List of works by Manuel Benito

Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.

scientific article published on July 1999

Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture

scientific article

Alterations in the Insulin Signaling Pathway Induced by Immortalization and H-ras Transformation of Brown Adipocytes* ⬇️

scientific article published on August 1, 1997

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage.

scientific article

Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary Cultures

scientific article published in Journal of Biological Chemistry

Apoptotic Response to TGF-$beta; in Fetal Hepatocytes Depends upon Their State of Differentiation

scientific article published on 01 November 1999

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

scientific article published on April 2001

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform

scientific article published on 9 January 2009

Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer

scientific article published on 01 January 2007

Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction.

scientific article

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

scientific article

Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism

scientific article published on 01 March 1996

Changes in the liver lactate dehydrogenase isozyme profile after induced glycogenolysis

scientific article published on 01 April 1978

Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer

scientific article published in January 2005

Comparative Survival Analysis of p53 Gene Mutations and Protein Accumulation in Colorectal Cancer

scientific article published in 1998

Cooperative role of telomerase activity and p16 expression in the prognosis of non-small-cell lung cancer

scientific article published on 01 January 2002

Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma

scientific article published in February 2006

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture.

scientific article published on October 1997

Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression

scientific article published on 01 March 2000

Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability

scientific article published on 01 February 2008

Differential colorectal carcinogenesis: Molecular basis and clinical relevance

scientific article

Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications

scientific article published in February 2004

Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer

scientific article published on 01 November 1999

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones

scientific article published on 01 October 1992

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

scientific article

Effect of glucose administration on rat liver glycogenolysis after birth

scientific article published on 01 October 1980

Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period

scientific article published on 01 January 1983

Eight novel germlineMLH1andMSH2mutations in hereditary non-polyposis colorectal cancer families from Spain

scientific article published on 13 November 2001

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

scientific article published on 01 September 2000

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture

article

Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.

scientific article

Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status

scientific article published on 30 September 2019

Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma

scientific article published on 01 January 2007

Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture.

scientific article published in February 2000

Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors.

scientific article published in May 2002

Glucocorticoid receptor down-Regulates c-jun amino terminal kinases induced by tumor necrosis factor ? in fetal rat hepatocyte primary cultures

article

Glucose-6-phosphate dehydrogenase gene expression in fetal hepatocyte primary cultures under nonproliferative and proliferative conditions

scientific article published on 01 January 1994

Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor: modulation of c-myc and c-fos expression

scientific article published on December 15, 1992

Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture

scientific journal article

Hormonal regulation of malic enzyme and glucose-6-phosphate-dehydrogenase expression in fetal brown-adipocyte primary cultures under non-proliferative conditions

scientific article published on 01 January 1992

Hormonal regulation of malic enzyme expression in primary cultures of foetal brown adipocytes

article

IGF-I induces the uncoupling protein gene expression in fetal rat brown adipocyte primary cultures: role of C/EBP transcription factors.

scientific article

IGF-I: a mitogen also involved in differentiation processes in mammalian cells

scientific article

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

scientific article published in December 2004

Initial expression of phosphoenolpyruvate carboxykinase gene in fetal hepatocytes: role of transcription factors

scientific article published on 01 October 1996

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner. ⬇️

scientific article published on February 1999

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

scientific article

Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling

scientific article

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes

scientific article published on 13 January 2003

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

scientific article published on October 1996

Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat ⬇️

scientific article published on August 15, 1981

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

scientific article published on 07 February 2019

Long-term effect of glucagon administration on rat liver L-type pyruvate kinase

scientific article published on 01 January 1979

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

scientific article published on 18 September 2003

Loss of heterozygosity at 3p23 is correlated with poor survival in patients with colorectal carcinoma

scientific article published on 01 September 2000

MMP-7 and SGCE as distinctive molecular factors in sporadic colorectal cancers from the mutator phenotype pathway.

scientific article published on May 2010

Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis.

scientific article

Methylation profiling in non-small cell lung cancer: clinical implications

scientific article published on 07 November 2011

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

scientific article published in September 2003

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1

scientific article published on 14 July 2006

New mutation in the hMSH2 gene in a Spanish Muir-Torre syndrome

scientific article published on 01 September 2000

Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture

article

Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action

scientific article

Occurence of α2-adrenergic effects on adenylate cyclase activity and (3H)- clonidine specific binding in brown adipose tissue from foetal rats

scientific article published on 01 August 1986

Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner

scientific article published on 01 April 2000

Operation of the glucose-fatty acid cycle after glycogenolysis induced by treatment with nicotinic acid ⬇️

scientific article published on May 1, 1978

Overexpression of c-myc and loss of heterozygosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma

scientific article published on 01 March 2005

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

scientific article published on 14 November 2003

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

scientific article published on 5 June 2008

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics.

