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List of works by Judith M Gottwein

Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

scientific article published on 23 September 2013

Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

scientific article published on 20 May 2015

Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.

scientific article

Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7.

scientific article published on August 2013

Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

scientific article published on 30 July 2021

Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

scientific article published on 15 March 2018

Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

scientific article published on 28 December 2012

Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems

scientific article published on January 2008

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.

scientific article

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

scientific article published on February 2009

Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

scientific article

Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.

scientific article published on 12 June 2011

Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors

scientific article published on 18 November 2013

Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1-7 and Escape Variants.

scientific article published on 21 December 2017

Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors

scientific article published on 27 March 2017

Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations

scientific article

Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

scientific article

Etiologic diagnosis of Capnocytophaga canimorsus meningitis by broad-range PCR.

scientific article published in February 2006

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

scientific article published on 05 June 2019

HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

scientific article published on 15 February 2018

Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

scientific article published on 28 March 2016

Hepatitis C virus host cell interactions uncovered

scientific article

High Reproducibility of ELISPOT Counts from Nine Different Laboratories.

scientific article

High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

scientific article published in Scientific Reports

Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection.

scientific article

Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

scientific article

Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

scientific article published on 13 December 2013

Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

scientific article

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

scientific article

Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

scientific article published on 18 September 2013

Identification of novel neutralizing determinants for protection against hepatitis C virus

scientific article published in 2022

In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

scientific article published on 16 July 2021

Log-Normal ELISPOT spot size distribution permits count harmonization among different laboratories

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.

scientific article

Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

scientific article published on 7 August 2013

Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

scientific article

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

scientific article

Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.

scientific article published on 24 May 2014

Productive homologous and non-homologous recombination of hepatitis C virus in cell culture.

scientific article

Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization

scientific article published on 10 July 2001

Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.

scientific article published on 25 November 2010

Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

article

Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

scientific article published on 21 July 2016

Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.

scientific article

Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses.

scientific article published on 3 August 2007

Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

scientific article

Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

scientific article

Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

scientific article

[Transmissible spongiform encephalopathies in humans]

article

p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ

scientific article published on 01 December 2009

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