionine oxidized apolipoprotein A-I at the crossroads of HDL biogenesis and amyloid formation.

scientific article published on 17 January 2018

Multipole-multimode Floquet theory of rotational resonance width experiments: 13C-13C distance measurements in uniformly labeled solids

article

New applications of solid-state NMR in structural biology

scientific article published on 23 February 2018

Observation of a low-temperature, dynamically driven structural transition in a polypeptide by solid-state NMR spectroscopy.

scientific article published on January 2009

On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR.

scientific article published on 22 February 2017

Optimized aminolysis conditions for cleavage of N-protected hydrophobic peptides from solid-phase resins.

scientific article published in June 2001

Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptides.

scientific article published on 27 May 2007

Peptide-Directed Assembly of Single-Helical Gold Nanoparticle Superstructures Exhibiting Intense Chiroptical Activity

scientific article published on 11 October 2016

Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.

scientific article

Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

scientific article published on 11 February 2021

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

scientific article published on 18 September 2012

Solid-state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p.

scientific article

Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance

scientific article published on 26 October 2018

Structural changes and proapoptotic peroxidase activity of cardiolipin-bound mitochondrial cytochrome c

journal article published in 2015

Structural characterization of the caveolin scaffolding domain in association with cholesterol-rich membranes.

scientific article published on 13 December 2011

Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics

scientific article published on 14 March 2019

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils ⬇️

scientific article published on March 7, 2011

Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR.

scientific article

Tryptophan-Anchored Transmembrane Peptides Promote Formation of Nonlamellar Phases in Phosphatidylethanolamine Model Membranes in a Mismatch-Dependent Manner†

article

β-hairpin-mediated nucleation of polyglutamine amyloid formation.

scientific article published on 23 January 2013

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