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List of works by Willem J.H. van Berkel

19F NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols

article published in 2001

19F NMR study on the biodegradation of fluorophenols by various Rhodococcus species

scientific article published on 01 January 1998

19F NMR study on the biological Baeyer-Villiger oxidation of acetophenones.

scientific article

19F NMR study on the regiospecificity of hydroxylation of tetrafluoro-4-hydroxybenzoate by wild-type and Y385F p-hydroxybenzoate hydroxylase: evidence for a consecutive oxygenolytic dehalogenation mechanism

scientific article published on 01 November 1997

19F nuclear magnetic resonance as a tool to investigate microbial degradation of fluorophenols to fluorocatechols and fluoromuconates.

scientific article published on April 1998

19F-NMR study on the pH-dependent regioselectivity and rate of the ortho-hydroxylation of 3-fluorophenol by phenol hydroxylase from Trichosporon cutaneum. Implications for the reaction mechanism

scientific article published on 01 December 1993

3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor

scientific article

3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities.

scientific article

A His-tag based immobilization method for the preparation and reconstitution of apoflavoproteins.

scientific article published in January 2003

A Study of p-Hydroxybenzoate Hydroxylase from Pseudomonas fluorescens. Improved Purification, Relative Molecular Mass, and Amino Acid Composition ⬇️

scientific article published on November 1, 1979

A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para-Phenol Oxidases.

scientific article published on 14 January 2018

A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: structural determinants of redox potential

scientific article published on September 2005

A novel oxidoreductase family sharing a conserved FAD-binding domain.

scientific article published on June 1998

A single loop is essential for the octamerization of vanillyl alcohol oxidase.

scientific article published on 23 May 2016

Aldonolactone oxidoreductases

scientific article published on January 2014

Alternative coenzymes for biocatalysis

scientific article published on 01 February 2019

Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus

scientific article published on 06 December 2019

Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions

scientific article published on 05 July 2019

Bifunctional immobilization of a hyperthermostable endo-β-1,3-glucanase.

scientific article

Biocatalytic potential of laccase-like multicopper oxidases from Aspergillus niger

scientific article

Biochemical characterization of the major sorghum grain peroxidase

scientific article published on 01 May 2006

Bioluminescent and spectroscopic properties of His-Trp-Tyr triad mutants of obelin and aequorin.

scientific article published on 25 March 2013

Boosting LPMO-driven lignocellulose degradation by polyphenol oxidase-activated lignin building blocks

scientific article

Catalytic and hydrodynamic properties of styrene monooxygenases from Rhodococcus opacus 1CP are modulated by cofactor binding.

scientific article published on 4 June 2015

Catalytic mechanism of the oxidative demethylation of 4-(methoxymethyl)phenol by vanillyl-alcohol oxidase. Evidence for formation of a p-quinone methide intermediate

scientific article published on 01 July 1997

Changing the substrate reactivity of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica HBP1 by directed evolution.

scientific article published on 3 December 2001

Chaotropic heat treatment resolves native-like aggregation of a heterologously produced hyperthermostable laminarinase.

scientific article

Characterization of a bacterial pyranose 2-oxidase from Arthrobacter siccitolerans

Chemical modification of sulfhydryl groups in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Involvement in catalysis and assignment in the sequence

scientific article published on 01 December 1984

Chemical modification of tyrosine residues in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens: assignment in sequence and catalytic involvement

scientific article published on 01 July 1986

Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase.

scientific article published on 9 July 2002

Colorful Packages: Encapsulation of Fluorescent Proteins in Complex Coacervate Core Micelles.

scientific article

Conversion of 2-fluoromuconate to cis-dienelactone by purified enzymes of Rhodococcus opacus 1cp

scientific article

Covalent flavinylation enhances the oxidative power of vanillyl-alcohol oxidase

article

Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity

scientific article

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton [...]

scientific article

Crystallization and preliminary X-ray analysis of the flavoenzyme vanillyl-alcohol oxidase from Penicillium simplicissimum.

scientific article

Deflavination and reconstitution of flavoproteins.

scientific article published on November 2003

Degradation of 3,4-dichloro- and 3,4-difluoroaniline by Pseudomonas fluorescens 26-K.

scientific article

Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene

scientific article published on 01 March 1988

Dimerization of Proline Dehydrogenase from Thermus thermophilus Is Crucial for Its Thermostability.

