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List of works by Ian Stratford

17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response.

scientific article published on January 2002

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

scientific article published on July 1997

2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives

scientific article published on September 18, 1992

3-Nitro-1,2,4-triazoles as hypoxia-selective agents.

scientific article published on August 1989

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

scientific article published on October 2003

31P MRS to monitor the induction of tumor hypoxia by the modification of the oxygen affinity of hemoglobin using BW 589C

scientific article published on 01 May 1994

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro

scientific article published on March 1, 1998

A biochemical assessment of the neurotoxicity of the radiosensitizing drug misonidazole in the rat.

scientific article published on December 1981

A biochemical method for assessing the neurotoxic effects of misonidazole in the rat

scientific article

A biochemical neurotoxicity study relating the neurotoxic potential of metronidazole and nitrofurantoin with misonidazole

scientific article published on 01 March 1982

A comparison of adriamycin and mAMSA in vitro: cell lethality and SCE studies

scientific article published on December 1981

A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids.

scientific article

A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour

scientific article published on January 1996

A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties

scientific article published on July 1978

A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs

scientific article

A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

scientific article

A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis

scientific article published on January 2002

A similarity model for the human angiogenic factor, thymidine phosphorylase/platelet derived-endothelial cell growth factor

scientific article

A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions

scientific article

A synthetic approach to novel carvotacetone and antheminone analogues with anti-tumour activity.

scientific article published on 26 July 2013

Abnormal radiosensitizing and cytotoxic properties of ortho-substituted nitroimidazoles

scientific article published on 01 January 1983

Abstract 3042: The novel Akt inhibitor AZD5363 following radiotherapy improves tumor control in mouse models of head and neck cancer

Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer

scientific article published on 17 April 2013

Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade

scientific article published in October 2014

Akt inhibition improves long-term tumour control following radiotherapy by altering the microenvironment

scientific article published on 30 October 2017

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

scientific article published in January 2005

Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

scientific article published on 15 December 2006

Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo

scientific article published on 01 July 1986

Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.

scientific article

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

scientific article published on January 2004

Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

scientific article published on 21 August 2007

Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs

scientific article published on 01 January 1992

Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers.

scientific article published on July 1991

Binding and Internalization in Receptor-Targeted Carriers: The Complex Role of CD44 in the Uptake of Hyaluronic Acid-Based Nanoparticles (siRNA Delivery)

scientific article published on 18 November 2019

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships

scientific article published in October 1999

Bioreductive and gene therapy approaches to hypoxic diseases

scientific article

Bioreductive drugs and the selective induction of tumour hypoxia

scientific article

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

scientific article published on 01 January 1992

Bioreductive drugs for cancer therapy: the search for tumor specificity

scientific article published on May 1994

Bioreductive drugs into the next millennium

scientific article published on 01 September 1998

Can 31P magnetic resonance spectroscopy measurements of changes in experimental tumour metabolism be related to modification of oxygenation status?

scientific article published on 01 January 1992

Cancer chemotherapy and drug metabolism.

scientific article published in August 2005

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1.

scientific article

Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs

scientific article published on July 1996

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

scientific article published on December 2007

Chemopotentiation by CB 1954: the importance of postincubations and the possible involvement of poly(ADP-ribosylation)

scientific article published on 01 September 1984

Chemosensitization by monofunctional alkylating agents

scientific article published on 01 August 1986

Chemosensitization in vitro: potentiation of melphalan toxicity by misonidazole, metronidazole and nitrofurazone

scientific article published on 01 March 1982

Chirality of a 1,10-bisacetoxymitosene compound. Impact on reductive activation, DNA interstrand cross-linking and antitumour activity.

scientific article published on July 1996

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery

scientific article

Clinical development of new drug-radiotherapy combinations ⬇️

scientific article published on June 2016

Combination of photodynamic therapy (PDT) and melphalan in experimental tumors.

scientific article published on June 1994

Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro

scientific article published on April 1980

Combining bioreductive drugs and radiation for the treatment of solid tumors.

scientific article

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

scientific article published on 01 February 2007

Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT)

scientific article published on 01 May 1994

Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model

scientific article

Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression.

scientific article published on April 2005

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.

scientific article

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107] ⬇️

scientific article published on 19 June 2018

Corrigendum: Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

scientific article published on 01 December 2017

Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

scientific article published on 14 November 2007

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

scientific article published on 01 October 1994

Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction

scientific article published on 01 June 1994

Cytotoxic properties of a 4-nitroimidazole (NSC 38087): a radiosensitizer of hypoxic cells in vitro

scientific article published on July 1981

Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro

scientific article published on October 1980

Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation.

scientific article published on March 2004

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions

scientific article published on August 1990

Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.

scientific article

Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells

scientific article

Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites ⬇️

scientific article published on June 1, 1993

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

scientific article published in January 2004

Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)

scientific article published on 27 August 2019

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1)

scientific article published on 15 September 2008

Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?

scientific article published on December 1999

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908) ⬇️

scientific article published on 01 January 1992

Dual induction of the Epo-Egr-TNF-alpha- plasmid in hypoxic human colon adenocarcinoma produces tumor growth delay.

scientific article published in January 2003

Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.

scientific article published in May 2005

Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas

scientific article published on 01 October 1990

Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069

scientific article published on 01 April 1988

Effect of hydralazine in spontaneous tumours assessed by oxygen electrodes and 31P-magnetic resonance spectroscopy

scientific article

Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro ⬇️

scientific article published on March 1, 1977

Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N).

scientific article

Effects of some hypoxic cell radiosensitizers on the decay of potentially lethal oxygen-dependent damage in fully hydrated spores ⬇️

scientific article published on June 1, 1978

Electron-affinic sensitization VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. 1976.

scientific article published in August 2012

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers

scientific article published on 01 July 1976

Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

scientific article published on 04 March 2014

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

scientific article

Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase ⬇️

scientific article published on January 1, 1997

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

scientific article published on June 2000

Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents

scientific article published on 01 May 1989

Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship

scientific article published on December 1982

Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air

scientific article published on July 1982

Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase

scientific article published on 01 March 1996

Enzymology of tirapazamine metabolism: a review

scientific article published on 01 September 1998

Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44

scientific article published on 01 May 2019

Evaluation of analogues of furan-amidines as inhibitors of NQO2.

scientific article published on 12 March 2018

Evaluation of novel radiation sensitizers in vitro and in vivo.

scientific article published on March 1982

Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen

scientific article published on 01 January 2000

Evidence for a non-thermal effect of ultrasound.

scientific article

Exogenous and endogenous markers of tumour oxygenation status: definitive markers of tumour hypoxia?

scientific article

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

scientific article

Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix.

scientific article published on February 2005

Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome

scientific article published in January 2007

Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man

scientific article published on 01 May 1994

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

scientific article published on 01 January 1994

Fused pyrazine mono-N-oxides as bioreductive drugs. III. Characterization of RB 90740 in vitro and in vivo.

scientific article published on April 1995

GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding.

scientific article published on March 2003

Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

scientific article

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix

scientific article published in April 2001

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

scientific article published on 19 July 2011

Guidelines for the welfare and use of animals in cancer research

scientific article

HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells

scientific article published on 28 May 2007

Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor

scientific article published on 01 September 1999

Heterocyclic mono-N-oxides with potential applications as bioreductive anti-tumour drugs: Part 1. 8-Alkylamino-substituted phenylimidazo [1,2-a] quinoxalines

scientific article published on 01 December 1993

High efficiency of ferricenium salts as radiosensitizers of V79 cells in vitro and the KHT tumor in vivo

scientific article published on 01 April 1989

High uptake of RSU 1069 and its analogues melanotic melanomas

scientific article published on 01 January 1989

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

scientific article published on 10 December 2019

Hypoxia and oxidative stress. Tumour hypoxia--therapeutic considerations

scientific article

Hypoxia in tumors: molecular targets for anti-cancer therapeutics.

