List of works - Sarah F Hamm-Alvarez

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye

scientific article published on 15 April 2020

A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland

scientific article

A Tunable and Reversible Platform for the Intracellular Formation of Genetically Engineered Protein Microdomains ⬇️

scientific article published on October 25, 2012

A thermo-responsive protein treatment for dry eyes

scientific article

Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation.

scientific article published in January 2005

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells

scientific article

Actin microfilaments et al.—the many components, effectors and regulators of epithelial cell endocytosis ⬇️

scientific article published on November 14, 2003

Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland.

scientific article published in June 2004

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland

scientific article published on 02 April 2009

Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation.

scientific article

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure

scientific article published on 16 July 2010

Analyzing live cellularity in the human trabecular meshwork

scientific article

Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium

scientific article published on 26 August 2020

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2018

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

scientific article published on 30 August 2011

Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity.

scientific article

Current status of gene delivery and gene therapy in lacrimal gland using viral vectors.

scientific article published on 15 September 2006

Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome

scientific article published on 02 March 2017

Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain.

scientific article

Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site

scientific article

Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.

scientific article

Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra.

scientific article

Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini

scientific article

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines.

scientific article

Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains.

scientific article

Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton.

scientific article

Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate

scientific article

Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome

scientific article

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients

scientific article published on 23 July 2018

Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome

scientific article published on 17 July 2007

Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse

scientific article

Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function.

scientific article published on August 1999

Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome

scientific article published on 02 July 2019

Integrin adhesion in regulation of lacrimal gland acinar cell secretion

scientific article published on 24 April 2006

Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome

scientific article published on 13 September 2017

Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome

scientific article published on 27 December 2020

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

scientific journal article

Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome

scientific article published on 12 September 2018

Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy

scientific article

Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development.

scientific article

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles

scientific article

Microtubule-based motor proteins: new targets for enhancing drug delivery?

scientific article published on April 1996

Mitochondrial medicine and mitochondrion-based therapeutics☆

scientific article published on 17 July 2008

Modulation of secretory functions in epithelia by adenovirus capsid proteins.

scientific article published on December 2003

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1) ⬇️

scientific article published on September 8, 1998

Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide

scientific article published on 23 August 2019

Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis.

scientific article

Molecular motors and their role in membrane traffic.

scientific article

Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models.

scientific article published on 2 July 2018

NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis

scientific article published on 08 September 2018

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms

scientific article

Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression.

scientific article published in February 2001

Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini

scientific article

Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability

scientific article published on May 2007

PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease

scientific article published on 01 July 2019

Paclitaxel and nocodazole differentially alter endocytosis in cultured cells

scientific article published on 01 November 1996

Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells.

scientific article published on 19 April 2013

Quantitative second harmonic generation imaging of cartilage damage

scientific article published on 23 April 2008

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

scientific article

Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome.

scientific article published on January 2017

Site-specific labeling of enveloped viruses with quantum dots for single virus tracking

scientific article published on August 2008

Stable transfection of MDCK cells with epitope-tagged human PepT1.

scientific article

Targeting endocytosis and motor proteins to enhance DNA persistence.

scientific article

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances ⬇️

scientific article published on September 29, 2012

Tear cathepsin S as a candidate biomarker for Sjögren's syndrome

scientific article

Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland

scientific article published on 16 December 2014

The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway.

scientific article

The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini

scientific article published on 23 April 2008

Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells.

scientific article

Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol

scientific article

Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer.

scientific article published on May 2006

Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.

scientific article published on 24 October 2007

Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice.

scientific article published on January 2006

Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells ⬇️

scientific article published on December 3, 2011

List of works by Sarah F Hamm-Alvarez

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye

A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland

A Tunable and Reversible Platform for the Intracellular Formation of Genetically Engineered Protein Microdomains ⬇️

A thermo-responsive protein treatment for dry eyes

Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation.

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells

Actin microfilaments et al.—the many components, effectors and regulators of epithelial cell endocytosis ⬇️

Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland.

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland

Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation.

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure

Analyzing live cellularity in the human trabecular meshwork

Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells ⬇️

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity.

Current status of gene delivery and gene therapy in lacrimal gland using viral vectors.

Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome

Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain.

Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site

Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.

Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra.

Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines.

Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains.

Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton.

Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate

Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients

Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome

Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse

Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function.

Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome

Integrin adhesion in regulation of lacrimal gland acinar cell secretion

Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome

Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome

Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy

Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development.

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles

Microtubule-based motor proteins: new targets for enhancing drug delivery?

Mitochondrial medicine and mitochondrion-based therapeutics☆

Modulation of secretory functions in epithelia by adenovirus capsid proteins.

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1) ⬇️

Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide

Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis.

Molecular motors and their role in membrane traffic.

Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models.

NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms

Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression.

Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini

Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability

PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease

Paclitaxel and nocodazole differentially alter endocytosis in cultured cells

Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells.

Quantitative second harmonic generation imaging of cartilage damage

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome.

Site-specific labeling of enveloped viruses with quantum dots for single virus tracking

Stable transfection of MDCK cells with epitope-tagged human PepT1.

Targeting endocytosis and motor proteins to enhance DNA persistence.

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances ⬇️

Tear cathepsin S as a candidate biomarker for Sjögren's syndrome

Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland

The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway.

The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini

Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells.

Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol

Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer.

Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.

Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice.

Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells ⬇️