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List of works by Levon Khachigian

"Summer Shift": A Potential Effect of Sunshine on the Time Onset of ST-Elevation Acute Myocardial Infarction

scientific article published on 6 April 2018

A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine.

scientific article published on July 1991

A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.

scientific article

A monopartite sequence is essential for p45 NF‐E2 nuclear translocation, transcriptional activity and platelet production ⬇️

scientific article published on November 1, 2010

A novel model of in-stent restenosis: rat aortic stenting.

scientific article

A promoter-level mammalian expression atlas

scientific article

Activation transcription factor-4 and the acute vascular response to injury.

scientific article published on 21 March 2010

Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury

scientific journal article

Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction ⬇️

scientific article published on April 22, 2013

Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis.

scientific article published on 9 June 2010

Angiotensin II (ATII)-inducible platelet-derived growth factor A-chain gene expression is p42/44 extracellular signal-regulated kinase-1/2 and Egr-1-dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII antagonized by

scientific article published on 01 August 1999

Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.

scientific article published on 13 February 2008

Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1

scientific article

Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement

scientific journal article

BT2 Suppresses Human Monocytic-Endothelial Cell Adhesion, Bone Erosion and Inflammation

scientific article published on 23 March 2021

Beyond angioplasty: novel developments in interventional cardiology.

scientific article published in September 2002

Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

scientific article published on 01 September 2008

Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.

scientific article published on 23 August 2007

Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function.

scientific article

Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis

scientific article published on 01 October 2001

Collagen antibody-induced arthritis

scientific article published on 01 January 2006

Comparative transcriptomics of primary cells in vertebrates

scientific article published on 27 July 2020

Coronary in-stent restenosis: current status and future strategies.

scientific article

Corrigendum to "The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting" [Atherosclerosis 194 (2) (2007) 364-371]

scientific article published on 01 June 2017

Corrigendum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

scientific article published on 01 August 2015

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer ⬇️

scientific article published on September 1, 2013

Current and Potential Treatments for Cervical Cancer ⬇️

scientific article published on February 1, 2013

DNAzyme Delivery Approaches in Biological Settings ⬇️

scientific article published on January 1, 2013

DNAzyme targeting c-jun suppresses skin cancer growth.

scientific article

DNAzyme technology and cancer therapy: cleave and let die.

scientific article published on February 2008

DNAzymes and cardiovascular disease.

scientific article published on 05 May 2008

DNAzymes and their therapeutic possibilities.

scientific article published on April 2009

DNAzymes as molecular agents that manipulate Egr-1 gene expression.

scientific article published in September 2004

Deoxyribozymes as inhibitors of vascular smooth muscle cell growth.

scientific article published in August 2004

Destroyingc-junMessenger: New Insights into Biological Mechanisms of DNAzyme Function ⬇️

scientific article published on June 1, 2012

Developing Neolignans as Proangiogenic Agents: Stereoselective Total Syntheses and Preliminary Biological Evaluations of the Four Guaiacylglycerol 8-O-4'-Coniferyl Ethers

scientific article

Divergent roles of NF-κB and Egr-1 in flow-dependent restenosis after angioplasty and stenting.

scientific article

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

article

Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model.

scientific article

Drug-induced immune thrombocytopenia

scientific article published on 09 April 2013

Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG.

scientific article

EGFR and the Complexity of Receptor Crosstalk in the Cardiovascular System

scientific article published on January 1, 2013

ERK, JNK, and p38 MAP kinases differentially regulate proliferation and migration of phenotypically distinct smooth muscle cell subtypes ⬇️

scientific article published on May 15, 2003

Early growth response factor 1: a pleiotropic mediator of inducible gene expression

scientific article published on 01 August 1998

Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2

scientific article published on March 1999

Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.

scientific article

Early growth response-1 in the pathogenesis of cardiovascular disease.

scientific article published on June 2016

Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation.

scientific article

Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter

scientific article published on 01 October 1997

Egr-1-induced endothelial gene expression: a common theme in vascular injury

scientific article published on 01 March 1996

Emerging therapeutic approaches in the management of retinal angiogenesis and edema.

scientific article published on 18 December 2010

Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.

scientific article

Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting [...]

scientific journal article

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1

scientific article published on 01 August 1997

Fibroblast Growth Factor-2 Represses Platelet-derived Growth Factor Receptor-α (PDGFR-α) Transcription via ERK1/2-dependent Sp1 Phosphorylation and an Atypical cis-Acting Element in the Proximal PDGFR-α Promoter ⬇️

scientific article published on October 30, 2003

Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.