scientific article

Hypoxia response elements

article

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure

scientific article published in February 2004

Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.

scientific article published on December 2004

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

scientific article

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

scientific article published on April 2004

Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview

scientific article

Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenog

scientific article published on June 2005

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

scientific article

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

scientific article published in November 2003

Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.

scientific article published on 15 March 2010

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

scientific article published on November 1995

In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B Signaling

scientific article

In silico identification and biochemical characterization of novel inhibitors of NQO1

scientific article published on 29 September 2006

In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

scientific article published on 21 October 2010

In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts: effects of blood flow modification

scientific article published on November 1991

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

scientific article

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

scientific article

Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145 ⬇️

scientific article published on December 1, 1992

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

scientific article published on 01 July 1998

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine

scientific article published on 01 December 1994

Induction of hypoxia in normal and malignant tissues by changing the oxygen affinity of hemoglobin--implications for therapy

scientific article published on 01 August 1986

Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid

scientific article published on 01 February 1991

Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin

scientific article published on 01 May 1989

Induction of tumour hypoxia by FAA and TNF: interaction with bioreductive drugs

scientific article published on 01 July 1991

Induction of tumour hypoxia by a vasoactive agent. A combined NMR and radiobiological study

scientific article published on June 1989

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo

scientific article published on 01 March 1989

Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

scientific article

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cellsin vitro

article

Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

scientific article

Inhibition of vascular endothelial growth factor signalling using cediranib (RECENTIN; AZD2171) enhances radiation response and causes substantial physiological changes in lung tumour xenografts

scientific article published in October 2008

Inhibitors of NQO1: identification of compounds more potent than dicoumarol without associated off-target effects.

scientific article published on 21 October 2010

Insoluble derivatives of polynucleotide-phosphorylase

scientific article published on 01 March 1973

Interaction of the cytotoxic and sensitizing effects of electron-affinic drugs and hyperthermia

scientific article published on 01 June 1982

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy

scientific article published on 5 March 2016

Investigation of radiosensitivity gene signatures in cancer cell lines.

scientific article published on 22 January 2014

Keynote address: Concepts and developments in radiosensitization of mammalian cells ⬇️

scientific article published on January 1, 1992

Magnetic resonance spectroscopic studies on 'real-time' changes in RIF-1 tumour metabolism and blood flow during and after photodynamic therapy

scientific article published on June 1994

Magnetic resonance spectroscopy studies on experimental murine and human tumors: Comparison of changes in phosphorus metabolism with induced changes in vascular volume ⬇️

scientific article published on 01 January 1992

Mammalian cell toxicity of nitro compounds : dependence upon reduction potential

scientific article published on 01 October 1976

Manipulation and exploitation of the tumour environment for therapeutic benefit.

scientific article published on January 1994

Manipulation of radiobiological hypoxia in a human melanoma xenograft to exploit the bioreductive cytotoxicity of RSU-1069

scientific article published on 01 November 1989

Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage

scientific article published in April 1987

Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway

scientific article published in February 2002

Metabolic profiling of hypoxia-inducible factor-1β-deficient and wild type Hepa-1 cells: effects of hypoxia measured by 1H magnetic resonance spectroscopy

Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.

scientific article

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine.

scientific article published in June 1994

Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting

scientific article published in August 2005

Monitoring metabolic responses after induction of hypoxia in the KHT tumour using 31P NMR spectroscopy

scientific article published on 01 July 1991

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

scientific article published on 28 December 2017

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

scientific article

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)

scientific article published on 20 September 2019

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents

scientific article published in April 1999

Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs

scientific article published on 01 January 1991

No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix

scientific article published on January 2006

Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro

scientific article published in June 2003

Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria

scientific article

Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones

scientific article

Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice

scientific article published on July 1991

Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.

