List of works - Stephen D Ginsberg

A genotype resource for postmortem brain samples from the Autism Tissue Program

scientific article

Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains.

scientific article published in August 1999

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

scientific article published on 10 July 2009

Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.

scientific article

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

scientific article

Amplification of RNA transcripts using terminal continuation.

scientific article

An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain.

scientific article published in December 2002

Apolipoprotein E4 genotype compromises brain exosome production

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome

scientific article published on 30 December 2015

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.

scientific article published on April 2016

Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology

scientific article published on 23 July 2019

CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation (MCS).

scientific article published on 2 February 2018

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

scientific article published on 29 July 2015

Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

scientific article published on 29 November 2019

Characterization of the putative cholesterol transport protein metastatic lymph node 64 in the brain

scientific article

Cholinotrophic molecular substrates of mild cognitive impairment in the elderly.

scientific article published on September 2007

Circulating Aβ40 influences plasma BDNF levels and white matter integrity

Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampus.

scientific article

Combining online and in-person methods to evaluate the content validity of PROMIS fatigue short forms in rheumatoid arthritis

article

Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.

scientific article

Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy.

scientific article

Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

scientific article

Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the rat.

scientific article

Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression.

scientific article

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.

scientific article

Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome

scientific article published on 20 September 2015

Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression

scientific article published on 15 July 2021

Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation.

scientific article published in August 1993

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

scientific article published on 29 August 2017

Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice

scientific article published in 2022

Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).

scientific article

Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice

scientific article

Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons

scientific article published on 01 July 2000

Expression profiling and pharmacotherapeutic development in the central nervous system.

scientific article

Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder

scientific article published on 8 October 2011

Expression profiling in the aging brain: a perspective.

scientific article

Expression profiling suggests microglial impairment in HIV neuropathogenesis.

scientific article published on 25 January 2018

Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis.

scientific article

Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.

scientific article published in January 1999

Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus.

scientific article published in September 1996

Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

scientific article published on 07 February 2019

Functional genomic methodologies.

scientific article published on January 2006

Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease.

scientific article

Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease.

scientific article published on 12 January 2006

Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease.

scientific article

Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study

scientific article published on 16 January 2018

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

scientific article

Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.

scientific article published on October 2002

Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome.

scientific article published on April 2014

Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology

scientific article

Hippocampal plasticity during the progression of Alzheimer's disease

scientific article

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

scientific article published on December 2003

Identification of CSPα clients reveals a role in dynamin 1 regulation.

scientific article published in April 2012

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

scientific article published on 03 January 2008

Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients

scientific article published on 30 May 2016

Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

scientific article published on 10 June 2019

Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome

scientific article published on 09 June 2019

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.

scientific article published on 20 September 2015

Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.

scientific article published on April 2014

Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

scientific article

Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice

scientific article

Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice

scientific article

Measurement of myelin basic protein and of anti-basic protein antibodies by ELISA utilizing biotinylated antibodies

scientific article published on 01 January 1983

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

scientific article (publication date: 2012)

Methods and compositions for amplification and detection of microRNAs (miRNAs) and noncoding RNAs (ncRNAs) using the signature sequence amplification method (SSAM).

scientific article

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.

scientific article

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

scientific article

Mild cognitive impairment: pathology and mechanisms.

scientific article

Mitotic Figures in the Median Eminence of the Hypothalamus ⬇️

scientific article published on August 1, 2010

Molecular and cellular pathophysiology of preclinical Alzheimer's disease

scientific article published on 13 May 2016

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease

scientific article published on 01 July 2019

Neuron-specific age-related decreases in dopamine receptor subtype mRNAs

scientific article (publication date: 3 February 2003)

Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.

scientific article published on 10 December 2015

Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease.

scientific article published on January 2006

Non-NMDA glutamate receptors are present throughout the primate hypothalamus

scientific article published on 01 March 1995

Noradrenergic innervation of the hypothalamus of rhesus monkeys: distribution of dopamine-beta-hydroxylase immunoreactive fibers and quantitative analysis of varicosities in the paraventricular nucleus.

scientific article published in January 1993

Noradrenergic innervation of vasopressin- and oxytocin-containing neurons in the hypothalamic paraventricular nucleus of the macaque monkey: quantitative analysis using double-label immunohistochemistry and confocal laser microscopy.

scientific article published on March 1994

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

scientific article published on 2 December 2015

Plasma BDNF levels vary in relation to body weight in females

scientific article (publication date: 2012)

Presence and phosphorylation of transcription factors in developing dendrites

scientific article published in March 1998

Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.

scientific article

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

scientific article published on 08 March 2016

RNA amplification in brain tissues.

scientific article published in October 2002

RNA sequestration to pathological lesions of neurodegenerative diseases.

scientific article published in November 1998

Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.

scientific article published on 3 December 2011

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

scientific article published on October 2004

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

scientific article

Regional deafferentation down-regulates subtypes of glutamate transporter proteins

scientific article published on 01 December 1995

Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease

scientific article

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

scientific article

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.

scientific article published in February 1997

Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

scientific article

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.

scientific article

Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders.

scientific article published on June 2004

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment.

scientific article published on 25 October 2013

Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease.

scientific article

Target identification for CNS diseases by transcriptional profiling.

scientific article published on 15 October 2008

Terminal continuation (TC) RNA amplification without second strand synthesis

scientific article

The AMPA glutamate receptor GluR3 is enriched in oxytocinergic magnocellular neurons and is localized at synapses

scientific article published on 01 March 1995

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

scientific article published on 16 January 2020

The noradrenergic innervation density of the monkey paraventricular nucleus is not altered by early social deprivation.

scientific article published on August 1993

The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain.

scientific article

The stress-induced transcription factor NR4A1 adjusts mitochondrial function and synapse number in prefrontal cortex.

scientific article published on 2 January 2018

Transcriptional profiling of small samples in the central nervous system

scientific article

Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

scientific article

Vacuolar pathology in the median eminence of the hypothalamus after hyponatremia.

scientific article

Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function

scientific article published on 25 August 2014

List of works by Stephen D Ginsberg

A genotype resource for postmortem brain samples from the Autism Tissue Program

Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains.

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

Amplification of RNA transcripts using terminal continuation.

An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain.

Apolipoprotein E4 genotype compromises brain exosome production

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.

Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology

CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation (MCS).

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

Characterization of the putative cholesterol transport protein metastatic lymph node 64 in the brain

Cholinotrophic molecular substrates of mild cognitive impairment in the elderly.

Circulating Aβ40 influences plasma BDNF levels and white matter integrity

Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampus.

Combining online and in-person methods to evaluate the content validity of PROMIS fatigue short forms in rheumatoid arthritis

Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.

Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy.

Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the rat.

Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression.

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.

Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome

Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression

Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation.

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice

Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).

Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice

Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons

Expression profiling and pharmacotherapeutic development in the central nervous system.

Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder

Expression profiling in the aging brain: a perspective.

Expression profiling suggests microglial impairment in HIV neuropathogenesis.

Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis.

Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.

Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus.

Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

Functional genomic methodologies.

Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease.

Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease.

Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease.

Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.

Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome.

Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology

Hippocampal plasticity during the progression of Alzheimer's disease

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

Identification of CSPα clients reveals a role in dynamin 1 regulation.

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients

Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.

Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.

Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice

Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice

Measurement of myelin basic protein and of anti-basic protein antibodies by ELISA utilizing biotinylated antibodies

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

Methods and compositions for amplification and detection of microRNAs (miRNAs) and noncoding RNAs (ncRNAs) using the signature sequence amplification method (SSAM).

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

Mild cognitive impairment: pathology and mechanisms.

Mitotic Figures in the Median Eminence of the Hypothalamus ⬇️

Molecular and cellular pathophysiology of preclinical Alzheimer's disease

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease

Neuron-specific age-related decreases in dopamine receptor subtype mRNAs

Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.

Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease.

Non-NMDA glutamate receptors are present throughout the primate hypothalamus

Noradrenergic innervation of the hypothalamus of rhesus monkeys: distribution of dopamine-beta-hydroxylase immunoreactive fibers and quantitative analysis of varicosities in the paraventricular nucleus.

Noradrenergic innervation of vasopressin- and oxytocin-containing neurons in the hypothalamic paraventricular nucleus of the macaque monkey: quantitative analysis using double-label immunohistochemistry and confocal laser microscopy.

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

Plasma BDNF levels vary in relation to body weight in females