scientific article published on 17 April 2019

Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols

scientific article published on 01 September 2000

Discovery of the combined oxidative cleavage of plant xylan and cellulose by a new fungal polysaccharide monooxygenase

scientific article published on 17 July 2015

Distant residues mediate picomolar binding affinity of a protein cofactor ⬇️

scientific article published on January 1, 2012

Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases.

scientific article published on 29 May 2018

Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential

scientific article published on 18 July 2015

Editorial: , a Source of Biocatalytic Tools

scientific article published on 16 April 2019

Elucidation of the 4-hydroxyacetophenone catabolic pathway in Pseudomonas fluorescens ACB.

scientific article published on 23 May 2008

Enantioselective hydroxylation of 4-alkylphenols by vanillyl alcohol oxidase

Encapsulation into complex coacervate core micelles promotes EGFP dimerization

scientific article published on 19 April 2017

Encapsulation of GFP in Complex Coacervate Core Micelles.

scientific article published on 16 April 2015

Engineering of microheterogeneity-resistant p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.

scientific article published in December 1990

Enzymatic synthesis of vanillin.

scientific article published in June 2001

FAD C(4a)-hydroxide stabilized in a naturally fused styrene monooxygenase.

scientific article

FRET Reveals the Formation and Exchange Dynamics of Protein-Containing Complex Coacervate Core Micelles

scientific article published on 26 September 2018

Flavin dependent monooxygenases

scientific article

Flavin-dependent N-hydroxylating enzymes: distribution and application

scientific article published on 05 June 2020

Flavodoxins

scientific article published on 01 January 1994

Flavoenzymes.

scientific article

Frontier orbital study on the 4-hydroxybenzoate-3-hydroxylase-dependent activity with benzoate derivatives.

scientific article published on June 1992

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus.

scientific article published on 16 January 2018

Functional annotation and characterization of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1.

scientific article

Functional assignment of Glu386 and Arg388 in the active site of L-galactono-gamma-lactone dehydrogenase.

scientific article published on 6 September 2009

Functional characterization and stability improvement of a 'thermophilic-like' ene-reductase from Rhodococcus opacus 1CP

scientific article

Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C.

scientific article published on 15 April 2009

Galactonolactone oxidoreductase from Trypanosoma cruzi employs a FAD cofactor for the synthesis of vitamin C

scientific article published on 21 March 2011

Genome analysis and physiological comparison of Alicycliphilus denitrificans strains BC and K601(T.).

scientific article

Genome sequences of Alicycliphilus denitrificans strains BC and K601T

scientific article

High yields of active Thermus thermophilus proline dehydrogenase are obtained using maltose-binding protein as a solubility tag.

scientific article

Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells.

scientific article published on 6 April 2005

Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

scientific article published on 06 February 2019

Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases

scientific article

Identification of a Baeyer-Villiger monooxygenase sequence motif

scientific article published on 01 May 2002

Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases.

scientific article

Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CP.

scientific article published on 29 May 2009

Identification of fluoropyrogallols as new intermediates in biotransformation of monofluorophenols in Rhodococcus opacus 1cp.

scientific article published on May 2000

Identification of lipoxygenase inhibitory peptides from beta-casein by using SPOT synthesis.

scientific article

Identification of the peroxidase-generated intermolecular dityrosine cross-link in bovine α-lactalbumin

scientific article published on 16 December 2010

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation-Strain-Promoted (4 + 2) Cycloaddition

scientific article published on 6 March 2017

Influence of Lytic Polysaccharide Monooxygenase Active Site Segments on Activity and Affinity ⬇️

scientific article published on 10 December 2019

Inhibition of enzymatic browning of chlorogenic acid by sulfur-containing compounds

scientific article published on 26 March 2012

Interdomain binding of NADPH in p-Hydroxybenzoate Hydroxylase as Suggested by Kinetic, Crystallographic and Modeling Studies of Histidine 162 and Arginine 269 Variants ⬇️

scientific article published on August 14, 1998

Inversion of stereospecificity of vanillyl-alcohol oxidase

scientific article

Kinetic mechanism of vanillyl-alcohol oxidase with short-chain 4-alkylphenols

scientific article published on 01 May 1998

Laboratory-evolved vanillyl-alcohol oxidase produces natural vanillin.

scientific article

Large-scale preparation and reconstitution of apo-flavoproteins with special reference to butyryl-CoA dehydrogenase from Megasphaera elsdenii. Hydrophobic-interaction chromatography

scientific article published on 01 December 1988

Lipoamide dehydrogenase from Azotobacter vinelandii. The role of the C-terminus in catalysis and dimer stabilization

scientific article published on 01 July 1992

Lipoamide dehydrogenase from Azotobacter vinelandii: site-directed mutagenesis of the His450-Glu455 diad. Kinetics of wild-type and mutated enzymes

scientific article published on 01 July 1992

Lipoamide dehydrogenase from Azotobacter vinelandii: site-directed mutagenesis of the His450-Glu455 diad. Spectral properties of wild type and mutated enzymes

scientific article published on 01 December 1991

Lys42 and Ser42 variants of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens reveal that Arg42 is essential for NADPH binding

scientific article

Lytic polysaccharide monooxygenases from Myceliophthora thermophila C1 differ in substrate preference and reducing agent specificity

scientific article published on 31 August 2016

Mass spectrometric fragmentation patterns discriminate C1- and C4-oxidised cello-oligosaccharides from their non-oxidised and reduced forms

scientific article published on 26 January 2020

Mercuration of vanillyl-alcohol oxidase fromPenicillium simplicissimumgenerates inactive dimers

scientific article published on 01 January 1997

Molecular Cloning, Sequencing, and Heterologous Expression of the vaoA Gene from Penicillium simplicissimum CBS 170.90 Encoding Vanillyl-Alcohol Oxidase ⬇️

scientific article published on April 3, 1998

Molecular relaxation spectroscopy of flavin adenine dinucleotide in wild type and mutant lipoamide dehydrogenase from Azotobacter vinelandii

scientific article published on 01 August 1992

N-terminus determines activity and specificity of styrene monooxygenase reductases.

scientific article published on 6 September 2017

NMR characterization of a 264-residue hyperthermostable endo-β-1,3-glucanase

scientific article published on 12 November 2009

Occurrence and biocatalytic potential of carbohydrate oxidases.

scientific article published on January 2006

On the FAD-induced dimerization of apo-lipoamide dehydrogenase from Azotobacter vinelandii and Pseudomonas fluorescens. Kinetics of reconstitution

scientific article published on 01 May 1991

On the enigma of old yellow enzyme's spectral properties.

scientific article published on December 1982

On the origin of vanillyl alcohol oxidases.

scientific article published on 4 April 2018

Oxidoreductases on their way to industrial biotransformations

scientific article

Oxygen activation of apo-obelin-coelenterazine complex

scientific article published on 12 March 2013

Peroxygenase-Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol.

scientific article published on 26 November 2015

Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability

scientific article

Phe161and Arg166variants ofp-hydroxybenzoate hydroxylase

scholarly article by Michel H.M. Eppink published in January 1999

Phenol hydroxylase from Bacillus thermoglucosidasius A7, a two-protein component monooxygenase with a dual role for FAD.

scientific article published on 10 September 2003

Potato and mushroom polyphenol oxidase activities are differently modulated by natural plant extracts.

scientific article published on 27 December 2013

Proline dehydrogenase from Thermus thermophilus does not discriminate between FAD and FMN as cofactor.

scientific article published on 3 March 2017

Properties of the complexes of riboflavin 3',5'-bisphosphate and the apoflavodoxins from Megasphaera elsdenii and Desulfovibrio vulgaris

scientific article published on 01 December 1986

Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD

scientific article (publication date: 15 September 1992)

Purification and properties of p-hydroxybenzoate hydroxylases from Rhodococcus strains.

scientific article published in August 2001

Quantification of the catalytic performance of C1-cellulose-specific lytic polysaccharide monooxygenases

scientific article

Real-time enzyme dynamics illustrated with fluorescence spectroscopy of p-hydroxybenzoate hydroxylase.

scientific article published on 21 February 2006

Redox properties of vanillyl-alcohol oxidase

scientific article

Reduction kinetics of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1.

scientific article published on 17 May 2012

Reductive deamination as a new step in the anaerobic microbial degradation of halogenated anilines.

