List of works - John K McCormick

A Novel Loop Domain in Superantigens Extends their T Cell Receptor Recognition Site

scientific article

A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk

scientific article published on 09 August 2019

A robust scoring system to evaluate sepsis severity in an animal model.

scientific article

An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid

scientific article published on May 2004

Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides

article

Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.

scientific article

Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway

article

Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

scientific article

CD1d- and MR1-Restricted T Cells in Sepsis

scientific article

CD1d‐independent activation of mouse and human iNKT cells by bacterial superantigens ⬇️

scientific article published on November 1, 2011

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3. Implications for the evolution of staphylococcal pathogenicity islands

scientific article published on 30 January 2002

Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks

scientific article

Colicin V can be produced by lactic acid bacteria

scientific article published on 01 July 1999

Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen.

scientific article

Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II

scientific article

Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens

scientific article

Development of Streptococcal Pyrogenic Exotoxin C Vaccine Toxoids That Are Protective in the Rabbit Model of Toxic Shock Syndrome

article

Digoxigenin-labelled peptide nucleic acid to detect lactobacilli PCR amplicons immobilized on membranes from denaturing gradient gel electrophoresis.

scientific article

Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections

scientific article published on 20 May 2020

Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

scientific article published on 30 September 2003

Expression, purification, and detection of novel streptococcal superantigens

scientific article published on 01 January 2003

Formation of Vegetations during Infective Endocarditis Excludes Binding of Bacterial‐Specific Host Antibodies toEnterococcus faecalis

scientific article published on 11 March 2002

Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes

scientific article published on August 2003

Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen.

scientific article

Genetic characterization and heterologous expression of brochocin-C, an antibotulinal, two-peptide bacteriocin produced by Brochothrix campestris ATCC 43754

scientific article

Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence

scientific article

Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus.

scientific article

Identification of a two-component Class IIb bacteriocin in Streptococcus pyogenes by recombinase-based in vivo expression technology

scientific article

Influence of the vaginal microbiota on toxic shock syndrome toxin 1 production by Staphylococcus aureus.

scientific article published on 11 January 2013

Invariant Natural Killer T Cells Are Pathogenic in the HLA-DR4-Transgenic Humanized Mouse Model of Toxic Shock Syndrome and Can Be Targeted to Reduce Morbidity

scientific article

Long-range cooperative binding effects in a T cell receptor variable domain.

scholarly article

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

scientific article published on 26 November 2019

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immun

scientific article

Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.

scientific article published on December 2006

Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity.

scientific article published on January 2016

Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells

scientific article published on 9 August 2017

Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats

scientific article published on August 2008

Potential uses of probiotics in clinical practice

scientific article

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

scientific article published on 06 October 2020

Pyrogenic, lethal, and emetic properties of superantigens in rabbits and primates

scientific article published on 01 January 2003

Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.

scientific article published on 20 February 2017

Rapid detection of meticillin-resistant Staphylococcus aureus bacteraemia using combined three-hour short-incubation matrix-assisted laser desorption/ionization time-of-flight MS identification and Alere Culture Colony PBP2a detection test.

scientific article

Recalcitrant prosthetic valve endocarditis requiring repeated reconstruction: running out of options.

scientific article

Regulation of toxic shock syndrome toxin-1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins

scientific article published on 30 July 2019

Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo

scientific article published on February 2002

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

scientific article

Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.

scientific article published on 15 January 2018

Staphylococcal superantigens in colonization and disease

scientific article

Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1.

scientific article

Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes

scientific article

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization

scientific article published on 22 May 2015

Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo

scientific article

Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis.

scientific article published in January 2004

Survival and recovery of Aeromonas hydrophila in water: development of methodology for testing bottled water in Canada

article

Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome.

scientific article

T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis.

scientific article published in November 2014

The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus.

scientific article published on 25 July 2016

The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines

scientific article published on 30 April 2020

The T Cell Receptor β-Chain Second Complementarity Determining Region Loop (CDR2β) Governs T Cell Activation and Vβ Specificity by Bacterial Superantigens ⬇️

scientific article published on December 2, 2010

The zinc-dependent major histocompatibility complex class II binding site of streptococcal pyrogenic exotoxin C is critical for maximal superantigen function and toxic activity

scientific article

Time for probiotics

scientific article published on 01 August 2002

Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome.

scientific article published in June 2009

List of works by John K McCormick

A Novel Loop Domain in Superantigens Extends their T Cell Receptor Recognition Site

A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk

A robust scoring system to evaluate sepsis severity in an animal model.

An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid

Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides

Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.

Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway

Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

CD1d- and MR1-Restricted T Cells in Sepsis

CD1d‐independent activation of mouse and human iNKT cells by bacterial superantigens ⬇️

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3. Implications for the evolution of staphylococcal pathogenicity islands

Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks

Colicin V can be produced by lactic acid bacteria

Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen.

Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II

Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens

Development of Streptococcal Pyrogenic Exotoxin C Vaccine Toxoids That Are Protective in the Rabbit Model of Toxic Shock Syndrome

Digoxigenin-labelled peptide nucleic acid to detect lactobacilli PCR amplicons immobilized on membranes from denaturing gradient gel electrophoresis.

Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections

Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

Expression, purification, and detection of novel streptococcal superantigens

Formation of Vegetations during Infective Endocarditis Excludes Binding of Bacterial‐Specific Host Antibodies toEnterococcus faecalis

Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes

Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen.

Genetic characterization and heterologous expression of brochocin-C, an antibotulinal, two-peptide bacteriocin produced by Brochothrix campestris ATCC 43754

Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence

Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus.

Identification of a two-component Class IIb bacteriocin in Streptococcus pyogenes by recombinase-based in vivo expression technology

Influence of the vaginal microbiota on toxic shock syndrome toxin 1 production by Staphylococcus aureus.

Invariant Natural Killer T Cells Are Pathogenic in the HLA-DR4-Transgenic Humanized Mouse Model of Toxic Shock Syndrome and Can Be Targeted to Reduce Morbidity

Long-range cooperative binding effects in a T cell receptor variable domain.

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immun

Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.

Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity.

Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells

Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats

Potential uses of probiotics in clinical practice

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Pyrogenic, lethal, and emetic properties of superantigens in rabbits and primates

Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.

Rapid detection of meticillin-resistant Staphylococcus aureus bacteraemia using combined three-hour short-incubation matrix-assisted laser desorption/ionization time-of-flight MS identification and Alere Culture Colony PBP2a detection test.

Recalcitrant prosthetic valve endocarditis requiring repeated reconstruction: running out of options.

Regulation of toxic shock syndrome toxin-1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins

Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.

Staphylococcal superantigens in colonization and disease

Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1.

Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization

Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo

Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis.

Survival and recovery of Aeromonas hydrophila in water: development of methodology for testing bottled water in Canada

Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome.

T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis.

The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus.

The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines

The T Cell Receptor β-Chain Second Complementarity Determining Region Loop (CDR2β) Governs T Cell Activation and Vβ Specificity by Bacterial Superantigens ⬇️

The zinc-dependent major histocompatibility complex class II binding site of streptococcal pyrogenic exotoxin C is critical for maximal superantigen function and toxic activity

Time for probiotics

Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome.