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List of works by Paolo Sportoletti

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells

scientific article

A novel NOTCH1 PEST domain mutation in a case of chronic lymphocytic leukemia

scientific article published on 10 December 2012

A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia.

scientific article published on 9 October 2013

A scale of "bad" co-mutations in NPM1-driven AML.

scientific article published in October 2017

Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?

scientific article published on 28 October 2010

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.

scientific article published on 20 March 2015

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

scientific article published on 5 December 2014

BRAF mutations in hairy-cell leukemia

scientific article

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice

scientific article published on 06 November 2020

CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity.

scientific article published on 4 July 2011

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus

scientific article published on 09 July 2020

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation.

scientific article published on 26 November 2014

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

scientific article published on 12 February 2019

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita

scientific article published on 30 September 2019

Glucocorticoid-Induced TNFR family Related gene (GITR) enhances dendritic cell activity

scientific article published on 29 September 2010

How Does the NPM1 Mutant Induce Leukemia? ⬇️

scientific article published on June 22, 2011

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

scientific article

Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation

scientific article published on 29 June 2011

Interleukin-7-engineered mesenchymal cells: in vitro effects on naive T-cell population.

scientific article published in December 2006

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice.

scientific article published on 14 August 2015

Loss of bone mineral density and secondary hyperparathyroidism are complications of autologous stem cell transplantation

scientific article published on 01 May 2007

Mesenchymal cells recruit and regulate T regulatory cells

scientific article published on 01 March 2008

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis

scientific article

Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.

scientific article published on 02 September 2014

Mutational landscape of AML with normal cytogenetics: biological and clinical implications.

scientific article published on 20 December 2012

NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion.

scientific article

NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

scientific article published on 31 August 2010

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.

scientific article

Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction

scientific article published on 05 December 2012

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

scientific article published on 22 January 2008

Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.

scientific article published on 19 April 2015

Recurrent primary plasmacytoma of the eyelid with rapid regional metastasis

scientific article published on 01 March 2006

Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study

scientific article published on 14 April 2020

T regulatory cell separation for clinical application.

scientific article published on 12 July 2012

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

scientific article

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.

scientific article published on 22 February 2013

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.

scientific article published on 4 June 2007

Uncommon lymphoplasmacytic lymphoma with IgA paraproteinemia: a challenging clinical diagnosis solved by MYD88 mutation analysis

scientific article published on 13 November 2018

Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

scientific article

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.

scientific article

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