scientific article

Regio- and Stereospecific Conversion of 4-Alkylphenols by the Covalent Flavoprotein Vanillyl-Alcohol Oxidase ⬇️

scientific article published on November 1, 1998

Reversible resolution of flavin and pterin cofactors of His-tagged Escherichia coli DNA photolyase.

scientific article published on 28 July 2006

Role of Tyr201 and Tyr385 in substrate activation by p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.

scientific article

Role of key residues of obelin in coelenterazine binding and conversion into 2-hydroperoxy adduct

scientific article published on 28 August 2013

Selective cysteine-->serine replacements in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens allow the unambiguous assignment of Cys211 as the site of modification by spin-labeled p-chloromercuribenzoate

scientific article published on 01 June 1994

Seven new mutations in the nicotinamide adenine dinucleotide reduced-cytochrome b(5) reductase gene leading to methemoglobinemia type I.

scientific article

Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme

scientific article published on 25 September 2006

Special Issue: Flavoenzymes

scientific article published on 06 August 2018

Spectral and catalytic properties of aryl-alcohol oxidase, a fungal flavoenzyme acting on polyunsaturated alcohols.

scientific article published on August 2005

Stalled flavodoxin binds its cofactor while fully exposed outside the ribosome.

scientific article published on 11 June 2015

Structural Motifs of Wheat Straw Lignin Differ in Susceptibility to Degradation by the White-Rot Fungus Ceriporiopsis subvermispora

scientific article published on 05 November 2019

Structural analysis of flavinylation in vanillyl-alcohol oxidase

scientific article

Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action

scientific article

Studies on the active site of rat glutathione S-transferase isoenzyme 4-4. Chemical modification by tetrachloro-1,4-benzoquinone and its glutathione conjugate

scientific article published on 01 May 1989

StyA1 and StyA2B from Rhodococcus opacus 1CP: a multifunctional styrene monooxygenase system

scientific article published on 30 July 2010

Subcellular localization of vanillyl-alcohol oxidase in Penicillium simplicissimum.

scientific article

Substitution of Arg214 at the substrate-binding site of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens

scientific article published on December 1, 1992

Substrate binding tunes the reactivity of hispidin 3-hydroxylase, a flavoprotein monooxygenase involved in fungal bioluminescence

scientific article published on 11 September 2020

The Ribosome Restrains Molten Globule Formation in Stalled Nascent Flavodoxin

scientific article

The VAO/PCMH flavoprotein family.

scientific article

The antibrowning agent sulfite inactivates Agaricus bisporus tyrosinase through covalent modification of the copper-B site

scientific article

The conformational stability of the redox states of lipoamide dehydrogenase from Azotobacter vinelandii ⬇️

scientific article published on December 18, 1991

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum'). ⬇️

scientific article

The growing VAO flavoprotein family.

scientific article published on 06 February 2008

The importance of monopole-monopole and monopole-dipole interactions on the binding of NADPH and NADPH analogues to p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Effects of pH and ionic strength

scientific article published on 01 March 1984

The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths

scientific article published on 6 October 2017

The intrinsic fluorescence of apo-obelin and apo-aequorin and use of its quenching to characterize coelenterazine binding.

scientific article published on 6 May 2009

The oxidation of thiols by flavoprotein oxidases: a biocatalytic route to reactive thiocarbonyls

scientific article published on 05 October 2014

The reaction kinetics of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1 provide an understanding of the para-hydroxylation enzyme catalytic cycle.

scientific article published on 15 October 2013

The temperature and pH dependence of some properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens

scientific article published on 01 February 1989

Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties

scientific article

Transient-state kinetic analysis of complex formation between photoprotein clytin and GFP from jellyfish Clytia gregaria.

scientific article published on 25 January 2016

Tuning of pKa values activates substrates in flavin-dependent aromatic hydroxylases

scientific article published on 02 February 2020

Tuning of the product spectrum of vanillyl-alcohol oxidase by medium engineering

scientific article published in August 2001

Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase

scientific article published on 17 July 2017

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

scientific article published on 02 August 2018

Tyr217 and His213 are important for substrate binding and hydroxylation of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1

scientific article published on 27 January 2016

Unanimous Model for Describing the Fast Bioluminescence Kinetics of Ca2+ -regulated Photoproteins of Different Organisms.

scientific article published on 12 November 2016

Vanillyl-alcohol oxidase, a tasteful biocatalyst

article

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