List of works - Costas Koumenis

"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

scientific article published on July 2006

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

scientific article published on 23 December 2016

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

scientific article

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

scientific article published on 02 June 2022

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment

scientific article published on 28 March 2016

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

scientific article published on 01 July 2019

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

scientific article published on May 2009

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

scientific article

Activating transcription factor 4 is translationally regulated by hypoxic stress

scientific article published on September 2004

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

scientific article published on 01 August 2019

Avoiding antiperspirants during breast radiation therapy: Myth or sound advice?

scientific article published on 18 July 2017

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

scientific article published on 25 April 2015

Control of the hypoxic response through regulation of mRNA translation.

scientific article

Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.

scientific article published on February 2002

Current Delivery Limitations of Proton PBS for FLASH

scientific article published on 10 November 2020

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

scientific article published on 01 February 2020

Development of a stress response therapy targeting aggressive prostate cancer.

scientific article published in May 2018

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

scientific article

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

scientific article

ER stress, hypoxia tolerance and tumor progression.

scientific article

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

Effects of radiation quality and oxygen on clustered DNA lesions and cell death.

scientific article

Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia.

scientific article

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

scientific article

Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance. ⬇️

scientific article published on 21 November 2016

Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

scientific article published on December 2011

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

scientific article

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

scientific article

HIF and MIF--a nifty way to delay senescence?

scientific article published on 01 December 2006

HIF-1alpha and p53: the ODD couple?

scientific article

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.

scientific article published on 15 July 2011

Hypoxia and the unfolded protein response.

scientific article published on January 2007

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

scientific article

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

scientific article

Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system

scientific article published on 01 June 1995

In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.

scientific article

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

scientific article

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

scientific article published in February 2017

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor

scientific article

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

scientific article

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

scientific article published on February 2007

Location, location, location-makes all the difference for hypoxia in lung tumors.

scientific article published on 21 September 2010

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

scientific article published on 22 June 2011

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

scientific article

PERK-ing up autophagy during MYC-induced tumorigenesis.

scientific article published on 17 January 2013

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

scientific article

Piling up the JNK: drug synergy through ER stress.

scientific article

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

scientific article published on November 2008

Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

scientific article published on 6 September 2017

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

scientific article

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

scientific article

Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo

scientific article

Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor

scientific article

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

scientific article published on 30 June 2015

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

scientific article published on 24 March 2016

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

scientific article

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

scientific article

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

scientific article published on 24 February 2014

Targeting hypoxia tolerance in cancer

scientific article published on February 2004

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

scientific article

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

scientific article published on 14 May 2010

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

scientific article

The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.

scientific article published on 15 December 2006

The cell biology of the unfolded protein response.

scientific article

The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.

scientific article published on May 2012

The heat shock proteins as targets for radiosensitization and chemosensitization in cancer ⬇️

scientific article published on December 15, 2011

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.

scientific article published on April 2010

The use of a reversible transcription inhibitor, DRB, to investigate the involvement of specific proteins in the ocular circadian system of Aplysia

scientific article published on 01 March 1996

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells

scientific article

Transformed Cells Require Continuous Activity Of RNA Polymerase II To Resist Oncogene-Induced Apoptosis ⬇️

scientific article published on December 1, 1997

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

scientific article

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

scientific article published on 01 February 2020

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

scientific article published on 4 April 2016

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

scientific article

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

scientific article published on 13 May 2016

p27Kip1 is essential for the antiproliferative action of 1,25-dihydroxyvitamin D3 in primary, but not immortalized, mouse embryonic fibroblasts.

scientific article published on 5 August 2002

List of works by Costas Koumenis

"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

Activating transcription factor 4 is translationally regulated by hypoxic stress

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Avoiding antiperspirants during breast radiation therapy: Myth or sound advice?

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

Control of the hypoxic response through regulation of mRNA translation.

Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.

Current Delivery Limitations of Proton PBS for FLASH

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

Development of a stress response therapy targeting aggressive prostate cancer.

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

ER stress, hypoxia tolerance and tumor progression.

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Effects of radiation quality and oxygen on clustered DNA lesions and cell death.

Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia.

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance. ⬇️

Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

HIF and MIF--a nifty way to delay senescence?

HIF-1alpha and p53: the ODD couple?

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.

Hypoxia and the unfolded protein response.

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system

In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

Location, location, location-makes all the difference for hypoxia in lung tumors.

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

PERK-ing up autophagy during MYC-induced tumorigenesis.

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

Piling up the JNK: drug synergy through ER stress.

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo

Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

Targeting hypoxia tolerance in cancer

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.

The cell biology of the unfolded protein response.

The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.

The heat shock proteins as targets for radiosensitization and chemosensitization in cancer ⬇️

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.

The use of a reversible transcription inhibitor, DRB, to investigate the involvement of specific proteins in the ocular circadian system of Aplysia

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells

Transformed Cells Require Continuous Activity Of RNA Polymerase II To Resist Oncogene-Induced Apoptosis ⬇️

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

p27Kip1 is essential for the antiproliferative action of 1,25-dihydroxyvitamin D3 in primary, but not immortalized, mouse embryonic fibroblasts.