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List of works by Akimitsu Okamoto

2-Oxazoline formation for selective chemical labeling of 5-hydroxylysine

scientific article published on 20 March 2015

5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

scientific article published on 15 September 2011

5-methylcytosine-selective osmium oxidation.

scientific article published in January 2007

A Light-Inducible Hedgehog Signaling Activator Modulates Proliferation and Differentiation of Neural Cells

scientific article published on 28 April 2020

A dielectric-sensitive fluorescent DNA probe for monitoring polarities on the interior of a DNA-binding protein.

scientific article published in September 2005

A highly constrained nucleic acid analog based on α-l-threosamine

scientific article published on 17 September 2019

A nucleic acid probe labeled with desmethyl thiazole orange: a new type of hybridization-sensitive fluorescent oligonucleotide for live-cell RNA imaging

scientific article published on 22 November 2012

A nucleobase that releases reporter tags upon DNA oxidation.

scientific article

A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes.

scientific article published on 18 November 2011

Application of caged fluorescent nucleotides to live-cell RNA imaging

scientific article published on 01 January 2013

Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate

scientific article published on 24 October 2016

Base-discriminating fluorescent (BDF) nucleoside: distinction of thymine by fluorescence quenching.

scientific article

Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications

scientific article published in 2022

Characterization of the triplet state of hybridization-sensitive DNA probe by using fluorescence correlation spectroscopy

scientific article published on 21 December 2012

Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes

scientific article published on 27 September 2019

Chemical approach toward efficient DNA methylation analysis.

scientific article

Chemical synthesis of dual labeled proteins via differently protected alkynes enables intramolecular FRET analysis.

scientific article published on 17 May 2017

Chemically Activatable Alkyne Tag for Low pH-Enhanced Molecular Labeling on Living Cells

scientific article published on 15 August 2016

Chemically-activatable alkyne-tagged probe for imaging microdomains in lipid bilayer membranes

scientific article

Chemistry-Driven Epigenetic Investigation of Histone and DNA Modifications

scientific article published on 02 August 2018

Clear distinction of purine bases on the complementary strand by a fluorescence change of a novel fluorescent nucleoside.

scientific article published in April 2003

Cy5-conjugated hybridization-sensitive fluorescent oligonucleotides for ratiometric analysis of nuclear poly(A)+ RNA.

scientific article published on 20 July 2011

Cysteinylprolyl imide (CPI) peptide: a highly reactive and easily accessible crypto-thioester for chemical protein synthesis

scientific article published on 09 May 2019

Cytosine detection by a fluorescein-labeled probe containing base-discriminating fluorescent nucleobase.

scientific article published in July 2004

DNA hole transport on an electrode: application to effective photoelectrochemical SNP typing.

scientific article published in January 2006

DNA logic gates.

scientific article

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation

scientific article published on 11 May 2017

DNA-osmium complexes: recent developments in the operative chemical analysis of DNA epigenetic modifications.

scientific article published on 02 July 2014

Degradation of DNA by bisulfite treatment

scientific article published on 24 January 2007

Design and synthesis of caged fluorescent nucleotides and application to live-cell RNA imaging

scientific article published on 28 October 2011

Design of base-discriminating fluorescent nucleoside and its application to t/c SNP typing.

scientific article published in August 2003

Diazirine photocrosslinking recruits activated FTO demethylase complexes for specific N(6)-methyladenosine recognition

scientific article published on 16 March 2015

Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide

scientific article published on 21 June 2011

ECHO probes: a concept of fluorescence control for practical nucleic acid sensing.

scientific article published on 10 June 2011

ECHO-LNA conjugates: hybridization-sensitive fluorescence and its application to fluorescent detection of various RNA strands

scientific article published on 19 November 2010

ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.

scientific article

Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection.

scientific article published on 12 April 2018

Emission control by binary energy transfer processes on oligouridine

scientific article published on 12 August 2011

Exciton Primer-mediated SNP detection in SmartAmp2 reactions.

scientific article published in February 2010

Exciton-controlled hybridization-sensitive fluorescent probes: multicolor detection of nucleic acids

scientific article published on 01 January 2009

Excitonic interaction: another photophysical process for fluorescence-controlled nucleic acid sensing.

scientific article published in June 2010

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

scientific article

Facile synthesis of hydroxymethylcytosine-containing oligonucleotides and their reactivity upon osmium oxidation

scientific article published on 15 April 2011

Fluorescence-switching RNA for detection of bacterial ribosomes.

scientific article

Fluorescent triplex-forming DNA oligonucleotides labeled with a thiazole orange dimer unit.

scientific article

Fluorometric sensing of the salt-induced B-Z DNA transition by combination of two pyrene-labeled nucleobases.

scientific article

Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide

scientific article published on 02 June 2020

Hybridization-sensitive fluorescence control in the near-infrared wavelength range

scientific article published on 15 April 2011

Hybridization-sensitive fluorescent DNA probe with self-avoidance ability.

