List of works by Fabrizio Carta

2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

scientific article published on 23 June 2020

4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

scientific article

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

scientific article published on 11 November 2011

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

scientific article published on 01 January 2015

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells

scientific article

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring.

scientific article

7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII

scientific article published on 18 December 2015

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.

scientific article published on 31 May 2013

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease

scientific article published on 24 September 2019

A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

scientific article

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

scientific article

A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors

scientific article published on 27 July 2019

A deadly spillover: SARS-CoV-2 outbreak

scientific article published on 23 April 2020

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

scientific article published on 28 May 2019

A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer

scientific article published on 01 December 2020

Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

scientific article published on 21 September 2017

Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium.

scientific article published in December 2017

Antiglaucoma carbonic anhydrase inhibitors: a patent review

scientific article published on 30 April 2013

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

scientific article published on 5 June 2012

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

scientific article published on 22 April 2013

Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations

scientific article published on 21 November 2016

Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity

scientific article published on 23 November 2015

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

scientific article published on 21 May 2019

Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases

scientific article published on 07 April 2020

Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis

scientific article published on 15 November 2019

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

scientific article published in Scientific Reports

CO2 Permeability of Rat Hepatocytes and Relation of CO2 Permeability to CO2 Production

scientific article published on 16 April 2018

CO2 and HCO3- Permeability of the Rat Liver Mitochondrial Membrane.

scientific article published on 24 October 2016

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

scientific article published on 7 June 2014

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

scientific article published on 14 October 2020

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies

scientific article

Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries ⬇️

scientific article published on 22 January 2019

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

scientific article published on 08 May 2013

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

scientific article published on 19 September 2017

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

scientific article published on 10 September 2015

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus.

scientific article published on 9 March 2017

Carbonic anhydrase inhibition and the management of glaucoma: a literature and patent review 2013-2019

scientific article published on 15 October 2019

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors.

scientific article published on 26 November 2015

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

scientific article published on 07 August 2019

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

scientific article published on 7 October 2009

Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.

scientific article published on 6 September 2009

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

scientific article published on 22 July 2009

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

scientific article published on 17 February 2011

Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties

scientific article published on 31 January 2014

Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.

scientific article published on 2 August 2013

Carbonic anhydrases and their functional differences in human and mouse sperm physiology

scientific article published on 6 November 2015

Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery

scientific article published on 23 November 2020

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.

scientific article published on 31 August 2012

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII

scientific article published on 28 September 2015

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies

scientific article

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.

scientific article published on 29 November 2016

Crystal Structure of a Tetrameric Type II β-Carbonic Anhydrase from the Pathogenic Bacterium Burkholderia pseudomallei

scientific article published on 12 May 2020

Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents

scientific article published on 29 July 2015

Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies

scientific article published on 03 May 2018

Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I-XIV

scientific article published on 15 May 2015

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis

scientific article published on 11 January 2017

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors

scientific article published in October 2004

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

scientific article published on 09 April 2018

Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma

scientific article published on 08 February 2016

Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents.

scientific article published on 6 January 2016

Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups

scientific article

Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors

scientific article published on 30 October 2019

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

scientific article published on 17 July 2018

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

scientific article published on 10 August 2017

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis

scientific article published on 21 May 2018

Discovery of new organoselenium compounds as antileishmanial agents

scientific article published on 31 January 2019

Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy

scientific article published on 13 June 2018

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

scientific article published on 11 December 2011

Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.

scientific article published on 27 December 2016

Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase.

scientific article published on 11 February 2015

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).

scientific article published on 14 March 2013

Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis

scientific article published on 10 September 2020

Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria

scientific article published on 17 January 2020

Exploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII).

scientific article published on 8 September 2014

Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies

scholarly article by Fabrizio Carta published in January 2016

From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes

scientific article published in November 2008

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

scientific article published on 17 June 2014

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines

scientific article published on 29 August 2018

Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.

scientific article published on 12 April 2013

In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with IX and XII hCA Inhibition

scientific article published on 21 August 2020

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

scientific article published on 01 December 2020

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

scientific article published on 10 April 2018

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones

scientific article published on 21 September 2014

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates.

scientific article published in December 2017

Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides

article

Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties

scientific article published on 26 June 2015

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

scientific article published on 28 November 2016

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors

scientific article

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111

scientific article published on 11 January 2016

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells.

scientific article published on 3 May 2016

Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action

scientific article published on 8 March 2017

Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009-2012).

scientific article published on 04 March 2013

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii.

scientific article

Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV

scientific article published on 17 May 2012

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.

scientific article published on 2 June 2016

Multivalent Carbonic Anhydrases Inhibitors

scientific article published on 28 October 2019

Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs

scientific article published on 17 October 2019

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs

scientific article published on 19 October 2016

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II

scientific article published on 06 February 2012

New natural product carbonic anhydrase inhibitors incorporating phenol moieties

scientific article published on 20 October 2015

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

scientific article

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

article

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

scientific article

Novel therapies for glaucoma: a patent review 2007 - 2011.

scientific article published on 23 December 2011

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

scientific article published on 15 August 2016

Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis

scientific article published on 18 April 2019

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

scientific article published on 08 September 2014

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

scientific article

Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action

scientific article published on 15 April 2015

Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against α-, β-, γ- and η-class enzymes

scientific article published on 08 October 2015

Polyamines and α-Carbonic Anhydrases

scientific article

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII

scientific article published on 01 May 2019

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

scientific article published in December 2021

Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models

scientific article published on 17 August 2016

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry.

scientific article published in December 2018

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors

scientific article published on 08 December 2020

Secondary and tertiary sulfonamides: a patent review (2008 - 2012).

scientific article

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition

scientific article published in PLoS ONE

Selenolesterase enzyme activity of carbonic anhydrases

scientific article published on 20 March 2020

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.

scientific article published in March 2012

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

scientific article published on 14 June 2011

Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity

scientific article published on 17 August 2019

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes

scientific article published on 01 January 2019

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor.

scientific article published on 17 May 2013

Sulfonamides and their isosters as carbonic anhydrase inhibitors.

scientific article

Sulfonamides: a patent review (2008 - 2012).

scientific article published on 15 June 2012

Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain

Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties

scientific article published on 27 June 2016

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis

scientific article published on 23 July 2019

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

scientific article published in December 2017

Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.

scientific article published on 18 March 2017

Synthesis of N'-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases.

scientific article published in March 2018

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action

scientific article published on 31 March 2015

Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms.

scientific article published on 27 September 2012

Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.

scientific article

Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.

scientific article published on 9 May 2017

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes.

scientific article published in December 2018

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

scientific article published on 05 August 2019

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity

scientific article published on 09 April 2020

The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies

scientific article

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy

scholarly article by Elena Andreucci et al published December 2019 in Journal of Enzyme Inhibition and Medicinal Chemistry

The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets.

scientific article published on January 2010

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

scientific article published on 01 December 2020

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

scientific article

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

scientific article

Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore

scientific article published in 2011

X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX

scientific article published on 14 February 2020

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

scientific article published on 16 May 2013

[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX

scientific article

α-Carbonic Anhydrases Possess Thioesterase Activity

scientific article published on 19 January 2015

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