List of works - Michael Parker

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

scientific article

Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors

Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

scientific article

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

scientific article published on October 1999

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy

scholarly article by Tianbao Lu published in July 2018

Designing a diverse high-quality library for crystallography-based FBDD screening

scientific article

Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes

article published in 1998

Herpes simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis

scientific article published on 05 November 2020

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads

scientific article published on 30 March 2010

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-terminal tripeptide of the vaccinia D4 processivity factor

scientific article

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

scientific article

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)

scientific article

Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family

scientific article

Preparation of novel bicyclic piperazines by reduction of bicyclo[4.2.2]diketopiperazines: rearrangement involving 1,2-bond migration

Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation

scientific article

Synthesis of Carba-β-l-Fructopyranose and Carbacyclic Analogs of Topiramate, an Anticonvulsant Agent

Synthesis of Several Naturally Occurring Polyhalogenated Monoterpenes of the Halomon Class(1)

scientific article (publication date: 17 October 1997)

Synthesis of bis‐Phenylalanine, A Novel Eight‐Membered Cyclic Dipeptide

The preparation and human muscarinic receptor profiling of oxybutynin and N-desethyloxybutynin enantiomers

scientific article

The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008)

scientific article

List of works by Michael Parker

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors

Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy

Designing a diverse high-quality library for crystallography-based FBDD screening

Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes

Herpes simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-terminal tripeptide of the vaccinia D4 processivity factor

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)

Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family

Preparation of novel bicyclic piperazines by reduction of bicyclo[4.2.2]diketopiperazines: rearrangement involving 1,2-bond migration

Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation

Synthesis of Carba-β-l-Fructopyranose and Carbacyclic Analogs of Topiramate, an Anticonvulsant Agent

Synthesis of Several Naturally Occurring Polyhalogenated Monoterpenes of the Halomon Class(1)

Synthesis of bis‐Phenylalanine, A Novel Eight‐Membered Cyclic Dipeptide

The preparation and human muscarinic receptor profiling of oxybutynin and N-desethyloxybutynin enantiomers

The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008)