scientific article published on 7 December 2009

Hybridization-sensitive fluorescent oligonucleotide probe conjugated with a bulky module for compartment-specific mRNA monitoring in a living cell.

scientific article

Hybridization-sensitive fluorescent probe for long-term monitoring of intracellular RNA

scientific article published on 01 June 2009

Hydroxyapatite: catalyst for a one-pot pentose formation.

scientific article

ICON probes: synthesis and DNA methylation typing.

scientific article published in December 2011

In vitro and in cell analysis of chemically synthesized histone H2A with multiple modifications

scientific article published on 01 April 2016

Intracellular mRNA imaging with a hybridization sensitive fluorescent nucleotide.

scientific article

L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells

scientific article published on 01 October 2020

Ligand-incorporation site in 5-methylcytosine-detection probe modulating the site of osmium complexation with the target DNA

scientific article published on 01 September 2012

Live-Cell Sensing of Telomerase Activity by Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes

scientific article published on 16 December 2019

Methylcytosine-selective fluorescence quenching by osmium complexation

scientific article published on 15 December 2006

Microfluidic preparation of anchored cell membrane sheets for in vitro analyses and manipulation of the cytoplasmic face.

scientific article

Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle: Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM Bindin

scientific article

Modulation of base selectivity for a base-discriminating fluorescent nucleobase by addition of mercury ion.

scientific article published in October 2005

Modulation of remote DNA oxidation by hybridization with peptide nucleic acids (PNA).

scientific article published in March 2002

Monitoring DNA structures by dual fluorescence of pyrene derivatives.

scientific article published in September 2005

Nile Red nucleoside: design of a solvatofluorochromic nucleoside as an indicator of micropolarity around DNA.

scientific article published in April 2006

Oligonucleotides containing 7-vinyl-7-deazaguanine as a facile strategy for expanding the functional diversity of DNA.

scientific article

On-chip DNA methylation analysis using osmium complexation.

scientific article published on 15 May 2011

Osmium Tag for Post-transcriptionally Modified RNA

scientific article published on 26 June 2018

Osmium complex binding to mismatched methylcytosine: effect of adjacent bases.

scientific article published in January 2009

P-loop catalytically assisting the enzymatic cleavage of single-stranded DNA.

scientific article

PRODAN-conjugated DNA: synthesis and photochemical properties

scientific article published on 23 March 2007

Phosphopeptides designed for 5-methylcytosine recognition

scientific article published on 31 March 2011

Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells

scientific article published on 11 October 2019

Photostimulated hole transport through a DNA duplex immobilized on a gold electrode.

scientific article published in November 2004

Probe design for the effective fluorescence imaging of intracellular RNA.

scientific article published on 13 March 2013

Public-key system using DNA as a one-way function for key distribution.

scientific article published on 25 February 2005

Rapid nuclear import of short nucleic acids

scientific article published on 27 August 2016

Rational design of a DNA wire possessing an extremely high hole transport ability.

scientific article published in April 2003

Reactivity of thymine doublet in single strand DNA with osmium reagent.

scientific article

Regulation of the Stability of the Histone H2A-H2B Dimer by H2A Tyr57 Phosphorylation.

scientific article published on 16 August 2017

Sequence dependence of fluorescence emission and quenching of doubly thiazole orange labeled DNA: effective design of a hybridization-sensitive probe.

scientific article published on 31 July 2008

Sequence-selective osmium oxidation of DNA: efficient distinction between 5-methylcytosine and cytosine.

scientific article

Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes.

scientific article published on 28 August 2013

Sets of RNA repeated tags and hybridization-sensitive fluorescent probes for distinct images of RNA in a living cell

scientific article

Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold

scientific article published on 07 February 2019

Site-selective DNA alkylation of GG steps by naphthaldiimide derivatives possessing enantiomeric epoxide

scientific article published on 01 October 2000

Site-specific discrimination of Cytosine and 5-methylcytosine in duplex DNA by Peptide nucleic acids.

scientific article published in September 2002

Specific Alkylation of Guanine Opposite to a Single Nucleotide Bulge: A Chemical Probe for the Bulged Structure of DNA

scientific article published on 01 November 1999

Stable, specific, and reversible base pairing via Schiff base.

scientific article published in November 2005

Synthesis and properties of peptide nucleic acids containing a psoralen unit.

scientific article

Synthesis of exciton-controlled fluorescent probes for RNA imaging.

scientific article published in January 2009

Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation

article

Unique hole-trapping property of the degenerate base,2-amino-7-deazaadenine.

scientific article published in December 2002

Visualization of nucleic acids with synthetic exciton-controlled fluorescent oligonucleotide probes.

scientific article

Whole-mount MeFISH: a novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression

scientific article

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