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List of works by Dale W Laird

2005 International Gap Junction Conference Overview

A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction

scientific article published on 15 April 2016

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

scientific article

A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse

scientific article

A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells

scientific article published on August 2006

A mitosis-specific phosphorylation of the gap junction protein connexin43 in human vascular cells: biochemical characterization and localization.

scientific article published on April 1997

Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas

scientific article published on 9 April 2017

Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice

scientific article published on 27 February 2019

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

scientific article published on 13 March 2014

An update on minding the gap in cancer

scientific article published on 24 June 2017

Antibody perturbation analysis of gap-junction permeability in rat cardiac myocytes ⬇️

scientific article published on February 1, 1993

Aspects of gap junction structure and assembly

scientific article published on February 1, 1992

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms

scientific article published on 19 April 2013

Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells

scientific article

Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes

scientific journal article

Cellular Small Talk

Cellular immunolocalization of occludin during embryonic and postnatal development of the mouse testis and epididymis.

scientific article published in August 1999

Characterization and application of an in vitro detection system for studying the binding and phagocytosis of rod outer segments by retinal pigment epithelial cells

scientific article published on 01 May 1992

Characterization of gap junction proteins in the bladder of Cx43 mutant mouse models of oculodentodigital dysplasia.

scientific article published on June 2012

Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.

scientific article published on February 2011

Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism

scientific article

Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease

scientific article published on 18 December 2007

Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells

scholarly article

Comparative Analysis of Cx31 and Cx43 in Differentiation-Competent Rodent Keratinocytes

scientific article published on 14 October 2020

Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture

scientific article

Connexin Hemichannels: Methods for Dye Uptake and Leakage

scientific article published on September 2016

Connexin levels regulate keratinocyte differentiation in the epidermis

scientific article

Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation

scientific article

Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential

scientific article published on 8 February 2017

Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo

scientific article published on 02 December 2013

Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis

scientific article published on October 2006

Connexins and gap junctions in mammary gland development and breast cancer progression

scientific article published on 28 July 2007

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

scientific article

Connexins in skeletal muscle development and disease

scientific article published on 10 December 2015

Correction to: Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

scientific article

Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation

scientific article

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism

scientific article published on 15 June 2006

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer

scientific article published on 2 October 2015

Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions

scientific article published on 10 September 2015

Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques

scientific article published on 27 January 2009

Cx43 suppresses mammary tumor metastasis to the lung in a Cx43 mutant mouse model of human disease

scientific article published on 13 December 2010

Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia inGja1Jrt/+mice

scientific article published on 01 June 2010

Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia

scientific article published on 8 April 2008

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis

scientific article

Differential effects of pannexins on noise-induced hearing loss

scientific article

Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia

scientific article published on 9 April 2007

Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26.

scientific article

Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice

scientific article published on June 2017

Diverse post-translational modifications of the pannexin family of channel-forming proteins

scientific article

Diverse subcellular distribution profiles of pannexin 1 and pannexin 3.

scientific article

Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype

scientific article

Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation

scientific article published on 28 September 2014

Evaluation of mammary gland development and function in mouse models

scientific article

Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout

scientific article published in April 2013

Expression of pannexin isoforms in the systemic murine arterial network

scientific article

Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy

scientific journal article

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

scientific article

Functional Characterization of aGJA1Frameshift Mutation Causing Oculodentodigital Dysplasia and Palmoplantar Keratoderma

scientific article published in Journal of Biological Chemistry

Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants

scientific article published in July 2005

Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations

scientific article published on 19 February 2004

Functional role of a polymorphism in the Pannexin1 gene in collagen-induced platelet aggregation.

scientific article published on 7 May 2015

Gap junction remodeling in skin repair following wounding and disease

scientific article published on May 2013

Gap junctions and cancer: communicating for 50 years

scientific article published on 21 October 2016

Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules

scientific article published on April 2002

Gerald M. Kidder - bridging the gap in cell and developmental biology

scientific article published in February 2016

Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora.

