List of works - Nicholas Funderburg

A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy.

scientific article

Alcohol and dietary factors associate with gut integrity and inflammation in HIV-infected adults.

scientific article published on 9 November 2016

Alterations in regulatory T cell subpopulations seen in preterm infants

scientific article

Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons

article

Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy

scientific article published on 2 October 2015

Altered intestinal permeability and fungal translocation in Ugandan children with HIV

scientific article published on 01 July 2019

Anaemia is associated with monocyte activation in HIV-infected adults on antiretroviral therapy

scientific article

Anisocytosis and leukocytosis are independently related to survival after transcatheter aortic valve replacement.

scientific article published on 23 January 2018

Brief Report: CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy

scientific article published on June 2016

Brief Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection.

scientific article published on 4 November 2016

CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes

scientific article published on 01 June 2019

CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis

scientific article published on 25 September 2020

Cellular fatty acid synthase is required for late stages of HIV-1 replication.

scientific article published on 29 September 2017

Changes in oxidized lipids drive the improvement in monocyte activation and vascular disease after statin therapy in HIV.

scientific article

Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation.

scientific article published in September 2013

Coagulation and morbidity in treated HIV infection

scientific article

Comprehensive assessment of the arginine pathway and its relationship to inflammation in HIV.

scientific article

Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.

scientific article

Decreased IL-7 responsiveness is related to oxidative stress in HIV disease

scientific article

Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients.

scientific article published on 18 July 2012

Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine

scientific article

Effect of 24 weeks of statin therapy on systemic and vascular inflammation in HIV-infected subjects receiving antiretroviral therapy

scientific article published on 09 January 2014

Effect of statin on arginine metabolites in treated HIV-infection.

scientific article published on 28 September 2017

Effects of atorvastatin on biomarkers of immune activation, inflammation, and lipids in virologically suppressed, human immunodeficiency virus-1-infected individuals with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group Stu

scientific article

Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients

scientific article (publication date: 6 October 2010)

Equivalent Decline in Inflammation Markers with Tenofovir Disoproxil Fumarate vs. Tenofovir Alafenamide

scientific article published on 11 October 2016

Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

scientific article published on 7 June 2011

Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV

scientific article published on 04 April 2019

Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection

scientific article

HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease

scientific article

HIV-exposed-uninfected infants have increased inflammation and monocyte activation

scientific article published on 01 April 2019

HIV-positive youth who are perinatally infected have impaired endothelial function.

scientific article published on 5 June 2017

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

scientific article published on 23 September 2019

Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

scientific article published on 17 February 2018

High levels of self-reported prescription opioid use by HIV-positive individuals

scientific article published on 20 June 2016

Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.

scholarly article

Identification of Immune Activation Profiles That May Predict Morbidity During Antiretroviral Therapy Treated HIV Infection.

scientific article published on 13 May 2016

Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells

scientific article published on October 2011

Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression

scientific article published in April 2012

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

scientific article

Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection

scientific article published on 30 November 2015

Inflammation, Immune Activation, and Antiretroviral Therapy in HIV

scientific article

Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions

scientific article published on 04 October 2016

Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease

scientific article

Interferon-alpha administration enhances CD8+ T cell activation in HIV infection

scientific article

Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers

scientific article

Lipid Abnormalities and Inflammation in HIV Inflection

scientific article published on 31 May 2016

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

scientific article published on 01 June 2019

Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis.

scientific article

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms

scientific article published on 01 October 2020

Markers of coagulation and inflammation often remain elevated in ART-treated HIV-infected patients

scientific article

Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals.

scientific article published on 18 January 2013

Membrane damage and repair in primary monocytes exposed to human β-defensin-3

scientific article

Microbial translocation, immune activation, and HIV disease

scientific article published on 11 October 2012

Oxidized LDL Levels Are Increased in HIV Infection and May Drive Monocyte Activation.

scientific article published on June 2015

Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy

scientific article published on 22 July 2013

Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections

scientific article published on August 2013

Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis

scientific article

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

scientific article published on 16 January 2013

Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+ individuals.

scientific article

Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV.

scientific article published on 6 October 2017

Rosuvastatin Decreases Intestinal Fatty Acid Binding Protein (I-FABP), but Does Not Alter Zonulin or Lipopolysaccharide Binding Protein (LBP) Levels, in HIV-Infected Subjects on Antiretroviral Therapy

scientific article published on January 2016

Rosuvastatin preserves renal function and lowers cystatin C in HIV-infected subjects on antiretroviral therapy: the SATURN-HIV trial

scientific article

Rosuvastatin reduces vascular inflammation and T-cell and monocyte activation in HIV-infected subjects on antiretroviral therapy

scientific article

Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy ⬇️

scientific article

SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.

