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List of works by Frank B Furnari

A drosophila model for EGFR-Ras and PI3K-dependent human glioma

scientific article (publication date: February 2009)

A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma

scientific article (publication date: 2013)

A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression

scientific article (publication date: May 2002)

A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments

scientific article published on March 2013

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma

scientific article

Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.

scientific article published in July 1998

Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

scientific article published on 14 November 2011

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

scientific article published on September 2011

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.

scientific article published on October 2004

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

scientific article

Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.

scientific article

Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

scientific article published on 20 April 2020

Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

scientific article published on 18 January 2019

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor

scientific article

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

scientific article

Circular ecDNA promotes accessible chromatin and high oncogene expression

scientific article published on 20 November 2019

Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy.

scientific article

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

scientific article

Decoy for microRNAs

scientific article published in Nature

Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing

scientific article

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling

scientific article

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

scientific article

EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma

scientific article published on 12 May 2009

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

scientific article published on 5 December 2011

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180 ⬇️

scientific article published on 03 June 2013

EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration

scientific article published on 26 November 2020

Emerging insights into the molecular and cellular basis of glioblastoma

scientific article published in April 2012

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

scientific article

Epidermal growth factor receptor targeting and challenges in glioblastoma

scientific article published on 10 January 2016

Escape from targeted inhibition: the dark side of kinase inhibitor therapy

scientific article

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

scientific article published on 8 February 2017

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

scientific article

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients

scientific article published on 18 August 2009

Genetics and malignant progression of human brain tumours.

scientific article published on January 1995

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma

scientific article

Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.

scientific article

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain ⬇️

scientific article published on November 11, 1997

Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma

scientific article published on 12 December 2011

Heterogeneity maintenance in glioblastoma: a social network

scientific article

Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma

scientific article

Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma

scientific article

In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma ⬇️

scientific article published on August 4, 1998

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

scientific article published on 01 May 2019

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

scientific article published on 28 February 2019

Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin

scientific article published on 23 December 2016

Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy

scientific article published on 16 January 2020

Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals

scientific article published on 24 March 2014

Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins

scientific article published on 23 August 2019

Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

scientific article published on 28 January 2020

Loss of P16INK4 expression is frequent in high grade gliomas.

scientific article published in May 1995

MUTANT EGFR SUPPRESSION OF MICRORNA-9 INDUCES FOXP1 TO ENHANCE GLIOBLASTOMA TUMORIGENICITY.

scientific article published in July 2014

Malignant astrocytic glioma: genetics, biology, and paths to treatment

scientific article (publication date: November 2007)

Malignant glioma: genetics and biology of a grave matter.

scientific article published in June 2001

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

scientific article published on 10 February 2021

MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression

scientific article

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

scientific article

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting

scientific article published on September 2006

Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas.

scientific article

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

scientific article published on 24 April 2019

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.

scientific article

Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells.

scientific article published on May 2001

Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter

scientific article

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

scientific article published on 11 July 2019

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

scientific article published on 26 April 2019

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

scientific article published in May 2015

PCAF modulates PTEN activity

scientific article

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

scientific article (publication date: April 2005)

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

scientific article published on 25 February 2013

PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.

scientific article

PTEN: a novel anti-oncogenic function independent of phosphatase activity

scientific article

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

scientific article published on 7 February 2012

Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth

scientific article published on 11 May 2010

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

scholarly article

RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism

scientific article published on March 1994

Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin

Regulation of the Epstein-Barr virus DNA polymerase gene.

scientific article published on May 1992

Replacement of the p16/CDKN2 gene suppresses human glioma cell growth

scientific article published on 01 March 1995

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

scientific article

SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes

scientific article

SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability

scientific article published on 10 September 2020

Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme.

scientific article published on 4 November 2016

Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity

scientific article published on 16 January 2014

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

scientific article

Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.

scientific article

Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance.

scientific article

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy

scientific article

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)

scientific article published on 15 March 2016

The Efficacy of Epidermal Growth Factor Receptor-Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

scientific article published on 01 March 2007

The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

article

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

scientific article published on 30 October 2003

The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.

scientific article

Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks

scientific article published on December 2013

Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations

scientific article

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.

scientific article published in September 2005

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

scientific article

Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

scientific article

Uncovering therapeutic targets for glioblastoma: a systems biology approach

scientific article published on 20 August 2007

When less is more: Gaining power through gene rearrangement of amplified

article

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