scientific article published on 7 January 2016

Glycosylation regulates pannexin intermixing and cellular localization

scientific article published on 19 August 2009

Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects

scientific article

Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40.

scientific article published on 9 June 2010

Immunolocalization of serum amyloid A and AA amyloid in lysosomes in murine monocytoid cells: Confocal and immunogold electron microscopic studies

scientific article published on 01 August 1994

Implications and challenges of connexin connections to cancer.

scientific article

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation

scientific article published on 23 March 2010

Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss

scientific article published on 20 April 2017

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies ⬇️

scientific article published on October 1, 1992

Insights into the role of connexins in mammary gland morphogenesis and function

scientific article published on 19 March 2015

Introductory paper of the special issue on gap junctions in honor of Ross Johnson

scientific article published in June 2012

Life cycle of connexins in health and disease

scientific article

Loss of Gap Junction Plaques and Inhibition of Intercellular Communication in Ilimaquinone-treated BICR-M1R k and NRK Cells

scientific article published on 01 February 1997

Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis

scientific article

Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype

scientific article

Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells

scientific article published on 26 May 2003

Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function

scientific article

Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients.

scientific article

Mechanisms linking connexin mutations to human diseases

scientific article

Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration

scientific article

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.

scientific article

Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss

scientific article published on 04 May 2018

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged

scientific journal article

Molecular cloning, structure, and expression of a testicular follitropin receptor with selective alteration in the carboxy terminus that affects signaling function ⬇️

scientific article published on December 1, 1997

Multicolor and electron microscopic imaging of connexin trafficking

scientific article

Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies

scientific article published on 12 February 2014

Myogenic bladder defects in mouse models of human oculodentodigital dysplasia

scientific article published on February 2014

Neuronal differentiation and growth control of neuro-2a cells after retroviral gene delivery of connexin43.

scientific article published on November 2000

Next-Generation Connexin and Pannexin Cell Biology

scientific article published on 20 June 2016

ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation

scientific article published in June 2008

Ocular Pathology Relevant to Glaucoma in aGja1Jrt/+Mouse Model of Human Oculodentodigital Dysplasia

scholarly article by Edmund Tsui et al published 26 May 2011 in Investigative Ophthalmology Visual Science

Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43.

scientific article published on 10 January 2005

Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia

scientific article published on 23 February 2009

Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins

scientific article

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis

scientific article

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes

scientific article published on December 2011

Pannexin channels and their links to human disease

scientific article published on August 2014

Pannexin channels are not gap junction hemichannels

scientific article published on May 2011

Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis

scientific article

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions

scientific article

Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction

scientific article

Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing

scientific article

Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain

scientific article published on 9 June 2011

Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation

scientific article published on July 2005

Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.

scientific article

Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication

scientific article

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia

scientific article

Role of HSP90 in mediating cross-talk between the estrogen receptor and the Ah receptor signal transduction pathways.

scientific article published on November 1999

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone

scientific article

S-nitrosylation inhibits pannexin 1 channel function

scientific article

Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface

scientific article published on 11 May 2004

Selective localization of murine ApoSAA1/SAA2in endosomes-lysosomes in activated macrophages and their degradation products

SnapShot: Connexins and Disease

scientific article published in September 2017

Sodium Channel Distribution Within the Rabbit Atrioventricular Node as Analysed by Confocal Microscopy

scientific article published on 01 June 1997

Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia

scientific article

Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia

scientific article

Syndromic and non-syndromic disease-linked Cx43 mutations

scientific article

The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation

article

The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia

article

The biochemistry and function of pannexin channels

scientific article published on 28 January 2012

The cellular life of pannexins

The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells

scientific article

The gap junction proteome and its relationship to disease

scientific article

The life cycle of a connexin: gap junction formation, removal, and degradation.

scientific article published on August 1996

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants

scientific article

The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress

scientific article published on February 2008

The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice

scientific article

The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.

scientific article published on 20 April 2010

Trapping an intermediate form of connexin43 in the Golgi.

scientific article published in May 1993

Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes.

scientific article published on January 1991

Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression

scientific article

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