scientific article

GILZ Overexpression Inhibits Endothelial Cell Adhesive Function through Regulation of NF-κB and MAPK Activity ⬇️

scientific article published on May 31, 2013

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

scientific article published on 16 August 2005

Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation.

scientific article

Hemodynamics, endothelial gene expression, and atherogenesis.

scientific article published on April 1997

In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1+/CD31+ side-population cells).

scientific article

Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1

scientific journal article

Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide

scientific article published on 30 June 2016

Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter.

scientific article published on 31 July 2009

Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.

scientific article published on 17 February 2012

Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy

scientific article

Isolation and Characterization of a Novel Zinc-finger Protein with Transcriptional Repressor Activity ⬇️

scientific article published on September 22, 1995

JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation

scientific journal article

Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.

scientific article

Melanoma protective antitumor immunity activated by catalytic DNA

scientific article published on 29 May 2018

MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury

scientific article published on 16 March 2016

Modulation of growth factor gene expression in vascular cells by oxidative stress.

scientific article published in March 2004

New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

scientific article published on 01 November 1999

Novel and emerging therapies in cardiology and haematology

scientific article (publication date: June 2003)

Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression.

scientific article published on April 2000

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

scientific article published on August 1995

Nuclear factor-kappa B mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells.

scientific article published on January 1995

Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.

scientific article published on 17 March 2011

Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.

scientific article

Overstretch stent injury to the rat aorta leads to in-stent restenosis

scientific article published on 01 April 2002

PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.

scientific article published on 7 July 2010

PDGF-D expression is down-regulated by TGFβ in fibroblasts

scientific article

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

scientific article

Platelet-derived Growth Factor and its Receptor: Structure and Roles in Normal Growth and Pathology

scientific article published on 01 January 1993

Platelet-derived growth factor and alternative splicing: a review

scientific article published on October 1, 1992

Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway

scientific article

Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C.

scientific article

Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β

scientific article published in Scientific Reports

Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding

scientific article

Rat aortic stenting: toward a simple model of in-stent restenosis

scientific article published on 01 September 2001

Rat models of myocardial infarction. Pathogenetic insights and clinical relevance

scientific article published on 01 November 2006

Recent advances in vascular biology: selected highlights from IVBM 2008

scientific article published on 01 June 2009

Recent developments in drug-eluting stents ⬇️

scientific article published on January 29, 2011

Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1

scientific article published in Journal of Biological Chemistry

Regulation of PDGF-B in endothelial cells exposed to cyclic strain

scientific article published on 01 March 1998

Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.

scientific article published on 5 September 2013

Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation.

scientific article published on 26 April 2014

Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells.

scientific article published on 29 January 2009

Remote Ischemic Preconditioning induces Cardioprotective Autophagy and Signals through the IL-6-Dependent JAK-STAT Pathway

scientific article published on 01 March 2020

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.

scientific article

Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)

scientific article

Signaling and transcriptional control of Fas ligand gene expression.

scientific article

Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation.

scientific article

Sp1 phosphorylation and its regulation of gene transcription.

scientific article published on 09 March 2009

Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration.

scientific article published in August 2012

Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6

scientific article published on 01 January 1994

Succinobucol induces apoptosis in vascular smooth muscle cells

scientific article published on 21 December 2011

Suppressing a sick heart

scientific article published on 01 August 2005

Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun.

scientific article published on 2 July 2006

TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner

scientific article

TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor

scientific article published on 3 January 2008

Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.

scientific article

The Yin and Yang of YY1 in tumor growth and suppression.

scientific article published on 11 January 2018

The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting.

scientific article published on 27 December 2006

The streptozotocin-treated Sprague-Dawley rat: a useful model for the assessment of acute and chronic effects of myocardial ischaemia reperfusion injury in experimental diabetes

scientific article published on 01 June 2007

Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis

scientific article published on 29 July 2020

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

scientific article

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

scientific article published on 20 July 2003

Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response

scientific article

Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent.

scientific article published on September 1999

Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21(WAF1/Cip1) promoter.

scientific article published on November 2004

Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury

scientific article published on October 1999

Vessel wall apoptosis and atherosclerotic plaque instability.

scientific article

Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly.

scientific article published on 7 June 2007

Zinc Finger Transcription Factors Mediate High Constitutive Platelet-derived Growth Factor-B Expression in Smooth Muscle Cells Derived from Aortae of Newborn Rats ⬇️

scientific article published on March 6, 1998

c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

scientific article

c-Jun knockdown sensitizes osteosarcoma to doxorubicin.

scientific article published in July 2008

c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.

scientific article

c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun

scientific article published on 12 March 2002

von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter

scientific article published on 01 January 2002

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