List of works by Ferdinando Nicoletti

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

scientific article

(2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices.

scientific article published in May 1993

2008 Eruptions in metabotropic glutamate receptors.

scientific article published on 11 July 2008

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

scientific article published on 2 July 2015

A new 6-bp SOX-3 polyalanine tract deletion does not segregate with mental retardation.

scientific article

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

scientific article published on 11 January 2011

Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.

scientific article published in January 1986

Acetyl-L-carnitine in neuropathic pain: experimental data.

scientific article

Activation of Fas receptor is required for the increased formation of the disialoganglioside GD3 in cultured cerebellar granule cells committed to apoptotic death.

scientific article published in January 2004

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

scientific article

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

scientific article

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

scientific article

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

scientific article published on 12 August 2009

Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke.

scientific article

Agomelatine: protecting the CNS from the effects of stress

scientific article published on 01 October 2011

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

scientific article

Alzheimer's disease research enters a "new cycle": how significant?

scientific article

Amyloid beta protein does not interact with tachykinin receptors coupled to inositol phospholipid hydrolysis in human astrocytoma cells.

scientific article published in January 1993

An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats.

scientific article

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

scientific article

Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans.

scientific article published on June 2013

Antidepressant activity of fingolimod in mice.

scientific article published on 24 May 2015

Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus

scientific article published in November 2012

Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease

scientific article published on 12 August 2012

Beta-amyloid monomers are neuroprotective.

scientific article published in August 2009

Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats.

scientific article published in January 2013

CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations.

scientific article

Calcitonin and migraine

scientific article published on 01 April 1986

Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

scientific article published on 03 June 2008

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

scientific article

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

scientific article published on 5 March 2015

Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease

scientific article

Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices

scientific article published on 01 September 1993

Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats.

scientific article published on 19 April 2011

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats.

scientific article

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

scientific article published on 21 June 2016

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

scientific article published on 21 February 2014

Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.

scientific article

Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors.

scientific article published on 27 June 2006

Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice.

scientific article published in March 2002

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

scientific article published on 7 May 2010

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

scientific article published in October 2006

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

scientific article published on 14 March 2017

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

scientific article

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

scientific article published on 31 August 2011

Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

scientific article

Early defect of transforming growth factor β1 formation in Huntington's disease.

scientific article published on March 2011

Early life stress causes refractoriness to haloperidol-induced catalepsy.

scientific article published on 28 May 2013

Editorial

scientific article published in July 2006

Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data ⬇️

scientific article published on November 4, 1982

Effects of escitalopram on serum BDNF levels in elderly patients with depression: a preliminary report

scientific article published on 17 January 2014

Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat.

scientific article published in January 1983

Effects of parathyroid hormone or haloperidol-induced catalepsy and nigral GAD activity.

scientific article published on March 1983

Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats.

scientific article published on 08 September 2008

Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels

scientific article published on 13 April 2015

Electrophysiological and metabolic effects of CHF5074 in the hippocampus: Protection against in vitro ischemia

scientific article published on 12 March 2014

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

scientific article published in April 2003

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

scientific article published in January 2004

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.

scientific article published in January 2005

Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells.

scientific article published in October 2006

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

scientific article published on 12 April 2008

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

scientific article

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

scientific article

Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

scientific article

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

scientific article published on 18 October 2002

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

scientific article published on 7 October 2011

Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression

scientific article published on 02 October 2013

Exposure to predator odor and resulting anxiety enhances the expression of the α2 δ subunit of voltage-sensitive calcium channels in the amygdala.

scientific article

Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes

scientific article published on 01 June 2000

Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging.

scientific article published in May 2005

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

scientific article

Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat ⬇️

scientific article published on March 12, 1984

Fingolimod protects cultured cortical neurons against excitotoxic death

scientific article

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

scientific article

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

scientific article published on 24 October 2017

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

scientific article published on 14 March 2013

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

scientific article published on 01 November 1989

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

scientific article published on 18 August 2017

Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

scientific article

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.

scientific article published on January 2014

Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease.