scientific article published on 15 December 2015

Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection

scientific article

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome

scientific article

Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection

scientific article

Soluble TWEAK may predict carotid atherosclerosis in treated HIV infection.

scientific article

Soluble Urokinase Plasminogen Activator Receptor Is Predictive of Non-AIDS Events During Antiretroviral Therapy-mediated Viral Suppression

scientific article published on 01 August 2019

Statin Therapy Does Not Reduce Liver Fat Scores in Patients Receiving Antiretroviral Therapy for HIV Infection

article

Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects

scientific article published on 11 March 2013

The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes ⬇️

scientific article published on October 1, 2011

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial

scientific article published on 15 April 2013

Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis

scientific article

Transcriptional Profiling Identifies Mechanisms Associated With Platelet Activation in HIV Infection

scientific article published on 01 February 2018

Treatment of HIV infection with a raltegravir-based regimen increases LDL levels, but improves HDL cholesterol efflux capacity.

scientific article

List of works by Nicholas Funderburg

A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy.

Alcohol and dietary factors associate with gut integrity and inflammation in HIV-infected adults.

Alterations in regulatory T cell subpopulations seen in preterm infants

Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons

Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy

Altered intestinal permeability and fungal translocation in Ugandan children with HIV

Anaemia is associated with monocyte activation in HIV-infected adults on antiretroviral therapy

Anisocytosis and leukocytosis are independently related to survival after transcatheter aortic valve replacement.

Brief Report: CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy

Brief Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection.

CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes

CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis

Cellular fatty acid synthase is required for late stages of HIV-1 replication.

Changes in oxidized lipids drive the improvement in monocyte activation and vascular disease after statin therapy in HIV.

Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation.

Coagulation and morbidity in treated HIV infection

Comprehensive assessment of the arginine pathway and its relationship to inflammation in HIV.

Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.

Decreased IL-7 responsiveness is related to oxidative stress in HIV disease

Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients.

Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine

Effect of 24 weeks of statin therapy on systemic and vascular inflammation in HIV-infected subjects receiving antiretroviral therapy

Effect of statin on arginine metabolites in treated HIV-infection.

Effects of atorvastatin on biomarkers of immune activation, inflammation, and lipids in virologically suppressed, human immunodeficiency virus-1-infected individuals with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group Stu

Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients

Equivalent Decline in Inflammation Markers with Tenofovir Disoproxil Fumarate vs. Tenofovir Alafenamide

Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV

Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection

HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease

HIV-exposed-uninfected infants have increased inflammation and monocyte activation

HIV-positive youth who are perinatally infected have impaired endothelial function.

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

High levels of self-reported prescription opioid use by HIV-positive individuals

Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.

Identification of Immune Activation Profiles That May Predict Morbidity During Antiretroviral Therapy Treated HIV Infection.

Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells

Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection

Inflammation, Immune Activation, and Antiretroviral Therapy in HIV

Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions

Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease

Interferon-alpha administration enhances CD8+ T cell activation in HIV infection

Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers

Lipid Abnormalities and Inflammation in HIV Inflection

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis.

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms

Markers of coagulation and inflammation often remain elevated in ART-treated HIV-infected patients

Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals.

Membrane damage and repair in primary monocytes exposed to human β-defensin-3

Microbial translocation, immune activation, and HIV disease

Oxidized LDL Levels Are Increased in HIV Infection and May Drive Monocyte Activation.

Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy

Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections

Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+ individuals.

Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV.

Rosuvastatin Decreases Intestinal Fatty Acid Binding Protein (I-FABP), but Does Not Alter Zonulin or Lipopolysaccharide Binding Protein (LBP) Levels, in HIV-Infected Subjects on Antiretroviral Therapy

Rosuvastatin preserves renal function and lowers cystatin C in HIV-infected subjects on antiretroviral therapy: the SATURN-HIV trial

Rosuvastatin reduces vascular inflammation and T-cell and monocyte activation in HIV-infected subjects on antiretroviral therapy

Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy ⬇️

SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.

Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome

Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection

Soluble TWEAK may predict carotid atherosclerosis in treated HIV infection.

Soluble Urokinase Plasminogen Activator Receptor Is Predictive of Non-AIDS Events During Antiretroviral Therapy-mediated Viral Suppression

Statin Therapy Does Not Reduce Liver Fat Scores in Patients Receiving Antiretroviral Therapy for HIV Infection

Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects

The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes ⬇️

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial

Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis

Transcriptional Profiling Identifies Mechanisms Associated With Platelet Activation in HIV Infection

Treatment of HIV infection with a raltegravir-based regimen increases LDL levels, but improves HDL cholesterol efflux capacity.