scientific article published on 7 December 2007

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

scientific article published on July 2002

PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

scientific article

Pharmacokinetics, metabolism and distribution of 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-A] pyrido [3,2-E] pyrazine-5-oxide in C3H mice.

scientific article published in May 1994

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

scientific article published in December 2004

Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy ⬇️

scientific article published on January 1, 1997

Potential antitumour mitosenes: relationship between in vitro DNA interstrand cross-link formation and DNA damage in Escherichia coli K-12 strains

scientific article published on October 1994

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

scientific article

Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine

scientific article

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

scientific article published on 14 June 2017

Preincubation with electron affinic radiosensitizers followed by hyperthermia or X rays

scientific article published on 01 March 1982

Pretreatment apoptosis in carcinoma of the cervix correlates with changes in tumour oxygenation during radiotherapy

scientific article published on March 2000

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones

scientific article published on 01 January 1999

Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection; results of EORTC Translational Research Fund studies

scientific article published in March 2004

Protection against misonidazole-induced neuropathy in rats: a biochemical assessment.

scientific article published on June 1983

Protection of pig epidermis against radiation-induced damage by the infusion of BW12C.

scientific article

Quinone bioreductive prodrugs as delivery agents

scientific article

RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo

scientific article published on 01 September 1984

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions

scientific article published on 01 January 1986

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

scientific article published on 13 January 2016

Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo

scientific article

Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity

scientific article published on 01 May 1994

Radiosensitization by the 2,4-dinitro-5-aziridinyl benzamide CB 1954: a structure/activity study

scientific article published in July 1987

Radiosensitization in vivo: a study with an homologous series of 2-nitroimidazoles

scientific article published on 01 October 1983

Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles

scientific article published on 01 August 1981

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands

scientific article published in August 1984

Radiosensitizers of hypoxic mammalian cells. 1-(Hydroxyaminoalkyl)-substituted nitroimidazoles

Radiosensitizing and Cytotoxicity Studies with CB 1954 (2,4-Dinitro-5-Aziridinylbenzamide)

scientific article published on 01 December 1981

Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase

scientific article

Radiotherapy Research Priorities for the UK

scientific article published on 02 April 2010

Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer

scientific article published on 22 July 2008

Reduction of tumour intracellular pH and enhancement of melphalan cytotoxicity by the ionophore Nigericin

scientific article published on 01 January 1995

Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

scientific article published on December 1995

Relationship between intracellular concentration and radiosensitizing effect of pimonidazole and etanidazole on two human melanoma cell lines

scientific article published on January 1993

Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole

scientific article published on January 1993

Relationship between topoisomerase II levels and resistance to topoisomerase II inhibitors in lung cancer cell lines.

scientific article published on July 1996

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

scientific article published in May 2002

Reversal of P-glycoprotein-mediated multidrug resistance by pure anti-oestrogens and novel tamoxifen derivatives

scientific article published on July 1994

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

scientific article published on 27 October 2005

Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion

scientific article published on March 2002

S-2-amino-5-(2-nitroimidazol-1-yl)pentanoic acid: a model for potential bioreductively activated prodrugs for inhibitors of nitric oxide synthase (NOS) activity

scientific article published on 01 January 1997

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

scientific article

Selective reversal of vinblastine resistance in multidrug-resistant cell lines by tamoxifen, toremifene and their metabolites.

scientific article published on January 1993

Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.

scientific article

Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice

scientific article

Spectrophotometric analysis of nucleic acids: oxygenation-dependent hyperchromism of DNA.

scientific article

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

scientific article published in Scientific Reports

Structure-activity relationships in the development of hypoxic cell radiosensitizers. I. Sensitization efficiency

scientific article published on February 1979

Structure-activity relationships in the development of hypoxic cell radiosensitizers. II. Cytotoxicity and therapeutic ratio

scientific article published on February 1979

Structure-activity relationships in the development of hypoxic cell radiosensitizers. III. Effects of basic substituents in nitroimidazole sidechains

scientific article published on 01 December 1980

Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues

scientific article published on 01 July 1986

Subharmonic emission as an indicator of ultrasonically-induced biological damage

scientific article published on 01 November 1983

Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988.

