List of works - Sandra Duffy

(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp

article

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

2,4-Diaminothienopyrimidines as orally active antimalarial agents

scientific article published on 28 January 2014

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

scientific article

3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

scientific article published on 27 June 2017

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity

scientific article published on 19 August 2010

A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii

scientific article published on 29 July 2019

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A new quinoline epoxide from the Australian plant Drummondita calida ⬇️

scientific article

Albopunctatone, an antiplasmodial anthrone-anthraquinone from the Australian ascidian Didemnum albopunctatum

scientific article published on 8 June 2012

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents

scientific article

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

scientific article published on 29 March 2016

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

scientific article published on 10 June 2010

Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia ⬇️

scientific article published in August 2009

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. ⬇️

scientific article

Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras ⬇️

scientific article published in August 2009

Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp. ⬇️

scientific article

Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana

scientific article published on 24 March 2017

Aplidiopsamine A, an antiplasmodial alkaloid from the temperate Australian ascidian, Aplidiopsis confluata

scientific article published on 3 November 2010

Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds

scientific article published on 25 September 2014

Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)

Citronamides A and B, tetrapeptides from the Australian sponge Citronia astra

scientific article published in April 2009

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

scientific article

Development and Optimization of a Novel 384-Well Anti-Malarial Imaging Assay Validated for High-Throughput Screening ⬇️

scientific article published on January 1, 2012

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

scientific article

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian PlantEndiandraanthropophagorum ⬇️

article

Euodenine A: A Small-Molecule Agonist of Human TLR4

scientific article published on 07 February 2014

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

scientific article

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry

scientific article

Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay

scientific article

Identification of inhibitors of Plasmodium falciparum gametocyte development

scientific article

Identifying common metalloprotease inhibitors by protein fold types using Fourier transform mass spectrometry

scientific article published on 29 September 2007

Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex

scientific article published in February 2002

Kororamide A, a new tribrominated indole alkaloid from the Australian bryozoan Amathia tortuosa

article

Large-scale production of Plasmodium falciparum gametocytes for malaria drug discovery

scientific article published on 28 April 2016

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

scientific article

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

scientific article

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds

scientific article published on 21 July 2014

Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

scientific article published on 26 July 2013

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

scientific article published on 12 January 2017

Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance.

scientific article published on 13 April 2018

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle

scientific article

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.

scientific article published on 21 December 2016

Prenylated Flavonoids from the Roots of Tephrosia rhodesica

scientific article published on 13 August 2020

Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Repositioning: the fast track to new anti-malarial medicines?

scientific article

Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis

scientific article published on 14 December 2015

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

scientific article

Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

scientific article

Secoiridoids and Iridoids from Morinda asteroscepa

scientific article published on 27 August 2020

Selective anti-malarial minor groove binders

scientific article published on 13 May 2016

Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid

scientific article published on 15 July 2017

Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.

scientific article published on 4 February 2014

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

scientific article published on 21 November 2014

Thiaplakortones A-D: antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita

scientific article

Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata

scientific article published on 20 February 2017

Tomentosones A and B, hexacyclic phloroglucinol derivatives from the Thai shrub Rhodomyrtus tomentosa

scientific article published on 28 November 2011

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

Watsonianone A-C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana

scientific article published on 29 November 2012

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

article

List of works by Sandra Duffy

(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

2,4-Diaminothienopyrimidines as orally active antimalarial agents

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity

A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A new quinoline epoxide from the Australian plant Drummondita calida ⬇️

Albopunctatone, an antiplasmodial anthrone-anthraquinone from the Australian ascidian Didemnum albopunctatum

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia ⬇️

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. ⬇️

Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras ⬇️

Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp. ⬇️

Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana

Aplidiopsamine A, an antiplasmodial alkaloid from the temperate Australian ascidian, Aplidiopsis confluata

Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds

Chemical genetics of Plasmodium falciparum

Citronamides A and B, tetrapeptides from the Australian sponge Citronia astra

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

Development and Optimization of a Novel 384-Well Anti-Malarial Imaging Assay Validated for High-Throughput Screening ⬇️

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian PlantEndiandraanthropophagorum ⬇️

Euodenine A: A Small-Molecule Agonist of Human TLR4

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry

Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay

Identification of inhibitors of Plasmodium falciparum gametocyte development

Identifying common metalloprotease inhibitors by protein fold types using Fourier transform mass spectrometry

Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex

Kororamide A, a new tribrominated indole alkaloid from the Australian bryozoan Amathia tortuosa

Large-scale production of Plasmodium falciparum gametocytes for malaria drug discovery

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds

Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance.

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.

Prenylated Flavonoids from the Roots of Tephrosia rhodesica

Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura

Quinolone-3-diarylethers: a new class of antimalarial drug.

Repositioning: the fast track to new anti-malarial medicines?

Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

Secoiridoids and Iridoids from Morinda asteroscepa

Selective anti-malarial minor groove binders

Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid

Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

Thiaplakortones A-D: antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita

Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata

Tomentosones A and B, hexacyclic phloroglucinol derivatives from the Thai shrub Rhodomyrtus tomentosa

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

Watsonianone A-C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni