List of works - Mauro Freccero

A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids

scientific article published on 29 October 2018

A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety

article

A Kinetic Evaluation of Carbon−Hydrogen, Carbon−Carbon, and Carbon−Silicon Bond Activation in Benzylic Radical Cations

scientific article published in 1998

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications

scientific article published on 7 July 2016

A computational workflow for the design of irreversible inhibitors of protein kinases.

scientific article published on 21 March 2010

A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes.

scientific article published in June 2015

A new method in radical chemistry: Generation of radicals by photo-induced electron transfer and fragmentation of the radical cation

A photoreactive G-quadruplex ligand triggered by green light.

scientific article published on 15 December 2014

A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging.

scientific article published on 2 February 2017

An Aggregating Amphiphilic Squaraine: A Light-up Probe That Discriminates Parallel G-Quadruplexes

scientific article published on 19 May 2017

An experimental and theoretical investigation of loperamide hydrochloride-glutaric acid cocrystals

scientific article

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.

scientific article

Assessment of gene promoter G‑quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells

scientific article

Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking

scientific article published on 16 November 2006

Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies

scientific article published on 19 November 2018

Cationic Pentaheteroaryls as Selective G-Quadruplex Ligands by Solvent-Free Microwave-Assisted Synthesis

scientific article published on 20 September 2012

Characterization of Methylenepropenylidenecyclohexadiene Derivatives and Their Competing 1,6-Electrocyclic Reaction and 1,7-Hydrogen Shift at Room Temperature

scientific article published in 1996

Concerted vs stepwise mechanism in 1,3-dipolar cycloaddition of nitrone to ethene, cyclobutadiene, and benzocyclobutadiene. A computational study

scientific article published on 01 September 2000

Conjugation, Substituent, and Solvent Effects on the Photogeneration of Quinone Methides.

scientific article

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

scientific article published on 03 May 2018

Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide

scientific article published on 20 September 2018

Dyads of G-Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration

scientific article published on 01 August 2019

Epoxidation of acyclic chiral allylic alcohols with peroxy acids: spiro or planar butterfly transition structures? A computational DFT answer

scientific article published on 01 April 2000

Facial selectivity in epoxidation of 2-cyclohexen-1-ol with peroxy acids. A computational DFT study

scientific article published on 01 December 2000

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

scientific article published on 20 December 2021

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

scientific article published on 11 January 2018

G-quadruplex fluorescence sensing by core-extended naphthalene diimides

scientific article

Homolytic vs heterolytic paths in the photochemistry of haloanilines

scientific article published in October 2003

Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.

scientific article

Hydrosoluble and solvatochromic naphthalene diimides with NIR absorption

scientific article published on 22 October 2013

Mechanochemical synthesis of bumetanide-4-aminobenzoic acid molecular cocrystals: a facile and green approach to drug optimization

scientific article

Modeling H-bonding and solvent effects in the alkylation of pyrimidine bases by a prototype quinone methide: a DFT study.

scientific article published in March 2003

Modeling substituent and conformational effects on the reactivity of antitumor agents containing a cyclopropylcyclohexadienone subunit

scientific article published in September 2004

Modeling the photochemistry of the reference phototoxic drug lomefloxacin by steady-state and time-resolved experiments, and DFT and post-HF calculations

scientific article published in January 2008

More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand

scientific article published on 01 November 2018

Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

scientific article published on 16 June 2011

Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells

scientific article published on 24 September 2018

Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

scientific article

Novel naphthalene diimides as activatable precursors of bisalkylating agents, by reduction and base catalysis.

scientific article published on 25 September 2007

Novel pathways for oxygen insertion into unactivated C-H bonds by dioxiranes. Transition structures for stepwise routes via radical pairs and comparison with the concerted pathway.

scientific article

Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding

Photoarylation of alkenes and heteroaromatics by dibromo-BINOLs in aqueous solution.

scientific article

Photoarylation/alkylation of bromonaphthols

scientific article

Photochemical Synthesis of 4-Oxobutanal Acetals and of 2-Hydroxycyclobutanone Ketals

Photogenerated quinone methides as useful intermediates in the synthesis of chiral BINOL ligands.

scientific article

Photoinduced SET for the functionalization of alkanes

Photoinduced, ionic Meerwein arylation of olefins.

scientific article

Photosensitized oxidation of sulfides: discriminating between the singlet-oxygen mechanism and electron transfer involving superoxide anion or molecular oxygen

scientific article

Planar transition structures in the epoxidation of alkenes. A DFT study on the reaction of peroxyformic acid with norbornene derivatives.

scientific article

Protecting Group Free Synthesis of 6-Substituted Naphthols and Binols

scientific article published on 08 March 2011

Pyrrolo[3',2':6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity

scientific article

Quinone methide generation via photoinduced electron transfer.

scientific article

Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.

scientific article

Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad.

scientific article published on 14 October 2015

Selective arylation, alkenylation, and cyclization of dibromonaphthols, using visible light, via carbene intermediates

scientific article published in August 2009

Selectivity of purine alkylation by a quinone methide. Kinetic or thermodynamic control?

scientific article published in August 2003

Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data

scientific article published on 06 June 2022

Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.

scientific article

Substituted heterocyclic naphthalene diimides with unexpected acidity. Synthesis, properties, and reactivity.

scientific article published in November 2009

Synthesis and antiproliferative mechanism of action of pyrrolo[3',2':6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers.

scientific article

Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines

scientific article published on 03 November 2018

Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.

scientific article

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

scientific article

Synthesis, spectroscopic characterization and chemical reactions of stable o-QM on solid phase

scientific article published on 01 September 2002

Targeting loop adenines in G-quadruplex by a selective oxirane.

