List of works by Lars Sävendahl

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

scientific article published on 27 February 2019

Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment

scientific article published on 19 March 2012

Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered.

scientific article

Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats

scientific article published on 23 August 2004

Androgen receptor modulation does not affect longitudinal growth of cultured fetal rat metatarsal bones.

scientific article

Animal models to explore the effects of glucocorticoids on skeletal growth and structure

scientific article published on 19 October 2017

Apoptosis is developmentally regulated in rat growth plate

scientific article published on 01 August 2002

Bidirectional relationship between eating disorders and autoimmune diseases

scientific article published on 03 September 2018

Body Fat Content Can Be Predicted In Vivo in Mice Using a Modified Dual-Energy X-Ray Absorptiometry Technique

scientific article published on 01 November 2001

Bortezomib and bone health in adults: can we extend these findings to children?

scientific article published on 22 March 2013

Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice

scientific article

Bortezomib treatment causes long-term testicular dysfunction in young male mice

scientific article

Bridging the gap: metabolic and endocrine care of patients during transition

scientific article

Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study

scientific article published on 10 February 2017

Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones

scientific article published on 8 October 2009

Cell volume and shape oscillations in rat type-II somatotrophs at hypotonic conditions

scientific article published on 01 May 1995

Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia

scientific article published on 01 July 2019

Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats

scientific article published on 22 September 2014

Common DNA variants predict tall stature in Europeans

scientific article published on 20 November 2013

Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large obse

scientific article

Delayed diagnoses of Turner's syndrome: proposed guidelines for change.

scientific article

Demonstration of Estrogen Receptor-β Immunoreactivity in Human Growth Plate Cartilage

scientific article published on 01 January 1999

Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone

scientific article

Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid.

scientific article

Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway

scientific article

Disproportional Body Growth in Female Estrogen Receptor-α-Inactivated Mice

scientific article published on 01 November 1999

Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation

scientific article published on 16 January 2008

Effects of galanin on growth hormone release in isolated cultured rat somatotrophs

scientific article published on September 1, 1993

Efficacy and Safety of Percutaneous Epiphysiodesis Operation around the Knee to Reduce Adult Height in Extremely Tall Adolescent Girls and Boys

scientific article

Epiphyseal fusion in the human growth plate does not involve classical apoptosis.

scientific article published in December 2009

Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate

scientific article published on 01 June 2002

Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice.

scientific article published in January 2004

Estrogen signaling in growth plate cartilage

scientific article published on 22 August 2011

Estrogens and growth: review.

scientific article published on June 2007

Etanercept treatment improves longitudinal growth in prepubertal children with juvenile idiopathic arthritis

scientific article published on 15 November 2007

Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development

scientific article (publication date: August 2002)

Expression of the aryl hydrocarbon receptor in growth plate cartilage and the impact of its local modulation on longitudinal bone growth

scientific article published on 10 April 2015

Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development

scientific article

Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans.

scientific article

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults

scientific article

GPR30 Estrogen Receptor Expression in the Growth Plate Declines as Puberty Progresses

scientific article published on 18 September 2007

Gender influences short-term growth hormone treatment response in children

scientific article published on 12 April 2012

Genes of importance in the hormonal regulation of growth plate cartilage

scientific article published on 29 April 2009

Genetic regulation of the growth plate

scientific article

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

scientific article

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

scientific article published on 8 January 2016

Glucocorticoid eye drops inhibit growth in the newborn rabbit

scientific article published in August 2005

Growth failure in early life: an important manifestation of Turner syndrome

scientific article published on 01 January 2002

Growth hormone and treatment outcomes: expert review of current clinical practice

scientific article published on December 2011

Growth hormone deficiency impairs blood clotting and reduces factor VII coagulant activity in rat

scientific article published on 01 April 1995

Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes

scientific article published on 01 March 2003

High prevalence of pituitary hormone deficiency in both unilateral and bilateral optic nerve hypoplasia

scientific article published on 05 March 2019

Highlights from the Second European Workshop on Growth Plate Research 2010

scientific article published on 01 December 2010

Hormonal regulation of growth plate cartilage

scientific article published on 01 January 2005

Hormones and genes of importance in bone physiology and their influence on bone mineralization and growth in Turner syndrome

scientific article published on 03 March 2010

Hypercalcemia in children

scientific article published on March 2008

Identification of a clonally expanding haematopoietic compartment in bone marrow

scientific article published on 27 November 2012

Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway

scientific article published on 01 January 2011

Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones

scientific journal article

Interleukin-6 acts locally on the growth plate to impair bone growth

scientific article published on 17 July 2013

Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-up

scientific article published on 18 December 2007

Intravenous pamidronate treatment improves growth in prepubertal osteogenesis imperfecta patients

scientific article published on 07 February 2011

Is safety of childhood growth hormone therapy related to dose? Data from a large observational study

scientific article

Is safety of childhood growth hormone therapy related to dose? Data from a large observational study

scientific article published on 01 March 2017

Lack of evidence for acute effects of growth hormone-releasing hormone on serum insulin and glucose levels in normal and hypophysectomized rats.

