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List of works by Susan Wyllie

A comparative study of methylglyoxal metabolism in trypanosomatids

scientific article published on 3 December 2008

ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

scientific article published in November 2008

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

scientific article

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

scientific journal article

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 27 February 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 05 June 2017

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

scholarly article by Richard J Wall et al published August 2018 in Antimicrobial Agents and Chemotherapy

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions

scholarly article by Julien Pedron et al published 17 September 2018 in ChemMedChem

Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism

scientific article published on 6 January 2011

Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation

scientific article published on 3 December 2012

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 01 November 2018

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

scientific article published on April 2014

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

scientific article published on 2 October 2017

Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

scientific article published on July 2008

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

scientific article

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

scientific article

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

scientific article published on 28 October 2013

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

article published in the Proceedings of the National Academy of Sciences of the United States of America

Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

scientific article

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

scientific article published on 9 April 2013

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis

scientific article

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

scientific article published in Nature

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome

article

Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line

scientific article published on 28 November 2005

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

scientific article

Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major

scientific article published on 14 January 2011

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

scientific article

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

scientific article published on 27 May 2010

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

scholarly article published in Antimicrobial Agents and Chemotherapy

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

scientific article published on 25 November 2014

Identification and optimisation of a series of 8-hydroxy naphthyridines with potent in vitro antileishmanial activity: Initial SAR and assessment of in vivo activity

scientific article published on 14 July 2020

Identification of Chlamydia trachomatis genomic sequences recognized by chlamydial divalent cation-dependent regulator A (DcrA).

scientific article

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

scientific article published on 04 October 2021

Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony

scientific article

Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity

scientific article

Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

scientific article

Methylglyoxal metabolism in trypanosomes and leishmania

scientific article published on 15 February 2011

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

scientific article published on 09 March 2021

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

scientific article

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei

scientific article

Nongenotoxic 3-Nitroimidazo[1,2-]pyridines Are NTR1 Substrates That Display Potent Antileishmanial Activity

scientific article published on 19 December 2018

Norspermidine is not a self-produced trigger for biofilm disassembly

scientific article published on February 2014

Novel 8-nitroquinolin-2(1 H )-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study

scientific article published on 05 June 2018

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids

scientific article published in 2022

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

scientific article published on 18 December 2015

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

scholarly article by Victoriano Corpas-Lopez et al published 12 November 2018 in ACS Infectious Diseases

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

Quinol derivatives as potential trypanocidal agents

scientific article published on 27 December 2011

Refinement of techniques for the propagation of Leishmania donovani in hamsters

scientific article published on 7 February 2006

Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials

scientific article published on 4 February 2008

Setting Our Sights on Infectious Diseases

scientific article published on 06 December 2019

Snapshot Profiling of the Antileishmanial Potency of Lead Compounds and Drug Candidates against Intracellular Leishmania donovani Amastigotes, with a Focus on Human-Derived Host Cells

scientific article published on 9 January 2017

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

scientific article published on 30 January 2020

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis

scientific article

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

scientific article

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

scientific article published on 24 May 2016

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

scientific article published on 9 September 2013

Trypanothione-dependent glyoxalase I in Trypanosoma cruzi ⬇️

scientific article

Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

scientific article

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