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List of works by Hans J. Gaus

Alternative approaches to infrared multiphoton dissociation in an external ion reservoir.

scientific article

Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis

scientific article published on 01 April 2009

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA ⬇️

scientific article published on October 27, 2010

Analysis of double-stranded oligonucleotides by electrospray mass spectrometry

scientific article published on 01 November 1994

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer

scientific article published on 01 March 1997

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

scientific article

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

scientific article

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides

scientific article published on 08 November 2010

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes

scientific article

Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100.

scientific article published on 15 December 2006

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides

scientific article published on 26 May 2015

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

scientific article published on 10 May 2016

Formation of 4,4'-dimethoxytrityl-C-phosphonate oligonucleotides.

scientific article

Formation of oligonucleotide adducts in pharmaceutical formulations

scientific article

Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

scientific article published on 18 June 2014

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration

scientific article published on 01 August 2001

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

scientific article

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

scientific article published in March 2006

In vitro metabolic stabilities and metabolism of 2'-O-(methoxyethyl) partially modified phosphorothioate antisense oligonucleotides in preincubated rat or human whole liver homogenates.

scientific article

Negative ionization micro electrospray mass spectrometry of oligonucleotides and their complexes

scientific article published on 01 January 1996

Optimization of capillary electrophoresis of mixtures of basic peptides and comparison with HPLC

scientific article published on 01 May 1993

Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue

scientific article

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.

scientific article

Preparation of oligonucleotides without aldehyde abasic sites

scientific article published on 01 July 2001

Separation of cardiac glycosides by micellar electrokinetic capillary electrophoresis

scientific article published in April 1993

Single-stranded siRNAs activate RNAi in animals

scientific article published on 01 August 2012

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry

scientific article published on 08 August 2015

Solution stability and degradation pathway of deoxyribonucleoside phosphoramidites in acetonitrile

scientific article

Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor.

scientific article

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

scientific article published on March 2010

Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs

scientific article published on 9 July 2004

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance

scientific article published in November 2003

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides ⬇️

scientific article published on September 22, 2011

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

scientific article

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.

scientific article published on 3 July 2014

Trichloroacetaldehyde modified oligonucleotides.

scientific article published in September 2005

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

scientific article published on May 2012

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