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List of works by Alain R Baulard

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

scientific article published on 25 January 2016

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation

scientific article published on 10 May 2019

Activation of the pro-drug ethionamide is regulated in mycobacteria

scientific journal article

Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis.

scientific article published in January 2007

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.

scientific article published on 15 November 2017

Chemical Force Microscopy of Single Live Cells

scientific article published on 13 September 2007

Cloning, expression, and purification of the 27 kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis

scientific article published in July 2004

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

scientific article

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs

scientific article published on 15 May 2017

Direct Measurement of Hydrophobic Forces on Cell Surfaces Using AFM

scientific article published on 17 October 2007

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

scientific article

Doping in the peloton of antituberculosis drugs

scientific article published in April 2005

Effects of mechanical wounding on Carica papaya cysteine endopeptidases accumulation and activity

scientific article published on 03 April 2006

Ethambutol-induced alterations in Mycobacterium bovis BCG imaged by atomic force microscopy

scientific article published in November 2006

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

scientific article

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors

scientific article published on April 2011

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator

scientific article

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

scientific article

Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis

scientific journal article

In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system

scientific article published on 8 November 2002

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria

scientific article published on 24 March 2003

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis

scientific article

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

scientific article

MALDI imaging techniques dedicated to drug-distribution studies

scientific article

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis

scientific article published on 23 February 2009

Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR.

scientific article published in June 2005

New active leads for tuberculosis booster drugs by structure-based drug discovery

scientific article published on 28 November 2017

Organization of the mycobacterial cell wall: a nanoscale view

scientific article published on 28 November 2007

Phenotypic assays for Mycobacterium tuberculosis infection

scientific article published on 19 May 2017

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis

scientific journal article

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.

scientific article

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

scientific article

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection

scientific article published on 7 July 2016

Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria

scientific article published on 8 August 2006

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

scientific article

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

scientific article published on 14 April 2017

Structural and docking studies of potent ethionamide boosters

scientific article published on 24 October 2013

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis

scientific article published in October 2004

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

scientific article

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

scientific article published on 22 March 2014

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

scientific article published on 18 June 2015

Tuberculosis: the drug development pipeline at a glance

scientific article published on 25 February 2012

Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands

scientific article published on 20 February 2014

Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis

scientific article (publication date: 26 December 2003)

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