scientific article

Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes

scientific article published on 01 May 1997

Phosphoenolpyruvate carboxykinase and glucose-6-phosphate dehydrogenase expression in fetal hepatocyte primary cultures under proliferative conditions

scientific article published on 01 June 1992

Precocious induction of malic enzyme by nutritional and hormonal factors in rat foetal hepatocyte primary cultures

article

Prematurity in the rat. II. Effect of hypothermia

scientific article published on 01 January 1980

Preparation of hormone-sensitive adipocytes from foetal rat brown adipose tissue

scientific article published on 01 May 1984

Prevalence of germline mutations ofMLH1 andMSH2 in hereditary nonpolyposis colorectal cancer families from Spain

article

Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.

scientific article

Prevalent role of the insulin receptor isoform A in the regulation of hepatic glycogen metabolism in hepatocytes and in mice.

scientific article published on 7 September 2016

Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung.

scientific article

Prognostic value of genomic damage in non-small-cell lung cancer.

scientific article

Proliferation of fetal brown adipocyte primary cultures: relationship with the genetic expression of glucose 6 phosphate dehydrogenase

scientific article published on 01 June 1991

Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process

scientific article published on 10 June 2015

Pyruvate kinase activity and gluconeogenesis in rat liver after glycogen depletion with nicotinic acid

scientific article published on 01 November 1976

Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines

scientific article published on 01 November 1996

Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects

scientific article published in August 1989

Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

scientific article published in March 2001

Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones

scientific article published on July 1, 1992

Regulation of carnitine palmitoyltransferase activity in the liver and brown adipose tissue in the newborn rat: effect of starvation and hypothermia.

scientific article published in March 1986

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: Role of epidermal growth factor and dexamethasone

article

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone

scientific article published on 01 December 1995

Regulation of glycogenolysis in the liver of the newborn rat in vivo. Inhibitory effect of glucose

scientific article published on 01 February 1981

Regulation of ketogenesis during the suckling–weanling transition in the rat. Studies with isolated hepatocytes

scientific article published on April 15, 1979

Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation ⬇️

scientific article published on December 15, 1983

Regulation of malic enzyme gene expression by nutrients, hormones, and growth factors in fetal hepatocyte primary cultures

scientific article published on 01 April 1993

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

scientific article published on 27 August 2003

Role of brown and perivascular adipose tissue in vascular complications due to obesity

scientific article published on 11 January 2013

Role of prolactin on the regulation of hepatic lipogenesis in vivo during late gestation in the rat

scientific article published on 01 November 1982

Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.

scientific article

Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

scientific article published on 31 October 2002

Severe Brown Fat Lipoatrophy Aggravates Atherosclerotic Process in Male Mice.

scientific article published on 14 July 2016

Stimulation of ketogénesis after glycogen depletion by nicotinic acid in perfused rat liver

scientific article published on 01 March 1978

Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors

scientific article published in July 2002

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

scientific article published on 08 September 2004

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture

scientific article published on 01 October 1997

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK

scientific article published on 01 March 2001

TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.

scientific article published on 16 August 2016

Telomere function in colorectal cancer.

scientific article published on October 2009

Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer.

scientific article published on 20 February 2008

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

scientific article

The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance.

scientific article

The effect of chronic ethanol administration on lipogenesis in liver and adipose tissue in the rat

scientific article published on 01 November 1983

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes

scientific article published on 01 November 2002

Tissue specificity on insulin action and resistance: past to recent mechanisms.

scientific article published on March 2011

Tissue-specificity of insulin action and resistance.

scientific article published on 20 April 2011

Transforming growth factor ? modulates growth and differentiation of fetal hepatocytes in primary culture

scientific article published on 01 November 1995

Transforming growth factor beta 1 induces differentiation-specific gene expression in fetal rat brown adipocytes

scientific article published on 01 May 1995

Transforming growth factor beta 1 induces mitogenesis in fetal rat brown adipocytes

scientific article published on 01 March 1996

Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture.

scientific article

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes

scientific article

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression

scientific article published on 01 March 1994

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes

scientific article published on 01 March 1998

[In vivo study of lipogenesis and glycogen synthesis in fetal tissues of the rat. Effect of dexamethasone]

scientific article published on 01 January 1982

[Profile of the capacity for lipid synthesis in vivo in various rat tissues: effect of age]

scientific article published on 01 January 1982

[Role of white adipose tissue in vascular complications due to obesity]

scientific article published on 05 January 2013

beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes

scientific article published on 01 December 1999

cAMP inhibits IGF-I-induced mitogenesis in fetal rat brown adipocytes: role of p21 ras

scientific article published on 01 May 1995

cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes

scientific article

p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes

scientific article published on 01 December 2000

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.

scientific article published on 16 July 2007

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer ⬇️

scientific article published on January 1, 1997

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