List of works - Lina M. Obeid

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

scientific article (publication date: May 2011)

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

scientific article

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

scientific article

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

scientific article published on 13 August 2007

A role of sphingosine kinase 1 in head and neck carcinogenesis

scientific article published on 5 January 2011

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

scientific article published on 15 June 2009

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

scientific article

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

scientific article

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

scientific article published on 27 June 2006

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

scientific article published on 25 January 2007

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

scientific article published on 15 February 2007

An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown ⬇️

scientific article published on January 1, 2010

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

scientific article published on May 1996

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

scientific article published in October 2002

Bioactive sphingolipids in the modulation of the inflammatory response.

scientific article

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

scientific article published on 28 January 2002

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

scientific article published on 19 October 2011

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

scientific article published on 01 June 2006

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

scientific article published on 29 February 2012

Ceramide and the regulation of apoptosis and the stress response.

scientific article published on July 1996

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

scientific article

Ceramide inhibits phospholipase D in a cell-free system

scientific article published on 01 October 1996

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

scientific article published on 12 January 2009

Ceramide synthases at the centre of sphingolipid metabolism and biology

scientific article

Ceramide: a stress signal and mediator of growth suppression and apoptosis.

scientific article

Ceramide: an endogenous regulator of apoptosis and growth suppression.

scientific article

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

scientific journal article

Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.

scientific article published on 9 June 2006

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

scientific article

Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

scientific article published on 01 November 2019

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

scientific article (publication date: 21 September 2001)

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

scientific article

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

scientific article published on 18 January 2002

Defining a role for sphingosine kinase 1 in p53-dependent tumors.

scientific article published on 18 July 2011

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis ⬇️

scientific article published on December 10, 2010

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

scientific article

Dihydroceramide-based response to hypoxia

scientific article published in 2012

Dihydroceramide-based response to hypoxia.

scientific article

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

scientific article published on 8 November 2005

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

scientific article

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

scientific article

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

scientific article published on 26 February 2004

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

scientific article published on 24 November 2007

Effect of sphingosine kinase 1 inhibition on blood pressure ⬇️

scientific article published on October 29, 2012

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

scientific article published on 29 April 2013

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

scientific article

Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

scientific article published on September 2000

Functions of neutral ceramidase in the Golgi apparatus

scientific article published on 28 August 2018

Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis

scientific article

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

scientific article published on 01 May 1998

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

scientific article

Golgi fragmentation is associated with ceramide-induced cellular effects.

scientific article

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

scientific article published on 07 March 2008

ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae

scientific article published on 29 January 2009

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase ⬇️

scientific article published on November 7, 1997

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

scientific article

Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity

scientific article published on 01 April 2001

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

scientific article published on 3 August 2012

Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis

scientific article

Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

scientific article published in August 2002

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

scientific article published on 22 August 2006

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

scientific article

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

scientific article published on November 2003

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

scientific article published on 01 December 1997

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

scientific article

Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease

scientific article published on 01 March 1986

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

scientific article published on August 31, 2012

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

scientific article published on 30 December 2005

Many ceramides.

scientific article

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

scientific article

Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.

scientific article published on 9 March 2006

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

scientific article published on 6 January 2003

Molecular targeting of acid ceramidase: implications to cancer therapy.

scientific article published on August 2008

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

scientific article

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner ⬇️

scientific article published on July 24, 2012

Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells.

scientific article published on 31 January 2006

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

scientific article (publication date: 20 September 2002)

PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

scientific article published on 16 August 2019

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation

scientific article published on 20 October 2011

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

scientific article

Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.

scientific article published on March 2006

Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases

scientific article published on 26 June 2019

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

scientific article published on 9 October 2006

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

scientific article published on February 18, 2011

Regulation of cyclin-dependent kinase 2 activity by ceramide

scientific article published on 01 December 2000

Regulation of protein kinase C and role in cancer biology.

scientific article

Role for ceramide in cell cycle arrest.

scientific article published on February 1995

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

scientific article

Role for sphingosine kinase 1 in colon carcinogenesis.

scientific article published on 29 September 2008

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

scientific article

Role of ceramide in cellular senescence

scientific article

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

scientific article (publication date: 5 September 2003)

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

scientific article

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

scientific article published on 01 December 2001

Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.

scientific article published on June 1997

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

scientific article

Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis

scientific article

Sphingolipids in mitochondria.

scientific article published on 30 September 2016

Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis

scientific article published on 01 June 2000

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

scientific article

Sphingosine Kinase 1 in Cancer ⬇️

scientific article published on January 1, 2013

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

scientific article

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

scientific article published on 13 June 2013

Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.

scientific article published on 30 November 2007

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation

scientific article published on 09 August 2013

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

scientific article

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

scientific article

Sphingosine-1-phosphate receptor 2

scientific article

Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis.

scientific article published on 17 September 2004

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy ⬇️

scientific article published on August 1, 2011

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

scientific article

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

scientific article published on 11 October 2013

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

scientific article published on 04 January 2021

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors ⬇️

scientific article published on July 16, 2012

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

scientific article

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

scientific article

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

scientific article

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

scientific article (publication date: August 2003)

Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2

scientific article published on 01 December 1997

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

scientific article published on 14 February 2005

Use of yeast as a model system for studies of sphingolipid metabolism and signaling

scientific article published on 01 January 2000

Yeast sphingolipid metabolism: clues and connections.

scientific article published on February 2004

Yeast sphingolipids: metabolism and biology.

scientific article

Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function

scientific article published on 10 August 2006

Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging.

scientific article

p53 and regulation of bioactive sphingolipids ⬇️

scientific article published on October 28, 2010

List of works by Lina M. Obeid

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

A role of sphingosine kinase 1 in head and neck carcinogenesis

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown ⬇️

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

Bioactive sphingolipids in the modulation of the inflammatory response.

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

Ceramide and the regulation of apoptosis and the stress response.

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

Ceramide inhibits phospholipase D in a cell-free system

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

Ceramide synthases at the centre of sphingolipid metabolism and biology

Ceramide: a stress signal and mediator of growth suppression and apoptosis.

Ceramide: an endogenous regulator of apoptosis and growth suppression.

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

Defining a role for sphingosine kinase 1 in p53-dependent tumors.

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis ⬇️

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

Dihydroceramide-based response to hypoxia

Dihydroceramide-based response to hypoxia.

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

Effect of sphingosine kinase 1 inhibition on blood pressure ⬇️

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

Functions of neutral ceramidase in the Golgi apparatus

Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

Golgi fragmentation is associated with ceramide-induced cellular effects.

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase ⬇️

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis

Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

Many ceramides.

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

Molecular targeting of acid ceramidase: implications to cancer therapy.

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner ⬇️

Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells.

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation