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List of works by Elisabetta Ciani

APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome

article

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

scientific article published on 25 January 2011

Activation of the ornithine decarboxylase-polyamine system and induction of c-fos and p53 expression in relation to excitotoxic neuronal apoptosis in normal and microencephalic rats.

scientific article published in June 1998

Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome

scientific article

Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones

scientific article

Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches

scientific article

CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling

scientific article

CDKL5 deficiency entails sleep apneas in mice

scientific article

CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling

scientific article published on 22 March 2019

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.

scientific article published on 19 August 2012

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice

scientific article

Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome.

scientific article published on 14 May 2008

Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases

scientific article published on 15 March 2006

Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of ornithine decarboxylase.

scientific article

Chronic pre-explant blockade of the NMDA receptor affects survival of cerebellar granule cells explanted in vitro.

scientific article published in March 1997

Correction to: Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons

scientific article published on 17 February 2020

Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells

scientific article published in August 2005

Decreased excitotoxic sensitivity in the olfactory cortex of adult rats after neonatal NMDA blockade.

scientific article published in October 1994

Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells

scientific article

Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity

scientific article published in March 2004

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

scientific article published in June 2010

Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome

scientific article published on 3 September 2012

Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression

scientific article published on 13 August 2012

Effect of early isolation on signal transfer in the entorhinal cortex-dentate-hippocampal system.

scientific article

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

scientific article published on 27 July 2016

Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.

scientific article

Immunohistochemical localization of calbindin-D28K in telencephalic regions of microencephalic rats.

scientific article published on April 1994

Impact of environmental enrichment on neurogenesis in the dentate gyrus during the early postnatal period

scientific article published on 9 August 2011

Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons

scientific article published on 30 January 2020

Induction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac.

scientific article

Induction of type I PACAP receptor expression by the new zinc finger protein Zac1 and p53

scientific article published on 01 December 1998

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome

scientific article published on 5 August 2015

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

scientific article

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

scientific article published on January 2011

Lithium Restores Age-related Olfactory Impairment in the Ts65Dn Mouse Model of Down Syndrome

scientific article published in August 2016

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome

scientific article

Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.

scientific article published in May 1994

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

scientific article

Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice

scientific article published on 10 December 2014

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

scientific article

Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation

scientific article published on 3 April 2009

Mapping pathological phenotypes in a mouse model of CDKL5 disorder

scientific article

Neonatal isolation impairs neurogenesis in the dentate gyrus of the guinea pig.

scientific article published in January 2007

Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neurons

scientific article published in June 2005

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

scientific article published on 17 December 2007

Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.

scientific article published in November 1997

Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation

scientific article published on 25 August 2004

Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation

scientific article published on 3 October 2002

Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide

scientific article published in September 2002

Ornithine decarboxylase is differentially induced by kainic acid during brain development in the rat.

scientific article published in February 1993

Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome

scientific article

Postnatal neurogenesis in the dentate gyrus of the guinea pig.

scientific article published in January 2005

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.

scientific article

Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat.

scientific article published on 11 July 2006

Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation

scientific article published in November 2004

Sex differences in the hippocampal dentate gyrus of the guinea-pig before puberty ⬇️

scientific article published on January 1, 2003

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

scientific article published on 22 July 2016

Structural, neurochemical and behavioural consequences of neonatal blockade of NMDA receptor through chronic treatment with CGP 39551 or MK-801.

scientific article published in August 1993

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome

scientific article published on 05 June 2013

The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases

scientific article published on 17 October 2007

Timing of therapies for Down syndrome: the sooner, the better

scientific article

Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice.

scientific article published on 30 March 2018

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

scientific article published in April 2009

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

scientific article published on 6 December 2010

hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer

scientific article

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