scientific article

Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages

scientific article published on 01 May 2003

Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis.

scientific article published on February 2006

Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study

scientific article published on 11 January 2012

Mechanisms of growth plate maturation and epiphyseal fusion

scientific article published on 04 May 2011

Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland

scientific article

Metacarpophalangeal Pattern Profile Analysis: Useful Diagnostic Tool for Differentiating between Dyschondrosteosis, Turner Syndrome, and Hypochondroplasia

journal article; published in Acta Radiologica in 2006

Metacarpophalangeal pattern profile analysis as a tool for early diagnosis of Turner syndrome.

scientific article published in July 2005

Mortality Is Not Increased in Recombinant Human Growth Hormone-treated Patients When Adjusting for Birth Characteristics

scientific article published on 26 February 2016

Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis

scientific article

Oestrogen receptors and linear bone growth

scientific article published on September 2007

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

scientific article

Pro-Inflammatory Cytokines Produced by Growth Plate Chondrocytes May Act Locally to Modulate Longitudinal Bone Growth

scientific article published on 12 April 2012

Proinsulin C-peptide regulates ribosomal RNA expression

scientific article

Proinsulin C-peptide regulates ribosomal RNA expression.

scientific article published in March 2017

Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction.

scientific article published in September 1997

Promoting growth in chronic inflammatory disease: lessons from studies of the growth plate

scientific article

Proteasome inhibition therapies in childhood cancer.

scientific article published in November 2007

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice

scientific article published in October 2007

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

scientific article published on March 2014

Raloxifene acts as an estrogen agonist on the rabbit growth plate

scientific article published in April 2003

Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth

scientific article

Reduced bone mineral density and radial bone growth in young rabbits treated with dexamethasone eye drops

scientific article

Regulation of bone growth via ligand-specific activation of estrogen receptor alpha

scientific article published on 20 December 2016

Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits

scientific article

Risk of Meningioma in European Patients Treated With Growth Hormone in Childhood: Results From the SAGhE Cohort

article published in 2019

Risks of malignant and non-malignant tumours in tall women treated with high-dose oestrogen during adolescence

scientific article published on 11 June 2014

Short Stature in KBG Syndrome: First Responses to Growth Hormone Treatment.

scientific article published on April 2015

Short and tall stature: a new paradigm emerges

scientific article

Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: A randomized dose-escalation trial

scientific article published on 28 June 2017

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats

scientific article

Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones

scientific article published on 9 January 2007

The 4th European Growth Plate Working Group Symposium (EUROGROP). 10th September 2004, Basel, Switzerland

article

The 7th ESPE Growth Plate Working Group symposium--EUROGROP, June 27th 2007, Helsinki, Finland

scientific article published in March 2008

The Evaluation and Management of Tall Stature

scientific article published on 5 February 2016

The Fifth European Growth Plate Working Group Symposium. 21st September 2005, Lyon, France

scientific article published in February 2006

The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therap

scientific article published on 26 April 2013

The Physiology of Childhood Growth: Hormonal Regulation

scientific article

The Sixth ESPE Growth Plate Working Group Symposium (EUROGROP), June 30th, Rotterdam, the Netherlands, "a multidisciplinary approach to growth plate biology"

scientific article published on 01 December 2006

The Third European Growth Plate Working Group Symposium. 17th September 2003, Ljubljana, Slovenia

scientific article published in April 2004

The biologics anakinra and etanercept prevent cytokine-induced growth retardation in cultured fetal rat metatarsal bones

scientific article published on 27 September 2011

The effect of acute and chronic stress on growth

scientific article published on 23 October 2012

The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone

scholarly article by Terhi J Heino et al published 29 February 2008 in Journal of Endocrinology

The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth

scientific article published on 18 June 2010

The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice

scientific article

The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice

scientific article

The use of bone age in clinical practice - part 1.

scientific article published on 21 June 2011

Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program

scientific article published on 01 October 2019

Turner syndrome: a pattern of early growth failure

scientific article published on 01 December 1999

Validation and reference values of automated bone age determination for four ethnicities

scientific article published on 6 August 2010

Venetoclax in cancer therapy and potential effects on bone

scientific article published on 01 August 2016

Vitamin D deficiency during pregnancy--potential threat to the child

scientific article published on 14 January 2011

Vitamin D levels in children born to vitamin D-deficient mothers

scientific article

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