List of works by Guy Whitley

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

scientific article

Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice.

scientific article published on 20 February 2004

Angiotensin II-induced inositol phosphate production in isolated rat zona glomerulosa and fasciculata/reticularis cells

scientific article published on 01 April 1987

Antiphospholipid antibodies prevent extravillous trophoblast differentiation

scientific article published on 01 March 2005

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.

scientific article published on 2 May 2018

BeWo cells stimulate smooth muscle cell apoptosis and elastin breakdown in a model of spiral artery transformation.

scientific article

Caffeine inhibits EGF-stimulated trophoblast cell motility through the inhibition of mTORC2 and Akt.

scientific article

Cell Culture Models of Human Trophoblast II: Trophoblast Cell Lines—A Workshop Report

article

Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26.

scientific article published on 10 March 2013

Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes

scientific article published on 01 December 1989

Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia

scientific article

Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia

scientific article

Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling.

scientific article published on 12 May 2015

Decidual regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia.

scientific article published on 7 February 2018

Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody

scientific article published on 01 February 1995

Differential role for ADP-ribosylation in gene expression during the activation of T lymphocytes by various stimuli

scientific article published on 01 June 1989

Dimethylarginine dimethylaminohydrolase (DDAH) regulates trophoblast invasion and motility through effects on nitric oxide

scientific article published on 18 August 2006

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

scientific article published on 13 September 2017

Effect of first-trimester serum from pregnant women with high-resistance uterine artery Doppler resistance on extravillous trophoblast invasion.

scientific article published on 23 January 2006

Effect of heparin and fractionated heparin on trophoblast invasion

scientific article published on 4 July 2007

Effects of low-molecular-weight and unfractionated heparin on trophoblast function

scientific article (publication date: August 2004)

Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

scientific article published in August 2003

Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia

scientific article published in September 2011

Endogenously produced nitric oxide inhibits endothelial cell growth as demonstrated using novel antisense cell lines.

scientific article published on September 2000

Endothelial cell adhesion molecule expression and lymphocyte adhesion to endothelial cells: effect of nitric oxide.

scientific article published on September 1997

Endothelium, Blood Vessels and Angiogenesis – A Workshop Report

scientific article published in April 2006

Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.

scientific article published on 16 May 2008

Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension

scientific article

Expression of intercellular adhesion molecule-1 (ICAM-1) on human thyroid cells lines correlated with their binding of lymphoblasts.

scientific article published on May 1990

Expression of voltage-dependent potassium channels in first trimester human placentae

scientific article published on 03 March 2014

Extraction and assay of cyclic nucleotides

scientific article published on 01 January 1994

Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cepsilon

scientific article

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.

scientific article published on 22 February 2007

First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli

scientific article published on 05 October 2018

First-trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine

scientific article published in February 2008

Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase

scientific article published on October 2002

Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide

scientific article

Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction.

scientific article published on 18 August 2016

Human cytomegalovirus-induced inhibition of cytotrophoblast invasion in a first trimester extravillous cytotrophoblast cell line.

scientific article

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

scientific article

Immune induction of major histocompatibility complex antigens on a human thyroid cell line (SGHTL-34)

scientific article published on 01 May 1989

Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance

scientific article

In Vitro Models to Study Trophoblast Function and Dysfunction— A Workshop Report

scientific article published on 01 April 2002

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function.

scientific article published on 12 February 2014

Increased apoptosis in first trimester extravillous trophoblasts from pregnancies at higher risk of developing preeclampsia

scientific article

Increased apoptosis, altered oxygen signaling, and antioxidant defenses in first-trimester pregnancies with high-resistance uterine artery blood flow

scientific article published on 2 September 2015

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

scientific article

Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL.

scientific article

Inhibition of nitric oxide synthase by antisense techniques: investigations of the roles of NO produced by murine macrophages

scientific article published on January 1997

International implementation in education and practice.

scientific article published in April 2009

Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism

scientific article published on November 2006

Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system

scientific article published on 12 January 2016

Letter to the editor: response to Dr Lala's letter-The effects of angiogenic growth factors on extravillous trophoblast invasion and motility

scientific article published on 01 July 2000

Macrophage polarisation affects their regulation of trophoblast behaviour

scientific article published on 09 September 2016

Making the difference visible

scientific article published on 01 October 2007

Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation.

scientific article published on 13 July 2017

Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice.

scientific article

Nitric oxide enhances thyroid peroxidase activity in primary human thyrocytes.

scientific article published in January 1998

Nitric oxide inhibits polyamine-induced apoptosis in the human extravillous trophoblast cell line SGHPL-4.

scientific article published on May 2003

Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP-dependent mechanism and independently of caspase 3 nitrosylation.

scientific article published on July 2003

Nitric oxide stimulates cyclic GMP in human thyrocytes.

scientific article published on April 1993

Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts.

scientific article published on 20 December 2013

OS081. Novel KCNQ3/KCNE5 isoform protein and mRNA expression in first trimester human placentae.

scientific article published on 13 June 2012

Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.

scientific article

Oxygen modulates human decidual natural killer cell surface receptor expression and interactions with trophoblasts ⬇️

scientific article published on 17 September 2014

Phospholipid metabolism in the adrenal cortex

scientific article published on 01 February 1985

Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia

scientific article published on 01 March 1998

Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia

scientific article published on 01 July 1993

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide.

scientific article published on July 1993

Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces

scientific article published on August 2010

Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine

scientific article

Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

scientific article

S-nitrosylation of proteins at the leading edge of migrating trophoblasts by inducible nitric oxide synthase promotes trophoblast invasion.

scientific article

SGHTL-34, a thyrotrophin-responsive immortalised human thyroid cell line generated by transfection.

scientific article

Shear stress and spiral artery remodelling: the effects of low shear stress on trophoblast-induced endothelial cell apoptosis

scientific article published on 14 December 2010

Signal-transduction

scientific article published in Nature

Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology?

scientific article

The cell adhesion molecule, VCAM-1, is selectively elevated in serum in pre-eclampsia: does this indicate the mechanism of leucocyte activation?

scientific article published on 01 February 1995

The effect of basic fibroblast growth factor on the growth and function of human thyrocytes

scientific article published on 01 February 1993

The effects of ACTH, serotonin, K+ and angiotensin analogues on 32P incorporation into phospholipids of the rat adrenal cortex: basis for an assay method using zona glomerulosa cells.

scientific article published on September 1984

The effects of angiogenic growth factors on extravillous trophoblast invasion and motility

scientific article

The regulation of trophoblast migration across endothelial cells by low shear stress: consequences for vascular remodelling in pregnancy

scientific article

The role of tumour-derived iNOS in tumour progression and angiogenesis

scientific article

Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion.

scientific article published on 25 January 2005

Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP.

scientific article published on May 2000

Trophoblast Cell Lines: a response to the Workshop Report by King et al

scientific article published on 01 February 2001

Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and β-catenin mediated up-regulation of inducible nitric oxide synthase

scientific article published on 01 May 2005

Trophoblast invasion of spiral arteries: a novel in vitro model

scientific article published on February 2002

Trophoblast signalling: knowns and unknowns--a workshop report

scientific article published on 01 April 2005

Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling

scientific article

Trophoblast-induced changes in C-x-C motif chemokine 10 expression contribute to vascular smooth muscle cell dedifferentiation during spiral artery remodeling

scientific article published on 3 January 2013

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions.

scientific article

all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.

scientific article

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