scientific article published on March 1995

Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1)

scientific article

Synthesis and cytotoxic activity of indolyl thiazoles ⬇️

scientific article published on June 1, 1997

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

scientific article published in March 2002

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase

scientific article published in November 2004

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively ac

scientific article published on 01 September 1990

Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins

scientific article published on September 1990

Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase.

scientific article published in September 2003

Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins

scientific article published on 01 July 1991

Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro

scientific article published on 01 January 1993

Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma

scientific article published on 18 October 2012

Targeting gene expression to hypoxic tumor cells

article

Targeting gene therapy to cancer: a review

scientific article published on January 1, 1997

Targeting hypoxia with a new generation of indolequinones

scientific article published on 01 September 1998

Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.

scientific article published on September 2010

The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages.

scientific article published on 19 December 2016

The anti-tumor immune response generated by radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade

The bioreductive agent RH1 and gamma-irradiation both cause G2/M cell cycle phase arrest and polyploidy in a p53-mutated human breast cancer cell line

scientific article published on February 2004

The decay of potentially lethal oxygen-dependent damage in fully hydrated Bacillus megaterium spores exposed to pulsed electron irradiation

scientific article published on November 1, 1977

The development of some nitroimidazoles as hypoxic cell sensitizers

scientific article published on 01 January 1980

The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action

scientific article published on March 1986

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

scientific article

The effect of caffeine on the cytotoxicity of misonidazole and some other nitroheterocyclic compounds

scientific article published on 01 August 1982

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in Chinese hamster lung fibroblasts and human breast-cancer cells in vitro

scientific article

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

scientific article

The experimental development of bioreductive drugs and their role in cancer therapy.

scientific article

The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy

scientific article

The impact of intracellular generation of nitric oxide on the radiation response of human tumor cells.

scientific article

The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.

scientific article published on January 2004

The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation

scientific article published on 01 November 1998

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

scientific article published on February 1997

The interaction between radiation and complexes of cis-Pt(II) and Rh(II): studies at the molecular and cellular level

scientific article published on 01 October 1985

The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report

scientific article published on 01 January 1980

The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts

scientific article published on 20 October 2009

The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy

scientific article

The radiation response of V79 and human tumour multicellular spheroids – cell survival and growth delay studies ⬇️

scientific article published on August 1, 1984

The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor

scientific article published in July 1986

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

scientific article published on 01 April 2000

The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31p magnetic resonance spectroscopy ⬇️

scientific article published on January 1, 1992

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

scientific article published in May 1994

The role of cavitation in the interaction of ultrasound with V79 Chinese hamster cells in vitro

scientific article

The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

scientific article

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

scientific article published on 01 August 1992

The toxicity of the radiosensitizer misonidazole towards hypoxic cells in vitro: a model for mouse and man

scientific article published on 01 September 1978

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

scientific article published on 12 March 2014

Thermotolerance in chinese hamster cells under oxic conditions after chronic culture under hypoxia ⬇️

scientific article published on April 1, 1981

Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo

scientific article published on 01 December 1984

Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro ⬇️

scientific article published on 01 July 1998

Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline.

scientific article published in November 2003

Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination

scientific article published on June 2005

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential

scientific article published on 01 March 1980

Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2.

scientific article

Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

article

Ultrasonic irradiation of mammalian cells in vitro at hyperthermic temperatures

scientific article published on 01 August 1980

Use of metronidazole and other nitroimidazole drugs in cancer therapy

scientific article published on September 1, 1978

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

scientific article published on December 2004

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts

scientific article published on September 2003

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

scientific article published in June 2008

ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model.

scientific article published on April 2002

ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

scientific article published in December 2004

iNOS as a therapeutic target for treatment of human tumors

scientific article published on 13 May 2008

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