List of works - Ke Ruan

A Novel Inhibitor of the New Antibiotic Resistance (ARE) Protein OptrA.

scientific article published on 19 April 2018

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

scientific article published on 17 August 2018

Application of Hadamard spectroscopy to automated structure verification in high-throughput NMR

scientific article published on 01 August 2009

Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex

scientific article (publication date: 2014)

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

scientific article published on 14 June 2019

Composite alignment media for the measurement of independent sets of NMR residual dipolar couplings.

scientific article published in November 2005

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe

scientific article published on 25 September 2020

Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer

scientific article published on 22 March 2016

Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy

scientific article published on 06 July 2018

Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment

scientific article published in Journal of Biological Chemistry

Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange.

scientific article

Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange

scientific article published on 07 June 2018

Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

scientific article published on 6 October 2017

Multiple alignment tensors from a denatured protein

scientific article published on 01 July 2006

NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains

scientific article

NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43

scientific article published on 30 June 2019

NMR characterization of weak interactions between RhoGDI2 and fragment screening hits

scientific article published on 6 October 2016

Process of Fragment-Based Lead Discovery-A Perspective from NMR

scientific article

Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification

scientific article

Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.

scientific article

Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac

scientific article

Structural insight into the unique dsDNA binding topology of the human ORC2 wing helix domain

scientific article published on 19 April 2019

Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.

scientific article published on 12 April 2018

Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase

scientific article

The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.

scientific article

List of works by Ke Ruan

A Novel Inhibitor of the New Antibiotic Resistance (ARE) Protein OptrA.

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

Application of Hadamard spectroscopy to automated structure verification in high-throughput NMR

Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

Composite alignment media for the measurement of independent sets of NMR residual dipolar couplings.

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe

Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer

Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy

Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment

Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange.

Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange

Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

Multiple alignment tensors from a denatured protein

NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains

NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43

NMR characterization of weak interactions between RhoGDI2 and fragment screening hits

Process of Fragment-Based Lead Discovery-A Perspective from NMR

Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification

Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.

Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac

Structural insight into the unique dsDNA binding topology of the human ORC2 wing helix domain

Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.

Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase

The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.