scientific article published on 04 December 2012

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

scientific article published on 16 June 2016

The photochemical approach to the functionalization of open-chain and cyclic alkanes: 1. Single electron transfer oxidation

The photochemical approach to the functionalization of open-chain and cyclic alkanes: 2. Hydrogen abstraction

The photochemical reactions of 9,10-anthracenedicarbonitrile and 1,4-naphthalenedicarbonitrile in acetonitrile in the presence of bases

The role of SET in the deprotection of (thio)ketals under photosensitization by π-acceptors

Towards Building Blocks for Supramolecular Architectures Based on Azacryptates

scientific article published on 09 April 2020

Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands.

scientific article

Water-soluble naphthalene diimides as singlet oxygen sensitizers.

scientific article published on 5 August 2013

List of works by Mauro Freccero

A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids

A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety

A Kinetic Evaluation of Carbon−Hydrogen, Carbon−Carbon, and Carbon−Silicon Bond Activation in Benzylic Radical Cations

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications

A computational workflow for the design of irreversible inhibitors of protein kinases.

A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes.

A new method in radical chemistry: Generation of radicals by photo-induced electron transfer and fragmentation of the radical cation

A photoreactive G-quadruplex ligand triggered by green light.

A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging.

An Aggregating Amphiphilic Squaraine: A Light-up Probe That Discriminates Parallel G-Quadruplexes

An experimental and theoretical investigation of loperamide hydrochloride-glutaric acid cocrystals

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.

Assessment of gene promoter G‑quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells

Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking

Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies

Cationic Pentaheteroaryls as Selective G-Quadruplex Ligands by Solvent-Free Microwave-Assisted Synthesis

Characterization of Methylenepropenylidenecyclohexadiene Derivatives and Their Competing 1,6-Electrocyclic Reaction and 1,7-Hydrogen Shift at Room Temperature

Concerted vs stepwise mechanism in 1,3-dipolar cycloaddition of nitrone to ethene, cyclobutadiene, and benzocyclobutadiene. A computational study

Conjugation, Substituent, and Solvent Effects on the Photogeneration of Quinone Methides.

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide

Dyads of G-Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration

Epoxidation of acyclic chiral allylic alcohols with peroxy acids: spiro or planar butterfly transition structures? A computational DFT answer

Facial selectivity in epoxidation of 2-cyclohexen-1-ol with peroxy acids. A computational DFT study

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

G-quadruplex fluorescence sensing by core-extended naphthalene diimides

Homolytic vs heterolytic paths in the photochemistry of haloanilines

Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.

Hydrosoluble and solvatochromic naphthalene diimides with NIR absorption

Mechanochemical synthesis of bumetanide-4-aminobenzoic acid molecular cocrystals: a facile and green approach to drug optimization

Modeling H-bonding and solvent effects in the alkylation of pyrimidine bases by a prototype quinone methide: a DFT study.

Modeling substituent and conformational effects on the reactivity of antitumor agents containing a cyclopropylcyclohexadienone subunit

Modeling the photochemistry of the reference phototoxic drug lomefloxacin by steady-state and time-resolved experiments, and DFT and post-HF calculations

More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand

Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells

Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

Novel naphthalene diimides as activatable precursors of bisalkylating agents, by reduction and base catalysis.

Novel pathways for oxygen insertion into unactivated C-H bonds by dioxiranes. Transition structures for stepwise routes via radical pairs and comparison with the concerted pathway.

Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding

Photoarylation of alkenes and heteroaromatics by dibromo-BINOLs in aqueous solution.

Photoarylation/alkylation of bromonaphthols

Photochemical Synthesis of 4-Oxobutanal Acetals and of 2-Hydroxycyclobutanone Ketals

Photogenerated quinone methides as useful intermediates in the synthesis of chiral BINOL ligands.

Photoinduced SET for the functionalization of alkanes

Photoinduced, ionic Meerwein arylation of olefins.

Photosensitized oxidation of sulfides: discriminating between the singlet-oxygen mechanism and electron transfer involving superoxide anion or molecular oxygen

Planar transition structures in the epoxidation of alkenes. A DFT study on the reaction of peroxyformic acid with norbornene derivatives.

Protecting Group Free Synthesis of 6-Substituted Naphthols and Binols

Pyrrolo[3',2':6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity

Quinone methide generation via photoinduced electron transfer.

Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.

Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad.

Selective arylation, alkenylation, and cyclization of dibromonaphthols, using visible light, via carbene intermediates

Selectivity of purine alkylation by a quinone methide. Kinetic or thermodynamic control?

Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data

Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.

Substituted heterocyclic naphthalene diimides with unexpected acidity. Synthesis, properties, and reactivity.

Synthesis and antiproliferative mechanism of action of pyrrolo[3',2':6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers.

Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines

Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

Synthesis, spectroscopic characterization and chemical reactions of stable o-QM on solid phase

Targeting loop adenines in G-quadruplex by a selective oxirane.

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

The photochemical approach to the functionalization of open-chain and cyclic alkanes: 1. Single electron transfer oxidation

The photochemical approach to the functionalization of open-chain and cyclic alkanes: 2. Hydrogen abstraction

The photochemical reactions of 9,10-anthracenedicarbonitrile and 1,4-naphthalenedicarbonitrile in acetonitrile in the presence of bases

The role of SET in the deprotection of (thio)ketals under photosensitization by π-acceptors

Towards Building Blocks for Supramolecular Architectures Based on Azacryptates

Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands.

Water-soluble naphthalene diimides as singlet oxygen sensitizers.