scientific article

Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.

scientific article published on 7 July 2008

Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders?

scientific article published on June 2007

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

scientific article

Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?

scientific article

Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats

scientific article

Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner

scientific article

High number of striatal dopaminergic neurons during early postnatal development: correlation analysis with dopaminergic fibers

scientific article published on 29 August 2008

Hyperalgesic activity of kisspeptin in mice.

scientific article published on 23 November 2011

Hyperalgesic activity of parathyroid hormone and its fragments in male rats

scientific article published on 01 March 1984

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

scientific article

In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.

scientific article published on 17 February 2008

Increased serum Dickkopf-1 levels in drug-abusing psychotic patients

scientific article published on 21 November 2011

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

scientific article

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

scientific article published in March 2005

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

scientific article

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

scientific article published in October 2008

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

scientific article published in April 2007

Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.

scientific article

Influence of sex steroids and prolactin on haloperidol-induced catalepsy.

scientific article published on November 1983

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

scientific article

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

scientific journal article

Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors

scientific article published on 19 January 2006

Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

scientific article published in February 2010

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

scientific article published on July 2006

Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.

scientific article published in March 2005

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

scientific article published on 4 February 2013

L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies

scientific article published on July 2006

Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.

scientific article published on December 1987

Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740.

scientific article published on 22 July 2014

Low-dose acetazolamide in the treatment of premenstrual dysphoric disorder: a case series

scientific article published on 21 January 2014

MGluR5 mediates the interaction between late-LTP, network activity, and learning

scientific article

Maternal exposure to low levels of corticosterone during lactation protects the adult offspring against ischemic brain damage.

scientific article published in June 2007

Metabotropic glutamate 1 receptor: current concepts and perspectives.

scientific article published on December 2008

Metabotropic glutamate receptor expression in cultured rat astrocytes and human gliomas

scientific article published on September 1, 1997

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

scientific article published on 25 July 2010

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

scientific article

Metabotropic glutamate receptors and the control of chronic pain

scientific article published on 29 October 2011

Metabotropic glutamate receptors as drug targets: what's new?

scientific article published on 12 December 2014

Metabotropic glutamate receptors in glial cells.

scientific article published on 26 April 2008

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

scientific article published on 25 January 2012

Metabotropic glutamate receptors in the basal ganglia motor circuit

scientific article

Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.

scientific article

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

scientific article published on July 1996

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

scientific article published on 24 July 2007

Metabotropic glutamate receptors: from the workbench to the bedside ⬇️

scientific article published on October 29, 2010

Metabotropic glutamate receptors: new targets for the control of tumor growth?

scientific article published on 11 April 2007

Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

scientific article published in January 2004

Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility

scientific article

Molecular determinants of metabotropic glutamate receptor signaling.

scientific article

Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: an overview.

scientific article published on 29 May 2012

Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis

scientific article published on 19 May 2014

Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes

scientific journal article

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

scientific article published on 7 August 2015

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

scientific article

Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia.

scientific article published on 28 March 2007

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

scientific article published on 23 October 2012

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

scientific article published on 01 January 2020

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

scientific article

Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.

scientific article published on 10 July 2007

Neurodevelopment in schizophrenia: the role of the wnt pathways

scientific article

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

scientific article published in August 2001

Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture

scientific article published on 01 July 2000

Neuroprotective effect of prenyloxycoumarins from edible vegetables.

scientific article published on 26 July 2008

Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures

article

New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.

scientific article

Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.

scientific article published on June 2005

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

scientific article published on 06 April 2011

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells.

scientific article

Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain, and its expression is enhanced by the EphB1 ligand, ephrinB2.

scientific article published in January 2005

Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture

scientific article published on 01 December 1997

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article published on 11 April 2017

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

scientific article published in November 2004

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

scientific article

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

scientific article published on 13 September 2017

Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells

scientific article published on 01 June 1988

Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.

scientific article published on 16 November 2011

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

scientific article published on 29 December 2006

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

scientific article

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

scientific article published in July 2006

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

scientific article published on July 2005

Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.

scientific article

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

scientific article published on 19 November 2013

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

scientific article

Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity

scientific article published on 01 April 1981

Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

scientific article published on 15 June 2012

Predominant expression of group-II metabotropic glutamate receptors in the goldfish brain.

scientific article

Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats.

scientific article

Profile of gantenerumab and its potential in the treatment of Alzheimer's disease

scientific article

Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.

scientific article

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

scientific article

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

scientific article published on 26 January 2011

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

scientific article published on August 2003

Proteomic characterization in the hippocampus of prenatally stressed rats.

scientific article published on 30 December 2011

Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease.

scientific article published in November 2007

Relationship between learning, stress and hippocampal brain-derived neurotrophic factor.

scientific article published in January 2003

Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

scientific article published on 01 January 1989

Role of prolactin-opiate interactions in the central regulation of pain threshold ⬇️

scientific article published on August 1, 1983

Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer's Disease: Implications for the Treatment

scientific article published on April 2013

SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes

scientific article published in April 2009

Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.

scientific article published in September 1998

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice

scientific article

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

scientific article published on 01 September 2000

Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins.

scientific article published on 19 October 2013

Similarities between methamphetamine toxicity and proteasome inhibition.

scientific article published in October 2004

Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE.

scientific article published on 8 July 2009

Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II

scientific article published on 01 November 2000

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

scientific article published on 8 July 2008

Synaptic plasticity as a therapeutic target in the treatment of autism-related single-gene disorders.

scientific article published on January 2013

Synaptic plasticity in multiple sclerosis and in experimental autoimmune encephalomyelitis.

scientific article published on 02 December 2013

Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents

scientific article published on 01 March 2000

TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.

scientific article

TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.

scientific article

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

scientific article

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

scientific article published on 15 December 2010

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

scientific article published on 24 October 2015

Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.

scientific article published in March 2004

The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression

scientific article published on 15 September 2011

The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.

scientific article

The Val66Met polymorphism of the BDNF gene influences trigeminal pain-related evoked responses

scientific article published on 14 August 2012

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

scientific article published on 22 April 2008

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.

scientific article published on January 2011

The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes.

scientific article published on May 2004

The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development.

scientific article published on January 2008

The conditioned eyeblink reflex: a potential tool for the detection of cerebellar dysfunction in multiple sclerosis.

scientific article published on 25 May 2011

The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders.

scientific article published in February 2014

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

scientific article published on 29 April 2016

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.

scientific article published on November 2006

The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders.

scientific article

The origin recognition complex subunit, ORC3, is developmentally regulated and supports the expression of biochemical markers of neuronal maturation in cultured cerebellar granule cells.

scientific article published on 29 July 2010

The presence of depressive symptoms in comorbidity with Alzheimer's disease does not influence changes in serum brain-derived neurotrophic factor levels in older patients

scientific article published in April 2014

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

scientific article published on 01 August 2007

The wnt pathway in mood disorders

scientific article

The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?

scientific article published on 8 March 2017

Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro

scientific article published on October 23, 1992

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

scientific article

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

scientific article published on 11 January 2010

Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders.

scientific article

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

scientific article

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

scientific article published on 23 December 2015

Type-3 metabotropic glutamate receptors negatively modulate bone morphogenetic protein receptor signaling and support the tumourigenic potential of glioma-initiating cells.

scientific article

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

scientific article

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

scientific article

Vitamin D3: a helpful immuno-modulator

scientific article published on October 2011

WAG/Rij rats show a reduced expression of CB₁ receptors in thalamic nuclei and respond to the CB₁ receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges.

scientific article published on 3 February 2010

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

scientific article

[Evidence on the key role of the metabotrobic glutamatergic receptors in the pathogenesis of schizophrenia: a "breakthrough" in pharmacological treatment]

scientific article published on 01 March 2012

mGLU3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage.

scientific article published in May 2010

mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at Schaffer collateral-CA1 synapses mediates metaplasticity

scientific article published on September 2014

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

scientific article

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