List of works by Alain Couvineau

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

scientific article published on January 1995

Alanine scanning of VIP. Structure-function relationship for binding to human recombinant VPAC1 receptor

scientific article published on 01 January 2000

Antisecretory Effects of Chimeric Somatostatin/Dopamine Receptor Ligands on Gastroenteropancreatic Neuroendocrine Tumors.

scientific article published on 4 April 2017

Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production

scientific article published on 01 January 1997

Biological and structural analysis of truncated analogs of PACAP27.

scientific article

Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa

scientific article

Characterization of a common VIP-PACAP receptor in human small intestinal epithelium

scientific article published on 01 February 1993

Characterization of the new photoaffinity probe (Bz2-K24)-VIP.

scientific article published in July 2006

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.

scientific article published on 22 May 2015

Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

scientific article published on 22 May 2007

Class-B GPCR activation: is ligand helix-capping the key?

scientific article published on 12 June 2008

Cloning and functional characterization of the human VIP1/PACAP receptor promoter.

scientific article

Constitutive activation of the human VIP1 receptor

scientific article published on 01 December 1998

Constitutive activation of the human vasoactive intestinal peptide 1 receptor, a member of the new class II family of G protein-coupled receptors

scientific article published on 01 February 1998

Construction of chimeras between human VIP1 and secretin receptors: identification of receptor domains involved in selectivity towards VIP, secretin, and PACAP

scientific article published on 01 December 1998

Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP.

scientific article published on 6 July 2004

Dipeptidyl peptidase IV expression in rat jejunal crypt-villus axis is controlled at mRNA level ⬇️

scientific article published on November 1, 1991

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.

scientific article published on 6 August 2009

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

scientific article published on 18 August 2018

Establishment of a CHO cell clone stably expressing the recombinant human VIP-1 receptor

scientific article published on 01 December 1996

Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat.

scientific article published in July 2006

Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex

scientific article

Functional and immunological evidence for stable association of solubilized vasoactive-intestinal-peptide receptor and stimulatory guanine-nucleotide-binding protein from rat liver

scientific article published on 01 February 1990

G proteins in rat liver proliferation during cholestasis

scientific article published on 01 October 1994

Glycosylation of VIP receptors: a molecular basis for receptor heterogeneity.

scientific article published in May 1993

Gs and Gi protein subunits during cell differentiation in intestinal crypt-villus axis: regulation at the mRNA level.

scientific article

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP.

scientific article published on 23 December 2010

Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.

scientific article published on 10 April 2003

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide

scientific article (publication date: 4 August 2000)

Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice

scientific article

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

scientific article published on 9 January 2018

Interaction of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium: comparison with rat intestinal receptors.

scientific article published on March 1985

Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge

scientific article published on 28 June 2007

Localization and Processing of Glycosylphosphatidylinositol-Anchored Cathepsin D

scientific article published on 01 June 1995

Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP

scientific article (publication date: 15 October 2002)

Mutagenesis of N-glycosylation sites in the human VIP 1 receptor

scientific article published on 01 December 1996

Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

scientific article published on June 1995

Neurotensin Receptor and Its mRNA Are Expressed in Many Human Colon Cancer Cell Lines But Not in Normal Colonic Epithelium: Binding Studies and RT-PCR Experiments ⬇️

scientific article published on August 30, 1994

Novel receptor partners and function of receptor activity-modifying proteins

scientific article (publication date: 31 January 2003)

Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

scientific article published in Scientific Reports

PTHR1 mutations associated with Ollier disease result in receptor loss of function

scientific article published on 17 June 2008

Presence of a N-terminal signal peptide in class II G protein-coupled receptors: crucial role for expression of the human VPAC1 receptor.

scientific article published in December 2004

Purification of a galanin receptor from pig brain.

scientific article

Purification of vasoactive intestinal peptide receptor from porcine liver by a newly designed one-step affinity chromatography

scientific article published on 01 August 1990

Receptors for gut regulatory peptides.

scientific article published on January 1994

Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance

scientific article (publication date: 9 June 2011)

Regional expression of epithelial dipeptidyl peptidase IV in the human intestines

scientific article published on 01 September 1994

Role of cysteine residues in the N-terminal extracellular domain of the human VIP 1 receptor for ligand binding. A site-directed mutagenesis study

scientific article published on 01 December 1996

Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.

scientific article

Site-directed mutagenesis of human VIP1 versus VIP2 receptors

scientific article published on 01 December 1998

Solubilization and hydrodynamic characterization of guanine nucleotide sensitive vasoactive intestinal peptide-receptor complexes from rat intestine

scientific article published on 01 February 1989

Solubilization and hydrodynamic properties of active peptide YY receptor from rat jejunal crypts. Characterization as a Mr 44,000 glycoprotein

scientific article published on 01 June 1991

Solubilization of active and stable receptors for vasoactive intestinal peptide from rat liver

scientific article published on 01 April 1989

Solubilization of the liver vasoactive intestinal peptide receptor. Hydrodynamic characterization and evidence for an association with a functional GTP regulatory protein

scientific article published on 01 November 1986

Spatial approximation between the C-terminus of VIP and the N-terminal ectodomain of the VPAC1 receptor.

scientific article published in July 2006

Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.

scientific article published on April 1996

Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons.

scientific article published on 27 August 2015

Structural requirements for VIP interaction with specific receptors in human and rat intestinal membranes: effect of nine partial sequences

scientific article published on 01 June 1984

Study of species specificity in growth hormone-releasing factor (GRF) interaction with vasoactive intestinal peptide (VIP) receptors using GRF and intestinal VIP receptors from rat and human: evidence that Ac-Tyr1hGRF is a competitive VIP antagonist

scientific article published on 01 January 1986

Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays.

scientific article published on 28 July 2010

Synthesis of a hydrophilic affinity matrix for the purification of the vasoactive intestinal peptide receptor

scientific article published on 01 June 1993

The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role

scientific article published on 27 September 2018

The GIP receptor on pancreatic beta cell tumor: molecular identification by covalent cross-linking

scientific article published on 01 July 1984

The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.

scientific article published on 3 July 2008

The VPAC1 receptor: structure and function of a class B GPCR prototype.

scientific article

The human VPAC1 receptor: identification of the N-terminal ectodomain as a major VIP-binding site by photoaffinity labeling and 3D modeling

scientific article published on 01 July 2006

The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343

scientific article published on 01 January 1999

The human vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor 1 (VPAC1) promoter: characterization and role in receptor expression during enterocytic differentiation of the colon cancer cell line Caco-2Cl.20

scientific article

The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis

scientific article published on 5 June 2014

The rat liver vasoactive intestinal peptide binding site. Molecular characterization by covalent cross-linking and evidence for differences from the intestinal receptor.

scientific article published on January 1985

The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics

scientific article

Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

scientific article published on 28 December 2016

VIP receptors from porcine liver: High yield solubilization in a GTP-insensitive form ⬇️

scientific article published on January 1, 1991

VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins

scientific article

Vasoactive intestinal peptide (VIP)1 receptor. Three nonadjacent amino acids are responsible for species selectivity with respect to recognition of peptide histidine isoleucineamide.

scientific article published on May 1996

Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47phox phosphorylation pathway in monocytes.

scientific article

Vasoactive intestinal peptide receptors in rat liver after partial hepatectomy ⬇️

scientific article published on July 15, 1992

[Directed mutagenesis of human recombinant receptors of vasoactive intestinal peptide of VIP1 and VIP2 type. Difference in structure-activity relationship]

scientific article published on 01 January 1997

[Novel deglycosylation-independent roles for peptide N-glycanase]

scientific article published on 24 January 2014

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